Gene description for PVRL1
Gene name poliovirus receptor-related 1 (herpesvirus entry mediator C)
Gene symbol PVRL1
Other names/aliases CD111
CLPED1
ED4
HIgR
HV1S
HVEC
OFC7
PRR
PRR1
PVRR
PVRR1
SK-12
nectin-1
Species Homo sapiens
 Database cross references - PVRL1
ExoCarta ExoCarta_5818
Vesiclepedia VP_5818
Entrez Gene 5818
HGNC 9706
MIM 600644
UniProt Q15223  
 PVRL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PVRL1
Molecular Function
    coreceptor activity GO:0015026 TAS
    virus receptor activity GO:0001618 IEA
    virion binding GO:0046790 IEA
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IEA
    protein homodimerization activity GO:0042803 ISS
    cell adhesion molecule binding GO:0050839 IPI
    carbohydrate binding GO:0030246 IEA
Biological Process
    cell junction assembly GO:0034329 TAS
    axon guidance GO:0007411 IEA
    viral entry into host cell GO:0046718 NAS
    single organismal cell-cell adhesion GO:0016337 NAS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    regulation of synapse assembly GO:0051963 IEA
    desmosome organization GO:0002934 IEA
    cell adhesion GO:0007155 NAS
    adherens junction organization GO:0034332 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 ISS
    enamel mineralization GO:0070166 IEA
    signal transduction GO:0007165 TAS
    lens morphogenesis in camera-type eye GO:0002089 IEA
    immune response GO:0006955 NAS
    retina development in camera-type eye GO:0060041 IEA
    cell-cell junction organization GO:0045216 TAS
    iron ion transport GO:0006826 IEA
Subcellular Localization
    growth cone membrane GO:0032584 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
    catenin complex GO:0016342 IEA
    membrane GO:0016020 TAS
    cell-cell adherens junction GO:0005913 IDA
    integral component of membrane GO:0016021 NAS
    axon GO:0030424 IEA
    adherens junction GO:0005912 NAS
    plasma membrane GO:0005886 TAS
    presynaptic membrane GO:0042734 IEA
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified PVRL1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PVRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MLLT4 4301
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PVRL1 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome
Nectin/Necl trans heterodimerization TAS Reactome





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