Gene description for FGFR3
Gene name	fibroblast growth factor receptor 3
Gene symbol	FGFR3
Other names/aliases	ACH CD333 CEK2 HSFGFR3EX JTK4
Species	Homo sapiens
Database cross references - FGFR3
ExoCarta	ExoCarta_2261
Vesiclepedia	VP_2261
Entrez Gene	2261
HGNC	3690
MIM	134934
UniProt	P22607
FGFR3 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Neuroblastoma cells	25944692
Squamous carcinoma cells	20124223
Urine	25452312

Gene ontology annotations for FGFR3

Molecular Function     ATP binding GO:0005524 IEA     fibroblast growth factor-activated receptor activity GO:0005007 IMP     protein tyrosine kinase activity GO:0004713 IDA     fibroblast growth factor binding GO:0017134 IPI     protein binding GO:0005515 IPI Biological Process     protein autophosphorylation GO:0046777 IDA     positive regulation of protein ubiquitination GO:0031398 IEA     endochondral bone growth GO:0003416 TAS     alveolar secondary septum development GO:0061144 IEA     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 TAS     positive regulation of endothelial cell proliferation GO:0001938 IEA     substantia nigra development GO:0021762 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     negative regulation of developmental growth GO:0048640 ISS     negative regulation of astrocyte differentiation GO:0048712 IEA     positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     bone mineralization GO:0030282 ISS     epithelial cell fate commitment GO:0072148 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     bone morphogenesis GO:0060349 TAS     somatic stem cell maintenance GO:0035019 IEA     morphogenesis of an epithelium GO:0002009 IEA     negative regulation of epithelial cell proliferation GO:0050680 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     central nervous system myelination GO:0022010 IEA     positive regulation of MAPK cascade GO:0043410 IMP     chondrocyte proliferation GO:0035988 TAS     positive regulation of cell differentiation GO:0045597 IEA     MAPK cascade GO:0000165 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 IEA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IMP     forebrain development GO:0030900 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     fibroblast growth factor receptor apoptotic signaling pathway GO:1902178 IMP     negative regulation of mitotic nuclear division GO:0045839 IEA     endochondral ossification GO:0001958 TAS     digestive tract morphogenesis GO:0048546 IEA     bone maturation GO:0070977 ISS     axonogenesis involved in innervation GO:0060385 IEA     positive regulation of phospholipase activity GO:0010518 IMP     lens morphogenesis in camera-type eye GO:0002089 IEA     innate immune response GO:0045087 TAS     chondrocyte differentiation GO:0002062 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     positive regulation of cell proliferation GO:0008284 IMP     cochlea development GO:0090102 IEA     negative regulation of smoothened signaling pathway GO:0045879 IEA     skeletal system development GO:0001501 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     lens fiber cell development GO:0070307 IEA     positive regulation of neuron apoptotic process GO:0043525 IEA     insulin receptor signaling pathway GO:0008286 TAS     positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IMP     response to axon injury GO:0048678 IEA     inner ear receptor cell differentiation GO:0060113 IEA     cell-cell signaling GO:0007267 IEA     JAK-STAT cascade GO:0007259 TAS Subcellular Localization     integral component of plasma membrane GO:0005887 IDA     lysosome GO:0005764 IEA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 TAS     nucleus GO:0005634 IEA     perinuclear region of cytoplasm GO:0048471 IEA     transport vesicle GO:0030133 IDA     cell surface GO:0009986 IEA     extracellular region GO:0005576 IEA     cytoplasmic side of plasma membrane GO:0009898 IEA     endoplasmic reticulum GO:0005783 IEA     focal adhesion GO:0005925 TAS