Gene description for TMEM231
Gene name transmembrane protein 231
Gene symbol TMEM231
Other names/aliases ALYE870
JBTS20
MKS11
PRO1886
Species Homo sapiens
 Database cross references - TMEM231
ExoCarta ExoCarta_79583
Vesiclepedia VP_79583
Entrez Gene 79583
HGNC 37234
MIM 614949
UniProt Q9H6L2  
 TMEM231 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM231
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    in utero embryonic development GO:0001701 IEA
    vasculature development GO:0001944 IEA
    smoothened signaling pathway GO:0007224 ISS
    regulation of protein localization GO:0032880 IBA
    embryonic digit morphogenesis GO:0042733 IEA
    camera-type eye development GO:0043010 IEA
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 ISS
    neuroepithelial cell differentiation GO:0060563 IEA
Subcellular Localization
    ciliary transition zone GO:0035869 IBA
    ciliary transition zone GO:0035869 ISS
    MKS complex GO:0036038 ISS
    ciliary membrane GO:0060170 IBA
    ciliary membrane GO:0060170 ISS
 Experiment description of studies that identified TMEM231 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM231
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ATP1A3 478
Affinity Capture-MS Homo sapiens
3 STARD3NL 83930
Affinity Capture-MS Homo sapiens
4 SPPL3  
Affinity Capture-MS Homo sapiens
5 SPPL2B 56928
Affinity Capture-MS Homo sapiens
6 LRP10 26020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SEC63 11231
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
8 DNAJB14  
Proximity Label-MS Homo sapiens
9 POSTN 10631
Affinity Capture-MS Homo sapiens
10 LAPTM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PTPRF 5792
Affinity Capture-MS Homo sapiens
12 DNAJC11 55735
Proximity Label-MS Homo sapiens
13 NHLRC3 387921
Affinity Capture-MS Homo sapiens
14 B9D1 27077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MFAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TMEM218  
Affinity Capture-MS Homo sapiens
17 DNAJC19 131118
Proximity Label-MS Homo sapiens
18 CC2D2A  
Affinity Capture-MS Homo sapiens
19 TCTN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MKS1 54903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DAD1 1603
Affinity Capture-MS Homo sapiens
22 NDFIP2 54602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NOTCH2NL 388677
Two-hybrid Homo sapiens
24 LSR 51599
Affinity Capture-MS Homo sapiens
25 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
26 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DNAJB2 3300
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
28 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SYNE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 DNAJA3 9093
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
31 NCEH1 57552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 UGCG 7357
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 FBXO6 26270
Affinity Capture-MS Homo sapiens
34 THEM6  
Affinity Capture-MS Homo sapiens
35 DNAJB3 414061
Affinity Capture-MS Homo sapiens
36 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 STARD3 10948
Affinity Capture-MS Homo sapiens
38 NDFIP1 80762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 FGFR3 2261
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 EPHA7 2045
Affinity Capture-MS Homo sapiens
41 VAMP7 6845
Affinity Capture-MS Homo sapiens
42 EPHA3 2042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PLEKHB2 55041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PRKACA 5566
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
45 CHRNB2  
Affinity Capture-MS Homo sapiens
46 PTPRS 5802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 FBXO2 26232
Affinity Capture-MS Homo sapiens
48 DDR1 780
Affinity Capture-MS Homo sapiens
49 DNAJB4 11080
Affinity Capture-MS Homo sapiens
50 B9D2 80776
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RAB9A 9367
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CHRNA3 1136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PTCHD3  
Affinity Capture-MS Homo sapiens
55 KRT40  
Two-hybrid Homo sapiens
56 MAGT1 84061
Affinity Capture-MS Homo sapiens
57 DNAJC3 5611
Affinity Capture-MS Homo sapiens
58 PREB 10113
Affinity Capture-MS Homo sapiens
59 PI4K2A 55361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 WFS1 7466
Affinity Capture-MS Homo sapiens
61 GPR37  
Two-hybrid Homo sapiens
62 UPK1A 11045
Affinity Capture-MS Homo sapiens
63 RNF130  
Affinity Capture-MS Homo sapiens
64 ATP2C1 27032
Affinity Capture-MS Homo sapiens
65 ADIPOR1 51094
Affinity Capture-MS Homo sapiens
66 KRT31 3881
Two-hybrid Homo sapiens
67 BTNL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 OSMR 9180
Affinity Capture-MS Homo sapiens
69 DNAJB11 51726
Affinity Capture-MS Homo sapiens
70 CRNN 49860
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM231 is involved
No pathways found





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