Gene description for ADIPOR1
Gene name adiponectin receptor 1
Gene symbol ADIPOR1
Other names/aliases ACDCR1
CGI-45
CGI45
PAQR1
TESBP1A
Species Homo sapiens
 Database cross references - ADIPOR1
ExoCarta ExoCarta_51094
Vesiclepedia VP_51094
Entrez Gene 51094
HGNC 24040
MIM 607945
UniProt Q96A54  
 ADIPOR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ADIPOR1
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    signaling receptor activity GO:0038023 IBA
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
    adiponectin binding GO:0055100 IDA
    adipokinetic hormone receptor activity GO:0097003 IDA
Biological Process
    hormone-mediated signaling pathway GO:0009755 IDA
    negative regulation of epithelial cell migration GO:0010633 IMP
    negative regulation of epithelial to mesenchymal transition GO:0010719 IMP
    regulation of glucose metabolic process GO:0010906 ISS
    regulation of lipid metabolic process GO:0019216 ISS
    fatty acid oxidation GO:0019395 IDA
    negative regulation of cell growth GO:0030308 IEA
    leptin-mediated signaling pathway GO:0033210 IEA
    adiponectin-activated signaling pathway GO:0033211 IBA
    adiponectin-activated signaling pathway GO:0033211 IDA
    glucose homeostasis GO:0042593 ISS
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IMP
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IEA
    positive regulation of insulin receptor signaling pathway GO:0046628 IEA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified ADIPOR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADIPOR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 TACR3  
Affinity Capture-MS Homo sapiens
3 MAGEA8  
Affinity Capture-MS Homo sapiens
4 DPH3  
Two-hybrid Homo sapiens
5 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SLC22A16 85413
Affinity Capture-MS Homo sapiens
7 FAM45A 404636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC18A1  
Affinity Capture-MS Homo sapiens
10 TSPAN15 23555
Affinity Capture-MS Homo sapiens
11 APPL1 26060
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
12 MARCH1  
Affinity Capture-MS Homo sapiens
13 NAA20  
Two-hybrid Homo sapiens
14 KCNK18  
Affinity Capture-MS Homo sapiens
15 BSCL2  
Affinity Capture-MS Homo sapiens
16 GPR12  
Affinity Capture-MS Homo sapiens
17 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 AQP3  
Affinity Capture-MS Homo sapiens
20 OPRL1 4987
Affinity Capture-MS Homo sapiens
21 TSPAN3 10099
Affinity Capture-MS Homo sapiens
22 MOV10 4343
Affinity Capture-RNA Homo sapiens
23 MYC  
Affinity Capture-MS Homo sapiens
24 C16orf58 64755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NFKBIL1  
Two-hybrid Homo sapiens
27 GINM1 116254
Affinity Capture-MS Homo sapiens
28 TMEM231 79583
Affinity Capture-MS Homo sapiens
29 KRAS 3845
Proximity Label-MS Homo sapiens
30 WFS1 7466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GNAI2 2771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MRAP2  
Affinity Capture-MS Homo sapiens
33 RAB2A 5862
Proximity Label-MS Homo sapiens
34 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 TSPAN10 83882
Affinity Capture-MS Homo sapiens
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