Gene description for OPRL1
Gene name opiate receptor-like 1
Gene symbol OPRL1
Other names/aliases KOR-3
Species Homo sapiens
 Database cross references - OPRL1
ExoCarta ExoCarta_4987
Entrez Gene 4987
HGNC 8155
MIM 602548
UniProt P41146  
 OPRL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for OPRL1
Molecular Function
    neuropeptide binding GO:0042923 IBA
    nociceptin receptor activity GO:0001626 IDA
    G-protein coupled receptor activity GO:0004930 IMP
    protein binding GO:0005515 IPI
Biological Process
    sensory perception of pain GO:0019233 ISS
    synaptic transmission GO:0007268 IBA
    neuropeptide signaling pathway GO:0007218 IBA
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IMP
    sensory perception GO:0007600 TAS
    opioid receptor signaling pathway GO:0038003 IEA
    behavior GO:0007610 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IGI
Subcellular Localization
    neuron projection GO:0043005 IBA
    integral component of plasma membrane GO:0005887 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    cytosol GO:0005829 IGI
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified OPRL1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for OPRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PNOC  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 GNA14 9630
Affinity Capture-MS Homo sapiens
3 RGS19  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which OPRL1 is involved
G alpha (i) signalling events TAS Reactome
Peptide ligand-binding receptors TAS Reactome

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