Gene description for OPRL1
Gene name opiate receptor-like 1
Gene symbol OPRL1
Other names/aliases KOR-3
NOCIR
OOR
ORL1
Species Homo sapiens
 Database cross references - OPRL1
ExoCarta ExoCarta_4987
Vesiclepedia VP_4987
Entrez Gene 4987
HGNC 8155
MIM 602548
UniProt P41146  
 OPRL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for OPRL1
Molecular Function
    nociceptin receptor activity GO:0001626 IBA
    nociceptin receptor activity GO:0001626 IDA
    G protein-coupled receptor activity GO:0004930 IMP
    G protein-coupled receptor activity GO:0004930 IPI
    protein binding GO:0005515 IPI
    neuropeptide binding GO:0042923 IBA
Biological Process
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IMP
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IPI
    neuropeptide signaling pathway GO:0007218 IBA
    sensory perception GO:0007600 TAS
    sensory perception of pain GO:0019233 IBA
    sensory perception of pain GO:0019233 ISS
    calcium-mediated signaling GO:0019722 IDA
    response to estradiol GO:0032355 IEA
    positive regulation of urine volume GO:0035810 IEA
    G protein-coupled opioid receptor signaling pathway GO:0038003 IEA
    eating behavior GO:0042755 IEA
    negative regulation of cAMP-mediated signaling GO:0043951 IEA
    estrous cycle GO:0044849 IEA
    negative regulation of blood pressure GO:0045776 IEA
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 IEA
    regulation of locomotor rhythm GO:1904059 IEA
    conditioned place preference GO:1990708 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cytoplasmic vesicle GO:0031410 IEA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified OPRL1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for OPRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAPPC2 6399
Affinity Capture-MS Homo sapiens
2 TMEM164  
Affinity Capture-MS Homo sapiens
3 MTFP1  
Affinity Capture-MS Homo sapiens
4 ENPP4 22875
Affinity Capture-MS Homo sapiens
5 SLC31A2  
Two-hybrid Homo sapiens
6 MTX1 4580
Affinity Capture-MS Homo sapiens
7 TUBB8 347688
Affinity Capture-MS Homo sapiens
8 NDUFB5 4711
Affinity Capture-MS Homo sapiens
9 ATP12A 479
Affinity Capture-MS Homo sapiens
10 TMEM186  
Affinity Capture-MS Homo sapiens
11 MFSD8 256471
Affinity Capture-MS Homo sapiens
12 ST3GAL2 6483
Affinity Capture-MS Homo sapiens
13 INTS1 26173
Affinity Capture-MS Homo sapiens
14 ATP5L 10632
Affinity Capture-MS Homo sapiens
15 DEGS1  
Affinity Capture-MS Homo sapiens
16 PTDSS2 81490
Affinity Capture-MS Homo sapiens
17 SLC25A14  
Affinity Capture-MS Homo sapiens
18 LPGAT1 9926
Affinity Capture-MS Homo sapiens
19 RINT1 60561
Affinity Capture-MS Homo sapiens
20 NAV1 89796
Affinity Capture-MS Homo sapiens
21 METAP2 10988
Affinity Capture-MS Homo sapiens
22 TM9SF1 10548
Affinity Capture-MS Homo sapiens
23 ATP8  
Affinity Capture-MS Homo sapiens
24 ATP5O 539
Affinity Capture-MS Homo sapiens
25 FADS1 3992
Affinity Capture-MS Homo sapiens
26 ORMDL2 29095
Affinity Capture-MS Homo sapiens
27 WDFY3 23001
Affinity Capture-MS Homo sapiens
28 BTAF1 9044
Affinity Capture-MS Homo sapiens
29 PNOC  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
30 ATP5H 10476
Affinity Capture-MS Homo sapiens
31 RAB39B 116442
Affinity Capture-MS Homo sapiens
32 POTEKP 440915
Affinity Capture-MS Homo sapiens
33 PDS5B 23047
Affinity Capture-MS Homo sapiens
34 ATP1A3 478
Affinity Capture-MS Homo sapiens
35 GPRASP1  
Reconstituted Complex Homo sapiens
36 ATP5A1 498
Affinity Capture-MS Homo sapiens
37 TSPAN3 10099
Affinity Capture-MS Homo sapiens
38 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
39 CERS2 29956
Affinity Capture-MS Homo sapiens
40 PDXDC1 23042
Affinity Capture-MS Homo sapiens
41 CHPT1  
Affinity Capture-MS Homo sapiens
42 ACAD10  
Affinity Capture-MS Homo sapiens
43 SLC9A1 6548
Affinity Capture-MS Homo sapiens
44 ACTB 60
Affinity Capture-MS Homo sapiens
45 TUBA1C 84790
Affinity Capture-MS Homo sapiens
46 TMEM56  
Affinity Capture-MS Homo sapiens
47 FAM127A  
Affinity Capture-MS Homo sapiens
48 DNAJC30  
Two-hybrid Homo sapiens
49 ACSL4 2182
Affinity Capture-MS Homo sapiens
50 SLC33A1 9197
Affinity Capture-MS Homo sapiens
51 MFSD12  
Affinity Capture-MS Homo sapiens
52 SPPL3  
Affinity Capture-MS Homo sapiens
53 P2RX4 5025
Affinity Capture-MS Homo sapiens
54 SLC25A24 29957
Affinity Capture-MS Homo sapiens
55 C4orf32  
Affinity Capture-MS Homo sapiens
56 CLN3 1201
Affinity Capture-MS Homo sapiens
57 PTEN 5728
Synthetic Growth Defect Homo sapiens
58 SLC20A2 6575
Affinity Capture-MS Homo sapiens
59 SLC35F2 54733
Affinity Capture-MS Homo sapiens
60 ACTBL2 345651
Affinity Capture-MS Homo sapiens
61 ATP5F1 515
Affinity Capture-MS Homo sapiens
62 ABCC10  
Affinity Capture-MS Homo sapiens
63 OMA1  
Affinity Capture-MS Homo sapiens
64 TMEM246 84302
Affinity Capture-MS Homo sapiens
65 LPCAT3 10162
Affinity Capture-MS Homo sapiens
66 PLLP  
Two-hybrid Homo sapiens
67 TM9SF3 56889
Affinity Capture-MS Homo sapiens
68 SLC35B2 347734
Affinity Capture-MS Homo sapiens
69 TUBA4A 7277
Affinity Capture-MS Homo sapiens
70 NDUFB3 4709
Affinity Capture-MS Homo sapiens
71 CERS6  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
72 DYM  
Affinity Capture-MS Homo sapiens
73 THADA 63892
Affinity Capture-MS Homo sapiens
74 METTL15  
Affinity Capture-MS Homo sapiens
75 SLC25A30 253512
Affinity Capture-MS Homo sapiens
76 ADCK1  
Affinity Capture-MS Homo sapiens
77 ATP2B3 492
Affinity Capture-MS Homo sapiens
78 LMBRD2 92255
Affinity Capture-MS Homo sapiens
79 SLC19A2 10560
Affinity Capture-MS Homo sapiens
80 PEX16 9409
Affinity Capture-MS Homo sapiens
81 ATP2B4 493
Affinity Capture-MS Homo sapiens
82 KNTC1 9735
Affinity Capture-MS Homo sapiens
83 ATL2 64225
Affinity Capture-MS Homo sapiens
84 ABCC4 10257
Affinity Capture-MS Homo sapiens
85 TTK 7272
Affinity Capture-MS Homo sapiens
86 STARD3 10948
Affinity Capture-MS Homo sapiens
87 MGAT4B 11282
Affinity Capture-MS Homo sapiens
88 HACD2 201562
Affinity Capture-MS Homo sapiens
89 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
90 TMEM126B 55863
Affinity Capture-MS Homo sapiens
91 ATP5B 506
Affinity Capture-MS Homo sapiens
92 ATP2B2 491
Affinity Capture-MS Homo sapiens
93 ATP5C1 509
Affinity Capture-MS Homo sapiens
94 ABHD17B 51104
Affinity Capture-MS Homo sapiens
95 ADIPOR1 51094
Affinity Capture-MS Homo sapiens
96 HLA-C 3107
Two-hybrid Homo sapiens
View the network image/svg+xml



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