Gene description for ATP5C1
Gene name ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Gene symbol ATP5C1
Other names/aliases ATP5C
Species Homo sapiens
 Database cross references - ATP5C1
ExoCarta ExoCarta_509
Entrez Gene 509
HGNC 833
MIM 108729
UniProt P36542  
 ATP5C1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ATP5C1
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    ATPase activity GO:0016887 NAS
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IEA
    transmembrane transporter activity GO:0022857 IC
    proton-transporting ATP synthase activity, rotational mechanism GO:0046933 IEA
Biological Process
    mitochondrial ATP synthesis coupled proton transport GO:0042776 TAS
    cellular metabolic process GO:0044237 TAS
    ATP biosynthetic process GO:0006754 NAS
    small molecule metabolic process GO:0044281 TAS
    oxidative phosphorylation GO:0006119 NAS
    respiratory electron transport chain GO:0022904 TAS
Subcellular Localization
    mitochondrial proton-transporting ATP synthase complex GO:0005753 IDA
    mitochondrial matrix GO:0005759 TAS
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 IDA
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrion GO:0005739 NAS
    mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) GO:0000275 NAS
 Experiment description of studies that identified ATP5C1 in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP5C1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CA12 771
Two-hybrid Homo sapiens
2 MPP1 4354
Two-hybrid Homo sapiens
3 DPP3 10072
Two-hybrid Homo sapiens
4 POLA2  
Two-hybrid Homo sapiens
5 PTN  
Two-hybrid Homo sapiens
6 CCT7 10574
Two-hybrid Homo sapiens
7 NDUFB3  
Two-hybrid Homo sapiens
8 ELOF1  
Two-hybrid Homo sapiens
9 NGEF  
Two-hybrid Homo sapiens
10 PJA1  
Two-hybrid Homo sapiens
11 CHMP2B 25978
Two-hybrid Homo sapiens
12 ITIH2 3698
Two-hybrid Homo sapiens
13 PCQAP  
Two-hybrid Homo sapiens
14 EGFR 1956
Two-hybrid Homo sapiens
15 CCND3  
Two-hybrid Homo sapiens
16 PNO1 56902
Two-hybrid Homo sapiens
17 GDPD2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ATP5C1 is involved
Formation of ATP by chemiosmotic coupling TAS Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here