Gene description for TMEM87A
Gene name transmembrane protein 87A
Gene symbol TMEM87A
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM87A
ExoCarta ExoCarta_25963
Vesiclepedia VP_25963
Entrez Gene 25963
HGNC 24522
UniProt Q8NBN3  
 TMEM87A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TMEM87A
Molecular Function
    mechanosensitive potassium channel activity GO:0098782 IDA
Biological Process
    retrograde transport, endosome to Golgi GO:0042147 IBA
    retrograde transport, endosome to Golgi GO:0042147 IGI
    detection of mechanical stimulus involved in sensory perception of touch GO:0050976 IMP
    cellular response to mechanical stimulus GO:0071260 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    ruffle GO:0001726 IDA
    ruffle GO:0001726 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IEA
    Golgi cisterna membrane GO:0032580 IBA
    Golgi cisterna membrane GO:0032580 IDA
 Experiment description of studies that identified TMEM87A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMEM87A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GJD3  
Proximity Label-MS Homo sapiens
2 OCLN 100506658
Proximity Label-MS Homo sapiens
3 TSPAN15 23555
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 LAMP3  
Proximity Label-MS Homo sapiens
6 SYNGR1 9145
Affinity Capture-MS Homo sapiens
7 SLC39A4 55630
Affinity Capture-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 TOR1B 27348
Affinity Capture-MS Homo sapiens
10 ACKR2  
Affinity Capture-MS Homo sapiens
11 TMEM184A  
Affinity Capture-MS Homo sapiens
12 LAMP2 3920
Proximity Label-MS Homo sapiens
13 SLC7A14  
Affinity Capture-MS Homo sapiens
14 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 POMGNT2  
Affinity Capture-MS Homo sapiens
16 FGFR3 2261
Affinity Capture-MS Homo sapiens
17 ADAM21  
Affinity Capture-MS Homo sapiens
18 PIGN 23556
Affinity Capture-MS Homo sapiens
19 B3GAT1  
Proximity Label-MS Homo sapiens
20 SCARA3  
Affinity Capture-MS Homo sapiens
21 PC 5091
Affinity Capture-MS Homo sapiens
22 LRP5 4041
Affinity Capture-MS Homo sapiens
23 P2RY1  
Affinity Capture-MS Homo sapiens
24 TRMT44  
Affinity Capture-MS Homo sapiens
25 NAGA 4668
Affinity Capture-MS Homo sapiens
26 RAB3B 5865
Proximity Label-MS Homo sapiens
27 ERAP1 51752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FGFR4 2264
Affinity Capture-MS Homo sapiens
29 OAF 220323
Affinity Capture-MS Homo sapiens
30 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
31 GPBAR1  
Affinity Capture-MS Homo sapiens
32 SRP14 6727
Affinity Capture-MS Homo sapiens
33 ATP2A3 489
Affinity Capture-MS Homo sapiens
34 BTNL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KRAS 3845
Proximity Label-MS Homo sapiens
36 SUN2 25777
Affinity Capture-MS Homo sapiens
37 STX6 10228
Proximity Label-MS Homo sapiens
38 GUSB 2990
Affinity Capture-MS Homo sapiens
39 TOR3A 64222
Affinity Capture-MS Homo sapiens
40 KLK6 5653
Affinity Capture-MS Homo sapiens
41 IL17RA 23765
Affinity Capture-MS Homo sapiens
42 RAB35 11021
Proximity Label-MS Homo sapiens
43 USP7 7874
Affinity Capture-MS Homo sapiens
44 TLL2  
Affinity Capture-MS Homo sapiens
45 EBAG9 9166
Proximity Label-MS Homo sapiens
46 P3H4 10609
Affinity Capture-MS Homo sapiens
47 GPR17 2840
Affinity Capture-MS Homo sapiens
48 MARCKS 4082
Proximity Label-MS Homo sapiens
49 LAMTOR1 55004
Proximity Label-MS Homo sapiens
50 MICA 100507436
Affinity Capture-MS Homo sapiens
51 LMAN1 3998
Proximity Label-MS Homo sapiens
52 CHID1 66005
Affinity Capture-MS Homo sapiens
53 NUP155 9631
Proximity Label-MS Homo sapiens
54 KCNK1  
Affinity Capture-MS Homo sapiens
55 HTR3C  
Affinity Capture-MS Homo sapiens
56 NOMO1 23420
Affinity Capture-MS Homo sapiens
57 SEMA6B 10501
Affinity Capture-MS Homo sapiens
58 CXADR 1525
Proximity Label-MS Homo sapiens
59 CLSTN1 22883
Affinity Capture-MS Homo sapiens
60 RAB4A 5867
Proximity Label-MS Homo sapiens
61 MANBA 4126
Affinity Capture-MS Homo sapiens
62 CSPG4 1464
Affinity Capture-MS Homo sapiens
63 CDH1 999
Proximity Label-MS Homo sapiens
64 DIRAS3  
Proximity Label-MS Homo sapiens
65 GPR182  
Affinity Capture-MS Homo sapiens
66 MIA3 375056
Affinity Capture-MS Homo sapiens
67 JAG2  
Affinity Capture-MS Homo sapiens
68 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 RPN1 6184
Proximity Label-MS Homo sapiens
70 PCSK9 255738
Affinity Capture-MS Homo sapiens
71 TMEM63A 9725
Affinity Capture-MS Homo sapiens
72 UPK1A 11045
Affinity Capture-MS Homo sapiens
73 AGPS 8540
Co-fractionation Homo sapiens
74 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ELOVL5 60481
Proximity Label-MS Homo sapiens
76 METRNL 284207
Affinity Capture-MS Homo sapiens
77 CERCAM 51148
Affinity Capture-MS Homo sapiens
78 UPK2 7379
Affinity Capture-MS Homo sapiens
79 SNX1 6642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 APLNR  
Affinity Capture-MS Homo sapiens
81 TTYH1  
Affinity Capture-MS Homo sapiens
82 CANX 821
Affinity Capture-MS Homo sapiens
83 MAN2B2 23324
Affinity Capture-MS Homo sapiens
84 AGPAT1 10554
Affinity Capture-MS Homo sapiens
85 RAB5A 5868
Proximity Label-MS Homo sapiens
86 DUOXA2  
Affinity Capture-MS Homo sapiens
87 LAMB2 3913
Affinity Capture-MS Homo sapiens
88 NPTN 27020
Affinity Capture-MS Homo sapiens
89 LAMP1 3916
Proximity Label-MS Homo sapiens
90 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
91 CMKLR1 1240
Affinity Capture-MS Homo sapiens
92 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 P2RY2 5029
Affinity Capture-MS Homo sapiens
94 HSD3B7 80270
Proximity Label-MS Homo sapiens
95 LOXL2 4017
Affinity Capture-MS Homo sapiens
96 NAGLU 4669
Affinity Capture-MS Homo sapiens
97 ARF6 382
Proximity Label-MS Homo sapiens
98 ENTPD7  
Affinity Capture-MS Homo sapiens
99 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 SYP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 VWDE  
Affinity Capture-MS Homo sapiens
102 TSPAN8 7103
Affinity Capture-MS Homo sapiens
103 CHRNA5  
Affinity Capture-MS Homo sapiens
104 TMEM132A 54972
Affinity Capture-MS Homo sapiens
105 LAMA3 3909
Affinity Capture-MS Homo sapiens
106 ADORA2B  
Affinity Capture-MS Homo sapiens
107 CRTAP 10491
Affinity Capture-MS Homo sapiens
108 RAB9A 9367
Proximity Label-MS Homo sapiens
109 GOLGA1  
Proximity Label-MS Homo sapiens
110 TIMP1 7076
Affinity Capture-MS Homo sapiens
111 ENTPD2 954
Affinity Capture-MS Homo sapiens
112 RHOB 388
Proximity Label-MS Homo sapiens
113 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
114 ATP5C1 509
Affinity Capture-MS Homo sapiens
115 SLC22A4 6583
Affinity Capture-MS Homo sapiens
116 SLC9A6 10479
Affinity Capture-MS Homo sapiens
117 TMEM131  
Affinity Capture-MS Homo sapiens
118 CLPP 8192
Proximity Label-MS Homo sapiens
119 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 NAAA  
Affinity Capture-MS Homo sapiens
121 TTC17 55761
Affinity Capture-MS Homo sapiens
122 EDNRA 1909
Affinity Capture-MS Homo sapiens
123 GLRA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 PCSK6 5046
Affinity Capture-MS Homo sapiens
125 ATP5J 522
Affinity Capture-MS Homo sapiens
126 POTEF 728378
Affinity Capture-MS Homo sapiens
127 PLXNA1 5361
Affinity Capture-MS Homo sapiens
128 VWA9  
Affinity Capture-MS Homo sapiens
129 CELSR1 9620
Affinity Capture-MS Homo sapiens
130 TSPAN17 26262
Affinity Capture-MS Homo sapiens
131 OXSR1 9943
Affinity Capture-MS Homo sapiens
132 B4GAT1 11041
Affinity Capture-MS Homo sapiens
133 UBR3  
Affinity Capture-MS Homo sapiens
134 KCNK4  
Affinity Capture-MS Homo sapiens
135 EDEM3 80267
Affinity Capture-MS Homo sapiens
136 EDEM2  
Affinity Capture-MS Homo sapiens
137 GAS6 2621
Affinity Capture-MS Homo sapiens
138 SFTPC  
Affinity Capture-MS Homo sapiens
139 ATP6V0C 527
Affinity Capture-MS Homo sapiens
140 GALNT18  
Affinity Capture-MS Homo sapiens
141 RAB2A 5862
Proximity Label-MS Homo sapiens
142 C3orf38 285237
Affinity Capture-MS Homo sapiens
143 RAB7A 7879
Proximity Label-MS Homo sapiens
144 RAB11A 8766
Proximity Label-MS Homo sapiens
145 BMP8A  
Affinity Capture-MS Homo sapiens
146 LAMB3 3914
Affinity Capture-MS Homo sapiens
147 KLHL22 84861
Affinity Capture-MS Homo sapiens
148 VIPR1  
Affinity Capture-MS Homo sapiens
149 RAB5C 5878
Proximity Label-MS Homo sapiens
150 ADGRE5 976
Affinity Capture-MS Homo sapiens
151 HTR1B  
Affinity Capture-MS Homo sapiens
152 CCR6  
Affinity Capture-MS Homo sapiens
153 ARSK  
Affinity Capture-MS Homo sapiens
154 OR1D4  
Affinity Capture-MS Homo sapiens
155 CAV1 857
Proximity Label-MS Homo sapiens
156 FPR2  
Affinity Capture-MS Homo sapiens
157 SPCS2 9789
Co-fractionation Homo sapiens
158 S1PR4  
Affinity Capture-MS Homo sapiens
159 CPE 1363
Affinity Capture-MS Homo sapiens
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