Gene description for AGPS
Gene name alkylglycerone phosphate synthase
Gene symbol AGPS
Other names/aliases ADAP-S
ADAS
ADHAPS
ADPS
ALDHPSY
Species Homo sapiens
 Database cross references - AGPS
ExoCarta ExoCarta_8540
Entrez Gene 8540
HGNC 327
MIM 603051
UniProt O00116  
 AGPS identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25519911    
Prostate cancer cells 25519911    
 Gene ontology annotations for AGPS
Molecular Function
    FAD binding GO:0071949 ISS
    UDP-N-acetylmuramate dehydrogenase activity GO:0008762 IEA
    protein binding GO:0005515 IPI
    alkylglycerone-phosphate synthase activity GO:0008609 IDA
Biological Process
    oxidation-reduction process GO:0055114 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular lipid metabolic process GO:0044255 TAS
    lipid biosynthetic process GO:0008610 IDA
    ether lipid biosynthetic process GO:0008611 TAS
Subcellular Localization
    nucleolus GO:0005730 IDA
    peroxisome GO:0005777 IDA
    peroxisomal matrix GO:0005782 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    membrane GO:0016020 IDA
    peroxisomal membrane GO:0005778 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified AGPS in exosomes
1
Experiment ID 248
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25519911    
Organism Homo sapiens
Experiment description The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
Authors Phuyal S, Skotland T, Hessvik NP, Simolin H, Overbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A.
Journal name J Biol Chem
Publication year 2015
Sample Prostate cancer cells
Sample name PC-3 - non-transfected
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Lipids
Methods used in the study Western blotting
2
Experiment ID 249
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25519911    
Organism Homo sapiens
Experiment description The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
Authors Phuyal S, Skotland T, Hessvik NP, Simolin H, Overbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A.
Journal name J Biol Chem
Publication year 2015
Sample Prostate cancer cells
Sample name PC-3 - transfected with alkylglycerone phosphate synthase siRNA
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Lipids
Methods used in the study Western blotting
 Protein-protein interactions for AGPS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNPAT  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which AGPS is involved
PathwayEvidenceSource
Plasmalogen biosynthesis TAS Reactome





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