Gene description for IDH3G
Gene name isocitrate dehydrogenase 3 (NAD+) gamma
Gene symbol IDH3G
Other names/aliases H-IDHG
Species Homo sapiens
 Database cross references - IDH3G
ExoCarta ExoCarta_3421
Vesiclepedia VP_3421
Entrez Gene 3421
HGNC 5386
MIM 300089
UniProt P51553  
 IDH3G identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IDH3G
Molecular Function
    magnesium ion binding GO:0000287 IDA
    isocitrate dehydrogenase (NAD+) activity GO:0004449 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    NAD binding GO:0051287 IEA
Biological Process
    carbohydrate metabolic process GO:0005975 NAS
    tricarboxylic acid cycle GO:0006099 IBA
    tricarboxylic acid cycle GO:0006099 IDA
    isocitrate metabolic process GO:0006102 IBA
    isocitrate metabolic process GO:0006102 ISS
Subcellular Localization
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISS
    mitochondrion GO:0005739 NAS
    mitochondrial matrix GO:0005759 TAS
    isocitrate dehydrogenase complex (NAD+) GO:0045242 IDA
    isocitrate dehydrogenase complex (NAD+) GO:0045242 IPI
 Experiment description of studies that identified IDH3G in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IDH3G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SBDS 51119
Co-fractionation Homo sapiens
2 AHSA1 10598
Co-fractionation Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MRPS7 51081
Affinity Capture-MS Homo sapiens
5 PQBP1  
Co-fractionation Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 ICE2  
Affinity Capture-MS Homo sapiens
8 IDH3B 3420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
Co-fractionation Homo sapiens
9 SUGP1  
Co-fractionation Homo sapiens
10 CIAO1 9391
Affinity Capture-MS Homo sapiens
11 ADRB2  
Affinity Capture-MS Homo sapiens
12 SCP2 6342
Co-fractionation Homo sapiens
13 EGFR 1956
Affinity Capture-MS Homo sapiens
14 FAHD1 81889
Affinity Capture-MS Homo sapiens
15 BPNT1 10380
Affinity Capture-MS Homo sapiens
16 PARK2  
Affinity Capture-MS Homo sapiens
17 KPNA2 3838
Co-fractionation Homo sapiens
18 HNRNPK 3190
Co-fractionation Homo sapiens
19 IDH3A 3419
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
20 OCIAD1 54940
Affinity Capture-MS Homo sapiens
21 APEX1 328
Affinity Capture-RNA Homo sapiens
22 RAB8A 4218
Co-fractionation Homo sapiens
23 IDH2 3418
Co-fractionation Homo sapiens
24 PPP1R12A 4659
Co-fractionation Homo sapiens
25 CDV3 55573
Co-fractionation Homo sapiens
26 MYC  
Affinity Capture-MS Homo sapiens
27 YARS2  
Affinity Capture-MS Homo sapiens
28 SPR 6697
Co-fractionation Homo sapiens
29 RPL35A 6165
Affinity Capture-MS Homo sapiens
30 ACO2 50
Co-fractionation Homo sapiens
31 FBXW7  
Affinity Capture-MS Homo sapiens
32 SERBP1 26135
Affinity Capture-MS Homo sapiens
33 PTH2R  
Affinity Capture-MS Homo sapiens
34 EDF1 8721
Co-fractionation Homo sapiens
35 C9orf72  
Affinity Capture-MS Homo sapiens
36 POU5F1  
Affinity Capture-MS Homo sapiens
37 TIMM44 10469
Co-fractionation Homo sapiens
38 HSPD1 3329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 AGPS 8540
Co-fractionation Homo sapiens
40 IDH1 3417
Co-fractionation Homo sapiens
41 MALSU1  
Affinity Capture-MS Homo sapiens
42 UQCRFS1P1  
Co-fractionation Homo sapiens
43 CUL4A 8451
Affinity Capture-MS Homo sapiens
44 EP300 2033
Affinity Capture-MS Homo sapiens
45 ZFYVE1 53349
Affinity Capture-MS Homo sapiens
46 BCOR  
Affinity Capture-MS Homo sapiens
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