Gene description for ACO2
Gene name aconitase 2, mitochondrial
Gene symbol ACO2
Other names/aliases ACONM
ICRD
OCA8
Species Homo sapiens
 Database cross references - ACO2
ExoCarta ExoCarta_50
Entrez Gene 50
HGNC 118
MIM 100850
UniProt Q99798  
 ACO2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for ACO2
Molecular Function
    iron ion binding GO:0005506 IDA
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
    3 iron, 4 sulfur cluster binding GO:0051538 IEA
    aconitate hydratase activity GO:0003994 IEA
Biological Process
    citrate metabolic process GO:0006101 IDA
    generation of precursor metabolites and energy GO:0006091 TAS
    tricarboxylic acid cycle GO:0006099 TAS
    small molecule metabolic process GO:0044281 TAS
    cellular metabolic process GO:0044237 TAS
    isocitrate metabolic process GO:0006102 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified ACO2 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACO2 is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) TAS Reactome
Mitochondrial protein import TAS Reactome





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