Gene description for SOD1
Gene name superoxide dismutase 1, soluble
Gene symbol SOD1
Other names/aliases ALS
ALS1
HEL-S-44
IPOA
SOD
hSod1
homodimer
Species Homo sapiens
 Database cross references - SOD1
ExoCarta ExoCarta_6647
Vesiclepedia VP_6647
Entrez Gene 6647
HGNC 11179
MIM 147450
UniProt P00441  
 SOD1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for SOD1
Molecular Function
    superoxide dismutase activity GO:0004784 IBA
    superoxide dismutase activity GO:0004784 IDA
    copper ion binding GO:0005507 IBA
    copper ion binding GO:0005507 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    protein phosphatase 2B binding GO:0030346 IDA
    small GTPase binding GO:0031267 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    protein-folding chaperone binding GO:0051087 IPI
Biological Process
    response to superoxide GO:0000303 IDA
    ovarian follicle development GO:0001541 ISS
    positive regulation of cytokine production GO:0001819 IDA
    placenta development GO:0001890 NAS
    retina homeostasis GO:0001895 ISS
    myeloid cell homeostasis GO:0002262 ISS
    glutathione metabolic process GO:0006749 ISS
    superoxide metabolic process GO:0006801 IDA
    superoxide metabolic process GO:0006801 ISS
    intracellular iron ion homeostasis GO:0006879 ISS
    apoptotic process GO:0006915 IEA
    spermatogenesis GO:0007283 ISS
    embryo implantation GO:0007566 ISS
    embryo implantation GO:0007566 NAS
    sensory perception of sound GO:0007605 ISS
    locomotory behavior GO:0007626 ISS
    anterograde axonal transport GO:0008089 ISS
    retrograde axonal transport GO:0008090 ISS
    regulation of blood pressure GO:0008217 ISS
    determination of adult lifespan GO:0008340 IEA
    response to heat GO:0009408 ISS
    response to xenobiotic stimulus GO:0009410 IEA
    gene expression GO:0010467 IEA
    transmission of nerve impulse GO:0019226 ISS
    neuronal action potential GO:0019228 IEA
    removal of superoxide radicals GO:0019430 IBA
    removal of superoxide radicals GO:0019430 IDA
    removal of superoxide radicals GO:0019430 ISS
    peripheral nervous system myelin maintenance GO:0032287 ISS
    positive regulation of superoxide anion generation GO:0032930 IDA
    regulation of T cell differentiation in thymus GO:0033081 NAS
    ectopic germ cell programmed cell death GO:0035234 IEA
    regulation of multicellular organism growth GO:0040014 ISS
    response to hydrogen peroxide GO:0042542 ISS
    superoxide anion generation GO:0042554 IEA
    positive regulation of apoptotic process GO:0043065 IC
    regulation of GTPase activity GO:0043087 IDA
    positive regulation of MAPK cascade GO:0043410 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    response to ethanol GO:0045471 ISS
    regulation of organ growth GO:0046620 NAS
    muscle cell cellular homeostasis GO:0046716 ISS
    thymus development GO:0048538 NAS
    response to axon injury GO:0048678 ISS
    hydrogen peroxide biosynthetic process GO:0050665 IDA
    hydrogen peroxide biosynthetic process GO:0050665 ISS
    negative regulation of inflammatory response GO:0050728 IEA
    positive regulation of phagocytosis GO:0050766 IEA
    negative regulation of developmental process GO:0051093 IEA
    regulation of mitochondrial membrane potential GO:0051881 IMP
    heart contraction GO:0060047 IDA
    neurofilament cytoskeleton organization GO:0060052 ISS
    relaxation of vascular associated smooth muscle GO:0060087 ISS
    auditory receptor cell stereocilium organization GO:0060088 ISS
    reactive oxygen species metabolic process GO:0072593 IDA
    action potential initiation GO:0099610 IEA
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 IMP
    negative regulation of reproductive process GO:2000242 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial intermembrane space GO:0005758 TAS
    mitochondrial matrix GO:0005759 NAS
    peroxisome GO:0005777 IBA
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    cytoplasmic vesicle GO:0031410 IDA
    dendrite cytoplasm GO:0032839 IDA
    protein-containing complex GO:0032991 IDA
    neuronal cell body GO:0043025 IDA
    extracellular exosome GO:0070062 HDA
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified SOD1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
12
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
25
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
26
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 219
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 220
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 221
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
34
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
35
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
38
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
42
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
44
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
46
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
47
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
48
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
49
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
50
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SOD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF3A 8661
Affinity Capture-MS Homo sapiens
2 GSTZ1 2954
Co-fractionation Homo sapiens
3 PRDX5 25824
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
4 OXCT1 5019
Co-fractionation Homo sapiens
5 PTMS 5763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LDHB 3945
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
7 LACTB2 51110
Co-fractionation Homo sapiens
8 Stub1 56424
Affinity Capture-Western Mus musculus
9 UBA1 7317
Affinity Capture-MS Homo sapiens
10 UBE3A 7337
Reconstituted Complex Homo sapiens
11 UBC 7316
Affinity Capture-Western Homo sapiens
12 PPIAL4A 653505
Affinity Capture-MS Homo sapiens
13 PARK7 11315
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
14 DECR1 1666
Co-fractionation Homo sapiens
15 CKB 1152
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DARS 1615
Affinity Capture-MS Homo sapiens
17 Hspa4 15525
Affinity Capture-MS Mus musculus
18 CCS 9973
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
19 GDI1 2664
Affinity Capture-MS Homo sapiens
20 CPSF7 79869
Affinity Capture-MS Homo sapiens
21 HEXB 3074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 MARCH5  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
23 RHOA 387
Affinity Capture-MS Homo sapiens
24 EIF3E 3646
Affinity Capture-MS Homo sapiens
25 PPM1A 5494
Affinity Capture-MS Homo sapiens
26 MARCKSL1 65108
Affinity Capture-MS Homo sapiens
27 OPTN 10133
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 POLR2C 5432
Proximity Label-MS Homo sapiens
29 NDUFAB1 4706
Co-fractionation Homo sapiens
30 KDELC2 143888
Co-fractionation Homo sapiens
31 SOD1 6647
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
32 DYNLT1 6993
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
33 C11orf54 28970
Co-fractionation Homo sapiens
34 AARS 16
Affinity Capture-MS Homo sapiens
35 PPM1B 5495
Affinity Capture-MS Homo sapiens
36 PDP1 54704
Co-fractionation Homo sapiens
37 SAE1 10055
Affinity Capture-MS Homo sapiens
38 LDHC 3948
Co-fractionation Homo sapiens
39 PSMD2 5708
Affinity Capture-MS Homo sapiens
40 ACTN4 81
Affinity Capture-MS Homo sapiens
41 SPR 6697
Co-fractionation Homo sapiens
42 NOS2  
Co-fractionation Homo sapiens
43 BANF1 8815
Affinity Capture-MS Homo sapiens
44 YWHAQ 10971
Affinity Capture-MS Homo sapiens
45 ENO1 2023
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
46 DDX39B 7919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SND1 27044
Affinity Capture-MS Homo sapiens
48 SSR4 6748
Affinity Capture-Western Homo sapiens
49 TXN2 25828
Co-fractionation Homo sapiens
50 S100A11 6282
Affinity Capture-MS Homo sapiens
51 HSPA5 3309
Proximity Label-MS Homo sapiens
52 EPDR1 54749
Affinity Capture-MS Homo sapiens
53 Hspa8 15481
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
54 MOB1B 92597
Affinity Capture-MS Homo sapiens
55 UFC1 51506
Co-fractionation Homo sapiens
56 MLLT10  
Affinity Capture-MS Homo sapiens
57 AHCYL1 10768
Co-fractionation Homo sapiens
58 LMNB1 4001
Affinity Capture-MS Homo sapiens
59 CRYAB 1410
Reconstituted Complex Homo sapiens
60 ANXA1 301
Affinity Capture-MS Homo sapiens
61 DES 1674
Affinity Capture-MS Homo sapiens
62 ARCN1 372
Co-fractionation Homo sapiens
63 EEF1B2 1933
Affinity Capture-MS Homo sapiens
64 CDC42 998
Affinity Capture-MS Homo sapiens
65 GLO1 2739
Affinity Capture-MS Homo sapiens
66 Hsph1 15505
Affinity Capture-MS Mus musculus
67 PCBP1 5093
Co-fractionation Homo sapiens
68 RPA3 6119
Affinity Capture-MS Homo sapiens
69 NME1 4830
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
70 LDHAL6B 92483
Co-fractionation Homo sapiens
71 GSTK1 373156
Affinity Capture-MS Homo sapiens
72 HSPA4 3308
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
73 PSMC5 5705
Affinity Capture-MS Homo sapiens
74 STMN1 3925
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ACY1 95
Co-fractionation Homo sapiens
76 TBCA 6902
Affinity Capture-MS Homo sapiens
77 PABPC3 5042
Co-fractionation Homo sapiens
78 COMMD1 150684
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
79 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 HSPE1 3336
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 EIF3I 8668
Affinity Capture-MS Homo sapiens
82 RUVBL2 10856
Affinity Capture-MS Homo sapiens
83 PCMT1 5110
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
84 SUCLG2 8801
Co-fractionation Homo sapiens
85 APRT 353
Affinity Capture-MS Homo sapiens
86 TKT 7086
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 OAT 4942
Co-fractionation Homo sapiens
88 MCM5 4174
Affinity Capture-MS Homo sapiens
89 GAPDH 2597
Co-fractionation Homo sapiens
90 BCL2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
91 ACO2 50
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
92 CEP78 84131
Affinity Capture-MS Homo sapiens
93 ADRM1 11047
Affinity Capture-MS Homo sapiens
94 Hspa5 14828
Affinity Capture-MS Mus musculus
95 NOP10 55505
Affinity Capture-MS Homo sapiens
96 GSTP1 2950
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
97 ACOT7 11332
Affinity Capture-MS Homo sapiens
98 LDHA 3939
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
99 MCM3 4172
Affinity Capture-MS Homo sapiens
100 GNPDA2 132789
Co-fractionation Homo sapiens
101 KLC2 64837
Affinity Capture-MS Homo sapiens
102 ANP32A 8125
Affinity Capture-MS Homo sapiens
103 NACA 4666
Affinity Capture-MS Homo sapiens
104 ALB 213
Affinity Capture-MS Homo sapiens
105 UCHL1 7345
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
106 LGALS1 3956
Co-fractionation Homo sapiens
107 HSP90AB1 3326
Affinity Capture-Luminescence Homo sapiens
108 NENF 29937
Co-fractionation Homo sapiens
109 COPA 1314
Affinity Capture-MS Homo sapiens
110 GRHPR 9380
Co-fractionation Homo sapiens
111 PGK1 5230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 CLDN17  
Affinity Capture-MS Homo sapiens
113 H1FX 8971
Affinity Capture-MS Homo sapiens
114 SPIN1  
Affinity Capture-MS Homo sapiens
115 MTHFD1 4522
Affinity Capture-MS Homo sapiens
116 HIBCH 26275
Co-fractionation Homo sapiens
117 NUP93 9688
Affinity Capture-MS Homo sapiens
118 PRDX2 7001
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
119 STIP1 10963
Co-fractionation Homo sapiens
120 AASDHPPT 60496
Affinity Capture-MS Homo sapiens
121 TIAL1 7073
Co-fractionation Homo sapiens
122 AKR1B15  
Co-fractionation Homo sapiens
123 CCT7 10574
Affinity Capture-MS Homo sapiens
124 PSAP 5660
Affinity Capture-MS Homo sapiens
125 PLS3 5358
Co-fractionation Homo sapiens
126 YWHAB 7529
Affinity Capture-MS Homo sapiens
127 CCT2 10576
Affinity Capture-MS Homo sapiens
128 PFN1 5216
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 CEP55 55165
Affinity Capture-MS Homo sapiens
130 AMFR 267
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
131 RAB21 23011
Affinity Capture-MS Homo sapiens
132 COPG1 22820
Affinity Capture-MS Homo sapiens
133 TMEM189-UBE2V1 387522
Co-fractionation Homo sapiens
134 PHKA1 5255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 PSMD14 10213
Affinity Capture-MS Homo sapiens
136 TRIM24  
Affinity Capture-MS Homo sapiens
137 RAP1A 5906
Affinity Capture-MS Homo sapiens
138 PPP2CA 5515
Co-fractionation Homo sapiens
139 ATP6V1B1 525
Affinity Capture-MS Homo sapiens
140 AKR1A1 10327
Co-fractionation Homo sapiens
141 RGN 9104
Co-fractionation Homo sapiens
142 CAT 847
Co-fractionation Homo sapiens
143 ALDH7A1 501
Affinity Capture-MS Homo sapiens
144 CANX 821
Cross-Linking-MS (XL-MS) Homo sapiens
145 TPR 7175
Affinity Capture-MS Homo sapiens
146 PPA1 5464
Affinity Capture-MS Homo sapiens
147 UBE2L3 7332
Co-fractionation Homo sapiens
148 POLR2E 5434
Affinity Capture-MS Homo sapiens
149 EGFR 1956
Negative Genetic Homo sapiens
150 SORD 6652
Co-fractionation Homo sapiens
151 LARS 51520
Affinity Capture-MS Homo sapiens
152 SPTBN1 6711
Co-fractionation Homo sapiens
153 SCYL2 55681
Co-fractionation Homo sapiens
154 PPIL3 53938
Co-fractionation Homo sapiens
155 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
156 BAG1 573
Affinity Capture-MS Homo sapiens
157 PMP2  
Co-fractionation Homo sapiens
158 SET 6418
Affinity Capture-MS Homo sapiens
159 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
160 DSTN 11034
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
161 DDRGK1 65992
Affinity Capture-MS Homo sapiens
162 PGAM1 5223
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
163 FKBP1B  
Co-fractionation Homo sapiens
164 LMNA 4000
Affinity Capture-MS Homo sapiens
165 RAE1 8480
Co-fractionation Homo sapiens
166 HUWE1 10075
Affinity Capture-MS Homo sapiens
167 PPIF 10105
Co-fractionation Homo sapiens
168 PRKCSH 5589
Affinity Capture-MS Homo sapiens
169 NUTF2 10204
Co-fractionation Homo sapiens
170 TANGO2  
Co-fractionation Homo sapiens
171 HMGB1 3146
Affinity Capture-MS Homo sapiens
172 FEN1 2237
Affinity Capture-MS Homo sapiens
173 PDCD6IP 10015
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
174 EIF1AX 1964
Affinity Capture-MS Homo sapiens
175 CRIP1 1396
Co-fractionation Homo sapiens
176 SRP19 6728
Affinity Capture-MS Homo sapiens
177 BCL2L13 23786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 TAGLN2 8407
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
179 EEF1D 1936
Affinity Capture-MS Homo sapiens
180 DBI 1622
Co-fractionation Homo sapiens
181 STXBP2 6813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 ATP1A1 476
Affinity Capture-MS Homo sapiens
183 GOT1 2805
Co-fractionation Homo sapiens
184 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
185 AP3D1 8943
Affinity Capture-MS Homo sapiens
186 HMGB3 3149
Affinity Capture-MS Homo sapiens
187 TIMM13 26517
Affinity Capture-MS Homo sapiens
188 PSMA6 5687
Affinity Capture-MS Homo sapiens
189 EEF1G 1937
Affinity Capture-MS Homo sapiens
190 MARCKS 4082
Affinity Capture-MS Homo sapiens
191 PTMA 5757
Affinity Capture-MS Homo sapiens
192 POFUT1 23509
Co-fractionation Homo sapiens
193 PSME2 5721
Affinity Capture-MS Homo sapiens
194 YWHAE 7531
Affinity Capture-MS Homo sapiens
195 PHF21A  
Affinity Capture-MS Homo sapiens
196 SSB 6741
Affinity Capture-MS Homo sapiens
197 SYNE2 23224
Affinity Capture-MS Homo sapiens
198 PEBP1 5037
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
199 ADK 132
Co-fractionation Homo sapiens
200 RUVBL1 8607
Affinity Capture-MS Homo sapiens
201 TRIM28 10155
Affinity Capture-MS Homo sapiens
202 CRYZ 1429
Affinity Capture-MS Homo sapiens
203 MCM2 4171
Affinity Capture-MS Homo sapiens
204 DAZAP1 26528
Co-fractionation Homo sapiens
205 CHCHD2  
Affinity Capture-MS Homo sapiens
206 AHSG 197
Affinity Capture-MS Homo sapiens
207 HINT2 84681
Co-fractionation Homo sapiens
208 IQGAP1 8826
Affinity Capture-MS Homo sapiens
209 MCM6 4175
Affinity Capture-MS Homo sapiens
210 PSMC2 5701
Affinity Capture-MS Homo sapiens
211 PDIA6 10130
Affinity Capture-MS Homo sapiens
212 PRDX4 10549
Affinity Capture-MS Homo sapiens
213 CALR 811
Affinity Capture-MS Homo sapiens
214 LDHAL6A  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
215 MAVS 57506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 COX17  
Co-fractionation Homo sapiens
217 PABPC4 8761
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
218 RBM8A 9939
Affinity Capture-MS Homo sapiens
219 HSPA8 3312
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
220 MDH2 4191
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 UBE2V1 7335
Co-fractionation Homo sapiens
222 NSUN2 54888
Affinity Capture-MS Homo sapiens
223 SUCLG1 8802
Co-fractionation Homo sapiens
224 PRPH 5630
Affinity Capture-MS Homo sapiens
225 CENPV 201161
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
226 TKTL2  
Co-fractionation Homo sapiens
227 FUBP1 8880
Affinity Capture-MS Homo sapiens
228 TPI1 7167
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
229 SMAD2 4087
Reconstituted Complex Homo sapiens
230 ACTB 60
Co-fractionation Homo sapiens
231 EIF3H 8667
Affinity Capture-MS Homo sapiens
232 NUDC 10726
Co-fractionation Homo sapiens
233 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
234 Hspa4l  
Affinity Capture-MS Mus musculus
235 MAP4K1  
Affinity Capture-MS Homo sapiens
236 CBFB 865
Co-fractionation Homo sapiens
237 ACAT1 38
Affinity Capture-MS Homo sapiens
238 GLOD4 51031
Co-fractionation Homo sapiens
239 HSPA9 3313
Co-fractionation Homo sapiens
240 AK2 204
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
241 TRIM33 51592
Affinity Capture-MS Homo sapiens
242 NME1-NME2 654364
Co-fractionation Homo sapiens
243 ASCC1 51008
Affinity Capture-MS Homo sapiens
244 EEF2 1938
Affinity Capture-MS Homo sapiens
245 TAB1 10454
Affinity Capture-MS Homo sapiens
246 LMNB2 84823
Affinity Capture-MS Homo sapiens
247 ANXA5 308
Affinity Capture-MS Homo sapiens
248 PSMA2 5683
Affinity Capture-MS Homo sapiens
249 H1F0 3005
Affinity Capture-MS Homo sapiens
250 BASP1 10409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
251 AKR1B1 231
Co-fractionation Homo sapiens
252 AKR1C2  
Co-fractionation Homo sapiens
253 FDX1 2230
Co-fractionation Homo sapiens
254 PGM5 5239
Co-fractionation Homo sapiens
255 P4HB 5034
Affinity Capture-MS Homo sapiens
256 RAB9A 9367
Affinity Capture-MS Homo sapiens
257 CFL2 1073
Co-fractionation Homo sapiens
258 ENO2 2026
Co-fractionation Homo sapiens
259 MPI 4351
Co-fractionation Homo sapiens
260 HINT1 3094
Affinity Capture-MS Homo sapiens
261 RPRD1B 58490
Affinity Capture-MS Homo sapiens
262 XRCC5 7520
Affinity Capture-MS Homo sapiens
263 TPM3 7170
Affinity Capture-MS Homo sapiens
264 EIF2S1 1965
Affinity Capture-MS Homo sapiens
265 SUMF2 25870
Co-fractionation Homo sapiens
266 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
267 CCT8 10694
Affinity Capture-MS Homo sapiens
268 SOD2 6648
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
269 Sod1 20655
Affinity Capture-MS Mus musculus
270 HECW1  
Affinity Capture-Western Homo sapiens
271 CUTA 51596
Affinity Capture-MS Homo sapiens
272 MTPN 136319
Affinity Capture-MS Homo sapiens
273 GPI 2821
Co-fractionation Homo sapiens
274 PIN1 5300
Co-fractionation Homo sapiens
275 GNB1 2782
Affinity Capture-MS Homo sapiens
276 IDH3A 3419
Affinity Capture-MS Homo sapiens
277 TRAP1 10131
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
278 MIF 4282
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
279 DNM1L 10059
Affinity Capture-MS Homo sapiens
280 API5 8539
Affinity Capture-MS Homo sapiens
281 PRDX6 9588
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
282 FKBP1A 2280
Co-fractionation Homo sapiens
283 C14orf166 51637
Affinity Capture-MS Homo sapiens
284 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
285 FABP7  
Co-fractionation Homo sapiens
286 UBE2H 7328
Affinity Capture-MS Homo sapiens
287 FABP3 2170
Co-fractionation Homo sapiens
288 RIT1 6016
Negative Genetic Homo sapiens
289 ATPIF1 93974
Affinity Capture-MS Homo sapiens
290 FKBP7 51661
Co-fractionation Homo sapiens
291 CPOX 1371
Co-fractionation Homo sapiens
292 RPL30 6156
Affinity Capture-MS Homo sapiens
293 PSMD11 5717
Affinity Capture-MS Homo sapiens
294 UBE2M 9040
Affinity Capture-MS Homo sapiens
295 KPNB1 3837
Affinity Capture-MS Homo sapiens
296 USP9X 8239
Affinity Capture-MS Homo sapiens
297 ETFB 2109
Affinity Capture-MS Homo sapiens
298 PPIA 5478
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
299 CALM1 801
Affinity Capture-MS Homo sapiens
300 PIR 8544
Co-fractionation Homo sapiens
301 CFL1 1072
Co-fractionation Homo sapiens
302 ILF2 3608
Affinity Capture-MS Homo sapiens
303 Hspa2 15512
Affinity Capture-MS Mus musculus
304 PDXK 8566
Co-fractionation Homo sapiens
305 PITPNB 23760
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
306 KIF5B 3799
Affinity Capture-MS Homo sapiens
307 GLRX 2745
Co-fractionation Homo sapiens
308 ANP32B 10541
Affinity Capture-MS Homo sapiens
309 Hspa1b 15511
Affinity Capture-MS Mus musculus
310 IMPDH2 3615
Affinity Capture-MS Homo sapiens
311 PGM1 5236
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
312 MRPL12 6182
Affinity Capture-MS Homo sapiens
313 YWHAG 7532
Affinity Capture-MS Homo sapiens
314 PGLS 25796
Co-fractionation Homo sapiens
315 Ccs  
Affinity Capture-MS Mus musculus
316 FDX1L  
Co-fractionation Homo sapiens
317 SERPINH1 871
Affinity Capture-MS Homo sapiens
318 SRI 6717
Co-fractionation Homo sapiens
319 VAT1 10493
Affinity Capture-MS Homo sapiens
320 NAP1L4 4676
Affinity Capture-MS Homo sapiens
321 NME2 4831
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
322 PRCC  
Affinity Capture-MS Homo sapiens
323 PSMC6 5706
Affinity Capture-MS Homo sapiens
324 GSTO1 9446
Co-fractionation Homo sapiens
325 SARS 6301
Affinity Capture-MS Homo sapiens
326 NEDD4 4734
Affinity Capture-MS Homo sapiens
327 ADSL 158
Co-fractionation Homo sapiens
328 PPIB 5479
Affinity Capture-MS Homo sapiens
329 C1orf86  
Affinity Capture-MS Homo sapiens
330 COLEC10 10584
Co-fractionation Homo sapiens
331 PSMD4 5710
Affinity Capture-Western Homo sapiens
332 CCAR2 57805
Affinity Capture-MS Homo sapiens
333 HIVEP1 3096
Affinity Capture-MS Homo sapiens
334 HSP90B1 7184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
335 PSMC1 5700
Affinity Capture-MS Homo sapiens
336 RPE  
Co-fractionation Homo sapiens
337 TPD52 7163
Affinity Capture-MS Homo sapiens
338 PFDN2 5202
Affinity Capture-MS Homo sapiens
339 APOL2 23780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
340 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
341 HMGN1  
Affinity Capture-MS Homo sapiens
342 SUMO2 6613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
343 GANAB 23193
Affinity Capture-MS Homo sapiens
344 MYH11 4629
Affinity Capture-MS Homo sapiens
345 HRNR 388697
Affinity Capture-MS Homo sapiens
346 CLIC4 25932
Co-fractionation Homo sapiens
347 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
348 ENO3 2027
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
349 MAT2A 4144
Affinity Capture-MS Homo sapiens
350 UBE2N 7334
Affinity Capture-MS Homo sapiens
351 HAGH 3029
Affinity Capture-MS Homo sapiens
352 PSMB6 5694
Affinity Capture-MS Homo sapiens
353 YWHAZ 7534
Affinity Capture-MS Homo sapiens
354 STXBP1 6812
Affinity Capture-MS Homo sapiens
355 EXOSC6 118460
Affinity Capture-MS Homo sapiens
356 GCSH 2653
Co-fractionation Homo sapiens
357 PRDX1 5052
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
358 NFS1 9054
Affinity Capture-MS Homo sapiens
359 RNF19A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
360 PDIA3 2923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
361 MCM4 4173
Affinity Capture-MS Homo sapiens
362 FABP5 2171
Co-fractionation Homo sapiens
363 HIBADH 11112
Co-fractionation Homo sapiens
364 ATP6V1A 523
Affinity Capture-MS Homo sapiens
365 TXNL1 9352
Co-fractionation Homo sapiens
366 EPRS 2058
Affinity Capture-MS Homo sapiens
367 LGMN 5641
Affinity Capture-MS Homo sapiens
368 SERPINB5 5268
Co-fractionation Homo sapiens
369 EIF3D 8664
Affinity Capture-MS Homo sapiens
370 CLIC1 1192
Co-fractionation Homo sapiens
371 ASNS 440
Co-fractionation Homo sapiens
372 PDIA4 9601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
373 LGALS3 3958
Co-fractionation Homo sapiens
374 GPX4 2879
Co-fractionation Homo sapiens
375 Dnaja1 15502
Affinity Capture-MS Mus musculus
376 ELAVL1 1994
Affinity Capture-MS Homo sapiens
377 EIF4A3 9775
Affinity Capture-MS Homo sapiens
378 ADPRHL2 54936
Co-fractionation Homo sapiens
379 PRR12 57479
Affinity Capture-MS Homo sapiens
380 TXN 7295
Co-fractionation Homo sapiens
381 TRIP4 9325
Affinity Capture-MS Homo sapiens
382 QDPR 5860
Co-fractionation Homo sapiens
383 XRCC6 2547
Affinity Capture-MS Homo sapiens
384 EIF5A 1984
Affinity Capture-MS Homo sapiens
385 ATOX1 475
Co-fractionation Homo sapiens
386 UFM1 51569
Co-fractionation Homo sapiens
387 ALDOA 226
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here