Gene description for PTMS
Gene name parathymosin
Gene symbol PTMS
Other names/aliases ParaT
Species Homo sapiens
 Database cross references - PTMS
ExoCarta ExoCarta_5763
Vesiclepedia VP_5763
Entrez Gene 5763
HGNC 9629
MIM 168440
UniProt P20962  
 PTMS identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
 Gene ontology annotations for PTMS
Molecular Function
    histone binding GO:0042393 IBA
Biological Process
    immune system process GO:0002376 IEA
    DNA replication GO:0006260 TAS
    negative regulation of apoptotic process GO:0043066 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified PTMS in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PTMS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAB 7529
Affinity Capture-MS Homo sapiens
2 Ccdc15  
Affinity Capture-MS Mus musculus
3 HSPE1 3336
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
4 CALR 811
Affinity Capture-MS Homo sapiens
5 SCHIP1  
Reconstituted Complex Homo sapiens
6 OXCT1 5019
Co-fractionation Homo sapiens
7 PRKCSH 5589
Affinity Capture-MS Homo sapiens
8 ATPIF1 93974
Affinity Capture-MS Homo sapiens
9 ADSS 159
Co-fractionation Homo sapiens
10 NEDD4 4734
Affinity Capture-MS Homo sapiens
11 IDH1 3417
Co-fractionation Homo sapiens
12 DCK 1633
Co-fractionation Homo sapiens
13 ANP32A 8125
Affinity Capture-MS Homo sapiens
14 RBM8A 9939
Affinity Capture-MS Homo sapiens
15 MARCKS 4082
Affinity Capture-MS Homo sapiens
16 Pds5a  
Affinity Capture-MS Mus musculus
17 SDCBP2 27111
Two-hybrid Homo sapiens
18 NUBP2 10101
Co-fractionation Homo sapiens
19 PTMA 5757
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
20 PDIA4 9601
Affinity Capture-MS Homo sapiens
21 TALDO1 6888
Co-fractionation Homo sapiens
22 EIF6 3692
Affinity Capture-MS Homo sapiens
23 TAL1  
Proximity Label-MS Homo sapiens
24 NACA 4666
Affinity Capture-MS Homo sapiens
25 ACTC1 70
Affinity Capture-MS Homo sapiens
26 WDR1 9948
Co-fractionation Homo sapiens
27 THOP1 7064
Co-fractionation Homo sapiens
28 MIF 4282
Affinity Capture-MS Homo sapiens
29 PRDX5 25824
Co-fractionation Homo sapiens
30 NR3C1 2908
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
31 PSIP1 11168
Affinity Capture-MS Homo sapiens
32 PDIA3 2923
Affinity Capture-MS Homo sapiens
33 PHPT1 29085
Co-fractionation Homo sapiens
34 CALM1 801
Affinity Capture-MS Homo sapiens
35 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 TKT 7086
Affinity Capture-MS Homo sapiens
37 PFN1 5216
Affinity Capture-MS Homo sapiens
38 PEBP1 5037
Affinity Capture-MS Homo sapiens
39 Haus6  
Affinity Capture-MS Mus musculus
40 DDX58 23586
Affinity Capture-RNA Homo sapiens
41 CLNS1A 1207
Co-fractionation Homo sapiens
42 ITGA6 3655
Cross-Linking-MS (XL-MS) Homo sapiens
43 APP 351
Reconstituted Complex Homo sapiens
44 ANP32B 10541
Affinity Capture-MS Homo sapiens
45 BASP1 10409
Affinity Capture-MS Homo sapiens
46 TRIM24  
Affinity Capture-MS Homo sapiens
47 NUDCD2 134492
Co-fractionation Homo sapiens
48 CBX3 11335
Co-fractionation Homo sapiens
49 Plk4  
Affinity Capture-MS Mus musculus
50 PGK1 5230
Affinity Capture-MS Homo sapiens
51 LAGE3  
Co-fractionation Homo sapiens
52 SMAD2 4087
Reconstituted Complex Homo sapiens
53 HMGN1  
Affinity Capture-MS Homo sapiens
54 TPM3 7170
Affinity Capture-MS Homo sapiens
55 EEF1A1P5 158078
Cross-Linking-MS (XL-MS) Homo sapiens
56 ANXA5 308
Affinity Capture-MS Homo sapiens
57 SUMO2 6613
Affinity Capture-MS Homo sapiens
58 RPRD1B 58490
Affinity Capture-MS Homo sapiens
59 DSTN 11034
Co-fractionation Homo sapiens
60 STMN1 3925
Affinity Capture-MS Homo sapiens
61 FKBP3 2287
Affinity Capture-MS Homo sapiens
62 RBBP7 5931
Co-fractionation Homo sapiens
63 PARK7 11315
Affinity Capture-MS Homo sapiens
64 RXRB 6257
Reconstituted Complex Homo sapiens
65 PGAM1 5223
Affinity Capture-MS Homo sapiens
66 KLF15  
Affinity Capture-MS Homo sapiens
67 HSPD1 3329
Co-fractionation Homo sapiens
68 HMGB2 3148
Affinity Capture-MS Homo sapiens
69 DDX39B 7919
Affinity Capture-MS Homo sapiens
70 PRDX3 10935
Affinity Capture-MS Homo sapiens
71 FOXQ1  
Proximity Label-MS Homo sapiens
72 HMGB1P1 10357
Affinity Capture-MS Homo sapiens
73 SOD1 6647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
75 PPIB 5479
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PTMS is involved
No pathways found





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