Gene description for FKBP3
Gene name FK506 binding protein 3, 25kDa
Gene symbol FKBP3
Other names/aliases FKBP-25
FKBP-3
FKBP25
PPIase
Species Homo sapiens
 Database cross references - FKBP3
ExoCarta ExoCarta_2287
Entrez Gene 2287
HGNC 3719
MIM 186947
UniProt Q00688  
 FKBP3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FKBP3
Molecular Function
    FK506 binding GO:0005528 TAS
    receptor activity GO:0004872 TAS
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    protein peptidyl-prolyl isomerization GO:0000413 IBA
    chaperone-mediated protein folding GO:0061077 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    endoplasmic reticulum membrane GO:0005789 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified FKBP3 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FKBP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC2 3066
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
2 HDAC1 3065
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 YY1 7528
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 MTA2 9219
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which FKBP3 is involved
No pathways found





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