Gene description for Nedd4
Gene name	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene symbol	Nedd4
Other names/aliases	Nedd4a
Species	Rattus norvegicus
Database cross references - Nedd4
ExoCarta	ExoCarta_25489
Vesiclepedia	VP_25489
Entrez Gene	25489
UniProt	Q62940
Nedd4 identified in exosomes derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Nedd4

Molecular Function     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin-protein transferase activity GO:0004842 IEA     protein binding GO:0005515 IPI     sodium channel inhibitor activity GO:0019871 IBA     sodium channel inhibitor activity GO:0019871 IEA     sodium channel inhibitor activity GO:0019871 ISO     enzyme binding GO:0019899 ISO     protein domain specific binding GO:0019904 IEA     protein domain specific binding GO:0019904 ISO     beta-2 adrenergic receptor binding GO:0031698 IEA     beta-2 adrenergic receptor binding GO:0031698 ISO     ionotropic glutamate receptor binding GO:0035255 ISO     ubiquitin binding GO:0043130 IEA     ubiquitin binding GO:0043130 ISO     phosphoserine residue binding GO:0050815 ISO     phosphothreonine residue binding GO:0050816 ISO     ubiquitin protein ligase activity GO:0061630 IBA     ubiquitin protein ligase activity GO:0061630 IEA     ubiquitin protein ligase activity GO:0061630 ISO     ubiquitin protein ligase activity GO:0061630 ISS     RNA polymerase binding GO:0070063 IEA     RNA polymerase binding GO:0070063 ISO     proline-rich region binding GO:0070064 IEA     proline-rich region binding GO:0070064 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     adaptive immune response GO:0002250 ISO     outflow tract morphogenesis GO:0003151 ISO     endocardial cushion development GO:0003197 ISO     ubiquitin-dependent protein catabolic process GO:0006511 IBA     ubiquitin-dependent protein catabolic process GO:0006511 IEA     ubiquitin-dependent protein catabolic process GO:0006511 ISO     ubiquitin-dependent protein catabolic process GO:0006511 ISO     ubiquitin-dependent protein catabolic process GO:0006511 ISS     protein monoubiquitination GO:0006513 ISO     protein targeting to lysosome GO:0006622 IEA     protein targeting to lysosome GO:0006622 ISO     sodium ion transport GO:0006814 ISO     immune response GO:0006955 IEP     DNA damage response GO:0006974 IEA     DNA damage response GO:0006974 ISO     lysosomal transport GO:0007041 ISO     neuromuscular junction development GO:0007528 IBA     neuromuscular junction development GO:0007528 ISO     negative regulation of sodium ion transport GO:0010766 IEA     negative regulation of sodium ion transport GO:0010766 ISO     negative regulation of sodium ion transport GO:0010766 ISO     response to denervation involved in regulation of muscle adaptation GO:0014894 IEP     protein ubiquitination GO:0016567 IEA     protein ubiquitination GO:0016567 ISO     protein ubiquitination GO:0016567 ISO     protein ubiquitination GO:0016567 ISS     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 ISO     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 ISS     neuron projection development GO:0031175 IBA     neuron projection development GO:0031175 IEA     neuron projection development GO:0031175 ISO     receptor internalization GO:0031623 IBA     receptor internalization GO:0031623 IEA     receptor internalization GO:0031623 ISO     receptor catabolic process GO:0032801 IBA     receptor catabolic process GO:0032801 IEA     receptor catabolic process GO:0032801 ISO     cellular response to UV GO:0034644 IEA     cellular response to UV GO:0034644 ISO     regulation of monoatomic ion transmembrane transport GO:0034765 IEA     regulation of monoatomic ion transmembrane transport GO:0034765 ISO     T cell activation GO:0042110 ISO     regulation of membrane potential GO:0042391 IEA     regulation of membrane potential GO:0042391 ISO     nuclear receptor-mediated glucocorticoid signaling pathway GO:0042921 IEA     nuclear receptor-mediated glucocorticoid signaling pathway GO:0042921 ISO     ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IEA     ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISO     formation of structure involved in a symbiotic process GO:0044111 IEA     innate immune response GO:0045087 IEA     innate immune response GO:0045087 ISO     positive regulation of protein catabolic process GO:0045732 IEA     positive regulation of protein catabolic process GO:0045732 ISO     viral budding GO:0046755 IEA     positive regulation of nucleocytoplasmic transport GO:0046824 IEA     positive regulation of nucleocytoplasmic transport GO:0046824 ISO     blood vessel morphogenesis GO:0048514 ISO     regulation of dendrite morphogenesis GO:0048814 IBA     regulation of dendrite morphogenesis GO:0048814 IDA     regulation of dendrite morphogenesis GO:0048814 ISO     regulation of synapse organization GO:0050807 IBA     regulation of synapse organization GO:0050807 ISO     progesterone receptor signaling pathway GO:0050847 IEA     progesterone receptor signaling pathway GO:0050847 ISO     establishment of localization in cell GO:0051649 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     protein K63-linked ubiquitination GO:0070534 IDA     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IDA     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IEP     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IMP     regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 IDA     regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 IEP     regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 IMP     regulation protein catabolic process at postsynapse GO:0140252 IDA     regulation protein catabolic process at postsynapse GO:0140252 IEP     regulation protein catabolic process at postsynapse GO:0140252 IMP     regulation of potassium ion transmembrane transporter activity GO:1901016 ISO     negative regulation of sodium ion transmembrane transporter activity GO:2000650 ISO Subcellular Localization     ubiquitin ligase complex GO:0000151 ISO     chromatin GO:0000785 IEA     chromatin GO:0000785 ISO     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     microvillus GO:0005902 IDA     cell cortex GO:0005938 IEA     cell cortex GO:0005938 ISO     membrane GO:0016020 ISO     protein-containing complex GO:0032991 IEA     protein-containing complex GO:0032991 ISO     dendritic spine GO:0043197 IBA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP     glutamatergic synapse GO:0098978 ISO     postsynaptic cytosol GO:0099524 ISO