Gene description for ABL1
Gene name	ABL proto-oncogene 1, non-receptor tyrosine kinase
Gene symbol	ABL1
Other names/aliases	ABL JTK7 bcr/abl c-ABL c-ABL1 p150 v-abl
Species	Homo sapiens
Database cross references - ABL1
ExoCarta	ExoCarta_25
Vesiclepedia	VP_25
Entrez Gene	25
HGNC	76
MIM	189980
UniProt	P00519
ABL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for ABL1

Molecular Function     protein binding GO:0005515 IPI     nicotinate-nucleotide adenylyltransferase activity GO:0004515 TAS     receptor binding GO:0005102 IBA     protein C-terminus binding GO:0008022 IPI     magnesium ion binding GO:0000287 IDA     SH3 domain binding GO:0017124 IPI     DNA binding GO:0003677 NAS     manganese ion binding GO:0030145 IDA     proline-rich region binding GO:0070064 IPI     protein tyrosine kinase activity GO:0004713 IDA     actin monomer binding GO:0003785 TAS     syntaxin binding GO:0019905 IPI     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     protein kinase activity GO:0004672 IDA     mitogen-activated protein kinase binding GO:0051019 IPI     ATP binding GO:0005524 IDA     actin filament binding GO:0051015 IEA Biological Process     negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IEA     positive regulation of mitotic cell cycle GO:0045931 IEA     B cell proliferation involved in immune response GO:0002322 IEA     positive regulation of cytosolic calcium ion concentration GO:0007204 IMP     muscle cell differentiation GO:0042692 TAS     regulation of cell motility GO:2000145 TAS     axon guidance GO:0007411 TAS     cerebellum morphogenesis GO:0021587 IEA     response to oxidative stress GO:0006979 IGI     B-1 B cell homeostasis GO:0001922 IEA     positive regulation of apoptotic process GO:0043065 IDA     cell migration GO:0016477 IBA     regulation of actin cytoskeleton reorganization GO:2000249 TAS     substrate adhesion-dependent cell spreading GO:0034446 IEA     peptidyl-tyrosine phosphorylation GO:0018108 TAS     actin filament branching GO:0090135 IEA     activated T cell proliferation GO:0050798 IEA     regulation of cell proliferation GO:0042127 IBA     positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA     spleen development GO:0048536 IEA     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA     regulation of extracellular matrix organization GO:1903053 IEA     blood coagulation GO:0007596 TAS     mismatch repair GO:0006298 TAS     regulation of cell adhesion GO:0030155 TAS     DNA damage induced protein phosphorylation GO:0006975 IDA     negative regulation of endothelial cell apoptotic process GO:2000352 IEA     negative regulation of BMP signaling pathway GO:0030514 IEA     regulation of transcription, DNA-templated GO:0006355 TAS     actin cytoskeleton organization GO:0030036 ISS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     microspike assembly GO:0030035 IEA     cellular response to dopamine GO:1903351 TAS     alpha-beta T cell differentiation GO:0046632 IEA     positive regulation of oxidoreductase activity GO:0051353 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 TAS     regulation of response to DNA damage stimulus GO:2001020 IDA     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA     negative regulation of protein serine/threonine kinase activity GO:0071901 IDA     Bergmann glial cell differentiation GO:0060020 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 IBA     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to oxidative stress GO:0034599 TAS     mitotic nuclear division GO:0007067 TAS     collateral sprouting GO:0048668 IEA     positive regulation of interleukin-2 secretion GO:1900042 IEA     negative regulation of cell-cell adhesion GO:0022408 IEA     positive regulation of neuron death GO:1901216 IEA     signal transduction in response to DNA damage GO:0042770 IDA     innate immune response GO:0045087 TAS     negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA     transitional one stage B cell differentiation GO:0002333 IEA     negative regulation of mitotic cell cycle GO:0045930 IEA     small GTPase mediated signal transduction GO:0007264 TAS     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     negative regulation of phospholipase C activity GO:1900275 IMP     cell differentiation GO:0030154 IBA     peptidyl-tyrosine autophosphorylation GO:0038083 IDA     negative regulation of ubiquitin-protein transferase activity GO:0051444 TAS     negative regulation of cellular senescence GO:2000773 IEA     cell cycle arrest GO:0007050 TAS     cellular response to DNA damage stimulus GO:0006974 IDA     mitochondrial depolarization GO:0051882 TAS     B cell receptor signaling pathway GO:0050853 IEA     positive regulation of interferon-gamma secretion GO:1902715 IEA     thymus development GO:0048538 IEA     autophagy GO:0006914 IEA     cellular protein modification process GO:0006464 NAS     positive regulation of muscle cell differentiation GO:0051149 TAS     regulation of endocytosis GO:0030100 TAS     positive regulation of protein phosphorylation GO:0001934 IMP     epidermal growth factor receptor signaling pathway GO:0007173 IBA     neuromuscular process controlling balance GO:0050885 IEA     positive regulation of osteoblast proliferation GO:0033690 IEA     regulation of autophagy GO:0010506 TAS Subcellular Localization     cell leading edge GO:0031252 IEA     nucleus GO:0005634 TAS     actin cytoskeleton GO:0015629 TAS     nucleolus GO:0005730 IDA     nuclear membrane GO:0031965 IEA     cytoplasm GO:0005737 TAS     mitochondrion GO:0005739 NAS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     perinuclear region of cytoplasm GO:0048471 IDA     nucleoplasm GO:0005654 IDA     cytosol GO:0005829 TAS