Gene description for STAT1
Gene name	signal transducer and activator of transcription 1, 91kDa
Gene symbol	STAT1
Other names/aliases	CANDF7 IMD31A IMD31B IMD31C ISGF-3 STAT91
Species	Homo sapiens
Database cross references - STAT1
ExoCarta	ExoCarta_6772
Entrez Gene	6772
HGNC	11362
MIM	600555
UniProt	P42224
STAT1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Endothelial cells	26027894
Mesenchymal stem cells	Unpublished / Not applicable
Nasopharyngeal carcinoma cells	25857718
Nasopharyngeal carcinoma cells	25857718
Nasopharyngeal carcinoma cells	25857718
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for STAT1

Molecular Function     identical protein binding GO:0042802 IPI     RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity GO:0000983 IDA     enzyme binding GO:0019899 IPI     double-stranded DNA binding GO:0003690 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     signal transducer activity GO:0004871 IEA     RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IDA     protein homodimerization activity GO:0042803 IDA     CCR5 chemokine receptor binding GO:0031730 IEA     tumor necrosis factor receptor binding GO:0005164 IPI     protein binding GO:0005515 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 IDA Biological Process     response to hydrogen peroxide GO:0042542 IEA     blood circulation GO:0008015 ISS     positive regulation of smooth muscle cell proliferation GO:0048661 ISS     metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 ISS     cellular response to interferon-beta GO:0035458 IMP     regulation of type I interferon-mediated signaling pathway GO:0060338 TAS     renal tubule development GO:0061326 IMP     viral process GO:0016032 IEA     response to mechanical stimulus GO:0009612 IEA     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     positive regulation of mesenchymal cell proliferation GO:0002053 ISS     regulation of apoptotic process GO:0042981 TAS     transcription from RNA polymerase II promoter GO:0006366 IDA     response to peptide hormone GO:0043434 ISS     negative regulation of angiogenesis GO:0016525 IMP     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308 ISS     response to exogenous dsRNA GO:0043330 IEA     endothelial cell migration GO:0043542 IMP     tumor necrosis factor-mediated signaling pathway GO:0033209 IDA     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     metanephric mesenchymal cell differentiation GO:0072162 ISS     negative regulation of endothelial cell proliferation GO:0001937 IMP     negative regulation of macrophage fusion GO:0034240 IEA     interferon-gamma-mediated signaling pathway GO:0060333 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS     negative regulation by virus of viral protein levels in host cell GO:0046725 IMP     negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IMP     regulation of transcription from RNA polymerase II promoter GO:0006357 IDA     positive regulation of transcription, DNA-templated GO:0045893 IDA     JAK-STAT cascade GO:0007259 IDA     type I interferon signaling pathway GO:0060337 TAS     defense response to virus GO:0051607 IEA     cellular response to insulin stimulus GO:0032869 IEA     response to cAMP GO:0051591 ISS     cytokine-mediated signaling pathway GO:0019221 TAS     apoptotic process GO:0006915 ISS     response to nutrient GO:0007584 IEA     negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 ISS     response to cytokine GO:0034097 ISS     response to drug GO:0042493 IEA Subcellular Localization     nucleoplasm GO:0005654 TAS     dendrite GO:0030425 ISS     perinuclear region of cytoplasm GO:0048471 IDA     axon GO:0030424 ISS     nucleus GO:0005634 IDA     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA     nucleolus GO:0005730 IDA     nuclear chromatin GO:0000790 IDA