Gene description for LZTR1
Gene name leucine-zipper-like transcription regulator 1
Gene symbol LZTR1
Other names/aliases BTBD29
LZTR-1
SWNTS2
Species Homo sapiens
 Database cross references - LZTR1
ExoCarta ExoCarta_8216
Vesiclepedia VP_8216
Entrez Gene 8216
HGNC 6742
MIM 600574
UniProt Q8N653  
 LZTR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for LZTR1
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IDA
Biological Process
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    negative regulation of Ras protein signal transduction GO:0046580 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    endomembrane system GO:0012505 IDA
    Cul3-RING ubiquitin ligase complex GO:0031463 IDA
    recycling endosome membrane GO:0055038 IDA
 Experiment description of studies that identified LZTR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for LZTR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2B 5431
Two-hybrid Homo sapiens
2 WDFY3 23001
Affinity Capture-MS Homo sapiens
3 TFAP2B  
Two-hybrid Homo sapiens
4 TRIM5 85363
Two-hybrid Homo sapiens
5 RIT1 6016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MCM3 4172
Two-hybrid Homo sapiens
7 TUBGCP4 27229
Two-hybrid Homo sapiens
8 PARD3B 117583
Affinity Capture-MS Homo sapiens
9 NUAK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZNF137P  
Two-hybrid Homo sapiens
11 AIFM3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ZNF175  
Two-hybrid Homo sapiens
13 ANKRD53  
Two-hybrid Homo sapiens
14 PARP1 142
Two-hybrid Homo sapiens
15 MYH13 8735
Affinity Capture-MS Homo sapiens
16 AATF  
Two-hybrid Homo sapiens
17 PTPN9 5780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CKM  
Affinity Capture-MS Homo sapiens
19 NUDT12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MED7  
Two-hybrid Homo sapiens
21 RERE 473
Two-hybrid Homo sapiens
22 WWP1 11059
Two-hybrid Homo sapiens
23 MYH1  
Affinity Capture-MS Homo sapiens
24 CNOT6L 246175
Two-hybrid Homo sapiens
25 ZNF714  
Two-hybrid Homo sapiens
26 E2F8  
Two-hybrid Homo sapiens
27 POLR1B 84172
Two-hybrid Homo sapiens
28 RIT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MYH8 4626
Affinity Capture-MS Homo sapiens
30 SSX4  
Two-hybrid Homo sapiens
31 POLR2E 5434
Two-hybrid Homo sapiens
32 ZNF584  
Two-hybrid Homo sapiens
33 IKBKG 8517
Two-hybrid Homo sapiens
34 ASB12  
Two-hybrid Homo sapiens
35 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
36 ZZZ3  
Two-hybrid Homo sapiens
37 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SND1 27044
Two-hybrid Homo sapiens
39 EIF4A3 9775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ZBTB1  
Two-hybrid Homo sapiens
41 NR1H3  
Two-hybrid Homo sapiens
42 HDAC4  
Two-hybrid Homo sapiens
43 BRD3 8019
Affinity Capture-MS Homo sapiens
44 SUGP2  
Two-hybrid Homo sapiens
45 NCK2 8440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TAF11  
Two-hybrid Homo sapiens
47 GOLGA2 2801
Co-localization Homo sapiens
48 MED16 10025
Two-hybrid Homo sapiens
49 TCF19  
Two-hybrid Homo sapiens
50 PYGM 5837
Affinity Capture-MS Homo sapiens
51 RUVBL1 8607
Two-hybrid Homo sapiens
52 L3MBTL3  
Two-hybrid Homo sapiens
53 STAT1 6772
Two-hybrid Homo sapiens
54 PAPOLG  
Two-hybrid Homo sapiens
55 SREBF2 6721
Two-hybrid Homo sapiens
56 MYH6 4624
Affinity Capture-MS Homo sapiens
57 CEBPZ  
Two-hybrid Homo sapiens
58 CHAF1A  
Two-hybrid Homo sapiens
59 ACTN3 89
Affinity Capture-MS Homo sapiens
60 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 GOLGA1  
Co-localization Homo sapiens
62 LGALS7B 653499
Affinity Capture-MS Homo sapiens
63 RAI1 10743
Two-hybrid Homo sapiens
64 MYBL2 4605
Two-hybrid Homo sapiens
65 CAPN2 824
Affinity Capture-MS Homo sapiens
66 EHMT1  
Two-hybrid Homo sapiens
67 KRAS 3845
Proximity Label-MS Homo sapiens
68 ZNF490  
Two-hybrid Homo sapiens
69 KDM2B 84678
Two-hybrid Homo sapiens
70 KBTBD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 LZTR1 8216
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 SCMH1  
Two-hybrid Homo sapiens
73 TRIM72  
Affinity Capture-MS Homo sapiens
74 MYH7 4625
Affinity Capture-MS Homo sapiens
75 ATP2A3 489
Affinity Capture-MS Homo sapiens
76 FANK1  
Two-hybrid Homo sapiens
77 ZNF451 26036
Two-hybrid Homo sapiens
78 TBX2  
Two-hybrid Homo sapiens
79 PNMA6A  
Affinity Capture-MS Homo sapiens
80 DNAJC6  
Affinity Capture-MS Homo sapiens
81 HRAS 3265
Reconstituted Complex Homo sapiens
82 HCLS1 3059
Two-hybrid Homo sapiens
83 SP100 6672
Two-hybrid Homo sapiens
84 MYH4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LZTR1 is involved
No pathways found





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