Gene description for LGALS7B
Gene name lectin, galactoside-binding, soluble, 7B
Gene symbol LGALS7B
Other names/aliases GAL7
Gal-7
HKL-14
LGALS7
PI7
Species Homo sapiens
 Database cross references - LGALS7B
ExoCarta ExoCarta_653499
Vesiclepedia VP_653499
Entrez Gene 653499
HGNC 34447
UniProt P47929  
 LGALS7B identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Saliva 19199708    
Thymus 23844026    
 Gene ontology annotations for LGALS7B
Molecular Function
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IBA
Biological Process
    apoptotic process GO:0006915 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 TAS
Subcellular Localization
    extracellular space GO:0005615 TAS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified LGALS7B in exosomes
1
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
4
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LGALS7B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBA3C 7278
Affinity Capture-MS Homo sapiens
2 FNDC5  
Affinity Capture-MS Homo sapiens
3 FNDC1 84624
Affinity Capture-MS Homo sapiens
4 SSBP2  
Affinity Capture-MS Homo sapiens
5 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KLHL8  
Affinity Capture-MS Homo sapiens
7 DPYSL5  
Affinity Capture-MS Homo sapiens
8 IFNA4  
Affinity Capture-MS Homo sapiens
9 RHBDD1 84236
Affinity Capture-MS Homo sapiens
10 ADH1C 126
Affinity Capture-MS Homo sapiens
11 LZTR1 8216
Affinity Capture-MS Homo sapiens
12 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
13 AGPAT1 10554
Affinity Capture-MS Homo sapiens
14 SLC25A6 293
Affinity Capture-MS Homo sapiens
15 C18orf21  
Affinity Capture-MS Homo sapiens
16 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
17 HSPA6 3310
Two-hybrid Homo sapiens
18 PIGT 51604
Affinity Capture-MS Homo sapiens
19 CCNC  
Affinity Capture-MS Homo sapiens
20 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GAB1  
Affinity Capture-MS Homo sapiens
23 NRSN1  
Affinity Capture-MS Homo sapiens
24 MKS1 54903
Affinity Capture-MS Homo sapiens
25 POLE2  
Affinity Capture-MS Homo sapiens
26 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ADSS 159
Affinity Capture-MS Homo sapiens
28 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 VPS13B  
Affinity Capture-MS Homo sapiens
30 MTPAP 55149
Affinity Capture-MS Homo sapiens
31 TUBB8 347688
Affinity Capture-MS Homo sapiens
32 VWA9  
Affinity Capture-MS Homo sapiens
33 ZSCAN12  
Affinity Capture-MS Homo sapiens
34 LSM2 57819
Two-hybrid Homo sapiens
35 METTL6  
Affinity Capture-MS Homo sapiens
36 CDK15  
Affinity Capture-MS Homo sapiens
37 C1orf35  
Affinity Capture-MS Homo sapiens
38 ZC3HC1  
Affinity Capture-MS Homo sapiens
39 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
40 ELAC2 60528
Affinity Capture-MS Homo sapiens
41 PTDSS1 9791
Affinity Capture-MS Homo sapiens
42 ZDHHC19  
Affinity Capture-MS Homo sapiens
43 FUNDC2 65991
Affinity Capture-MS Homo sapiens
44 LGALS7 3963
Affinity Capture-MS Homo sapiens
45 EIF2B5 8893
Affinity Capture-MS Homo sapiens
46 CERS3  
Affinity Capture-MS Homo sapiens
47 SSBP1 6742
Two-hybrid Homo sapiens
48 KLHL11  
Affinity Capture-MS Homo sapiens
49 PKN2 5586
Affinity Capture-MS Homo sapiens
50 RNF115  
Affinity Capture-MS Homo sapiens
51 POLA2  
Affinity Capture-MS Homo sapiens
52 USP4 7375
Affinity Capture-MS Homo sapiens
53 E2F6 1876
Affinity Capture-MS Homo sapiens
54 ERCC3  
Affinity Capture-MS Homo sapiens
55 DPYSL2 1808
Affinity Capture-MS Homo sapiens
56 MBNL1 4154
Affinity Capture-MS Homo sapiens
57 OPN5  
Affinity Capture-MS Homo sapiens
58 DPYSL4 10570
Affinity Capture-MS Homo sapiens
59 GDF5 8200
Affinity Capture-MS Homo sapiens
60 BPHL 670
Affinity Capture-MS Homo sapiens
61 SARAF  
Affinity Capture-MS Homo sapiens
62 TGM5  
Two-hybrid Homo sapiens
63 PINK1  
Affinity Capture-MS Homo sapiens
64 GOT1 2805
Affinity Capture-MS Homo sapiens
65 COPS5 10987
Affinity Capture-MS Homo sapiens
66 SSUH2  
Affinity Capture-MS Homo sapiens
67 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 FAIM2  
Affinity Capture-MS Homo sapiens
69 B3GNT2 10678
Affinity Capture-MS Homo sapiens
70 OR2A4 79541
Affinity Capture-MS Homo sapiens
71 HCN1  
Affinity Capture-MS Homo sapiens
72 UPK1A 11045
Affinity Capture-MS Homo sapiens
73 NAMPT 10135
Affinity Capture-MS Homo sapiens
74 SLC37A4 2542
Affinity Capture-MS Homo sapiens
75 CCR1  
Affinity Capture-MS Homo sapiens
76 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
77 GUCY1A3  
Affinity Capture-MS Homo sapiens
78 STX17 55014
Affinity Capture-MS Homo sapiens
79 RIPPLY3  
Affinity Capture-MS Homo sapiens
80 PIK3C3 5289
Affinity Capture-MS Homo sapiens
81 DKK2  
Affinity Capture-MS Homo sapiens
82 TUBA1B 10376
Affinity Capture-MS Homo sapiens
83 PHF11 51131
Affinity Capture-MS Homo sapiens
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