Gene description for BPHL
Gene name biphenyl hydrolase-like (serine hydrolase)
Gene symbol BPHL
Other names/aliases BPH-RP
MCNAA
VACVASE
Species Homo sapiens
 Database cross references - BPHL
ExoCarta ExoCarta_670
Vesiclepedia VP_670
Entrez Gene 670
HGNC 1094
MIM 603156
UniProt Q86WA6   Q86W56  
 BPHL identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BPHL
Molecular Function
    protein binding GO:0005515 IPI
    alpha-amino-acid esterase activity GO:0047658 IDA
    alpha-amino-acid esterase activity GO:0047658 TAS
Biological Process
    amino acid metabolic process GO:0006520 TAS
    xenobiotic metabolic process GO:0006805 TAS
    response to toxic substance GO:0009636 TAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 ISS
    mitochondrial outer membrane GO:0005741 TAS
 Experiment description of studies that identified BPHL in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BPHL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERPINB3 6317
Affinity Capture-MS Homo sapiens
2 IVL 3713
Affinity Capture-MS Homo sapiens
3 MACROD1 28992
Co-fractionation Homo sapiens
4 LRP4 4038
Co-fractionation Homo sapiens
5 IL36G 56300
Affinity Capture-MS Homo sapiens
6 RP2 6102
Affinity Capture-MS Homo sapiens
7 PLA2G4D  
Affinity Capture-MS Homo sapiens
8 POF1B 79983
Affinity Capture-MS Homo sapiens
9 PPP5C 5536
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TXNRD1 7296
Co-fractionation Homo sapiens
11 TREX2  
Affinity Capture-MS Homo sapiens
12 MUT 4594
Affinity Capture-MS Homo sapiens
13 DUT 1854
Co-fractionation Homo sapiens
14 S100A7A 338324
Affinity Capture-MS Homo sapiens
15 SHMT2 6472
Affinity Capture-RNA Homo sapiens
16 ALOX12B  
Affinity Capture-MS Homo sapiens
17 HAL 3034
Affinity Capture-MS Homo sapiens
18 CARS2 79587
Co-fractionation Homo sapiens
19 APEX1 328
Affinity Capture-RNA Homo sapiens
20 PPL 5493
Affinity Capture-MS Homo sapiens
21 TTC19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GSDMA 284110
Affinity Capture-MS Homo sapiens
23 TST 7263
Co-fractionation Homo sapiens
24 TGM3 7053
Affinity Capture-MS Homo sapiens
25 CALML5 51806
Affinity Capture-MS Homo sapiens
26 PRKCA 5578
Affinity Capture-MS Homo sapiens
27 SERPINB4 6318
Affinity Capture-MS Homo sapiens
28 CENPM  
Affinity Capture-MS Homo sapiens
29 LGALS7B 653499
Affinity Capture-MS Homo sapiens
30 ESRRG  
Two-hybrid Homo sapiens
31 EVPL 2125
Affinity Capture-MS Homo sapiens
32 NCCRP1 342897
Affinity Capture-MS Homo sapiens
33 ALDH3A1 218
Affinity Capture-MS Homo sapiens
34 GLUL 2752
Affinity Capture-MS Homo sapiens
35 HSPD1 3329
Affinity Capture-MS Homo sapiens
36 SULT2B1 6820
Affinity Capture-MS Homo sapiens
37 SETD3 84193
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TIMM13 26517
Co-fractionation Homo sapiens
39 TOMM20 9804
Affinity Capture-MS Homo sapiens
40 MTHFD1L 25902
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which BPHL is involved
No pathways found





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