Gene description for MTHFD1L
Gene name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Gene symbol MTHFD1L
Other names/aliases FTHFSDC1
MTC1THFS
dJ292B18.2
Species Homo sapiens
 Database cross references - MTHFD1L
ExoCarta ExoCarta_25902
Entrez Gene 25902
HGNC 21055
MIM 611427
UniProt Q6UB35  
 MTHFD1L identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MTHFD1L
Molecular Function
    formate-tetrahydrofolate ligase activity GO:0004329 IDA
    protein homodimerization activity GO:0042803 IDA
    methenyltetrahydrofolate cyclohydrolase activity GO:0004477 IBA
    methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 IBA
    ATP binding GO:0005524 IDA
Biological Process
    tetrahydrofolate metabolic process GO:0046653 IDA
    oxidation-reduction process GO:0055114 IEA
    one-carbon metabolic process GO:0006730 IBA
    tetrahydrofolate interconversion GO:0035999 IEA
    folic acid-containing compound metabolic process GO:0006760 IDA
    formate metabolic process GO:0015942 IDA
    folic acid-containing compound biosynthetic process GO:0009396 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    membrane GO:0016020 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified MTHFD1L in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MTHFD1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CASP4  
Affinity Capture-MS Homo sapiens
2 MAGED1  
Affinity Capture-MS Homo sapiens
3 WDR8  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MTHFD1L is involved
No pathways found





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