Gene description for CLPP
Gene name caseinolytic mitochondrial matrix peptidase proteolytic subunit
Gene symbol CLPP
Other names/aliases DFNB81
PRLTS3
Species Homo sapiens
 Database cross references - CLPP
ExoCarta ExoCarta_8192
Vesiclepedia VP_8192
Entrez Gene 8192
HGNC 2084
MIM 601119
UniProt Q16740  
 CLPP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CLPP
Molecular Function
    endopeptidase activity GO:0004175 IDA
    ATP-dependent peptidase activity GO:0004176 IBA
    ATP-dependent peptidase activity GO:0004176 TAS
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IDA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 TAS
    identical protein binding GO:0042802 IEA
    ATPase binding GO:0051117 IBA
Biological Process
    proteolysis GO:0006508 IDA
    protein quality control for misfolded or incompletely synthesized proteins GO:0006515 IBA
    membrane protein proteolysis GO:0033619 IDA
    mitochondrial protein catabolic process GO:0035694 TAS
    proteolysis involved in protein catabolic process GO:0051603 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 NAS
    mitochondrial matrix GO:0005759 TAS
    endopeptidase Clp complex GO:0009368 IBA
    endopeptidase Clp complex GO:0009368 IDA
    endopeptidase Clp complex GO:0009368 IPI
 Experiment description of studies that identified CLPP in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CLPP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPST 4357
Proximity Label-MS Homo sapiens
2 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
3 OXCT1 5019
Proximity Label-MS Homo sapiens
4 DNAJC11 55735
Proximity Label-MS Homo sapiens
5 STT3A 3703
Proximity Label-MS Homo sapiens
6 RBPMS 11030
Two-hybrid Homo sapiens
7 SHC1 6464
Proximity Label-MS Homo sapiens
8 SPRED2 200734
Affinity Capture-MS Homo sapiens
9 LDHB 3945
Co-fractionation Homo sapiens
10 ACOT9 23597
Proximity Label-MS Homo sapiens
11 ALG12  
Proximity Label-MS Homo sapiens
12 VMP1 81671
Proximity Label-MS Homo sapiens
13 MTG2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
14 SLC2A1 6513
Proximity Label-MS Homo sapiens
15 MRPL24  
Proximity Label-MS Homo sapiens
16 SUPV3L1 6832
Proximity Label-MS Homo sapiens
17 LPCAT1 79888
Proximity Label-MS Homo sapiens
18 QSOX2 169714
Proximity Label-MS Homo sapiens
19 ATPAF2 91647
Proximity Label-MS Homo sapiens
20 DUT 1854
Proximity Label-MS Homo sapiens
21 DPM1 8813
Proximity Label-MS Homo sapiens
22 LPGAT1 9926
Proximity Label-MS Homo sapiens
23 IARS2 55699
Proximity Label-MS Homo sapiens
24 SRC 6714
Proximity Label-MS Homo sapiens
25 THTPA  
Proximity Label-MS Homo sapiens
26 ETFA 2108
Proximity Label-MS Homo sapiens
27 POLRMT 5442
Proximity Label-MS Homo sapiens
28 HERC2 8924
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
29 EPT1 85465
Proximity Label-MS Homo sapiens
30 NDUFAB1 4706
Proximity Label-MS Homo sapiens
31 SLC30A9 10463
Proximity Label-MS Homo sapiens
32 BCS1L 617
Proximity Label-MS Homo sapiens
33 PREPL 9581
Proximity Label-MS Homo sapiens
34 NUDT16L1 84309
Proximity Label-MS Homo sapiens
35 VWA8 23078
Proximity Label-MS Homo sapiens
36 GNPAT 8443
Proximity Label-MS Homo sapiens
37 MRPL47 57129
Proximity Label-MS Homo sapiens
38 MLEC 9761
Proximity Label-MS Homo sapiens
39 TMEM87A 25963
Proximity Label-MS Homo sapiens
40 ZADH2 284273
Proximity Label-MS Homo sapiens
41 AP3M1 26985
Proximity Label-MS Homo sapiens
42 DLAT 1737
Proximity Label-MS Homo sapiens
43 MTCH2 23788
Proximity Label-MS Homo sapiens
44 PELO 53918
Proximity Label-MS Homo sapiens
45 ACADVL 37
Proximity Label-MS Homo sapiens
46 NT5DC2 64943
Proximity Label-MS Homo sapiens
47 ILVBL 10994
Proximity Label-MS Homo sapiens
48 TUFM 7284
Proximity Label-MS Homo sapiens
49 UBAC2 337867
Proximity Label-MS Homo sapiens
50 PIN1 5300
Proximity Label-MS Homo sapiens
51 COX8A  
Proximity Label-MS Homo sapiens
52 PIGT 51604
Proximity Label-MS Homo sapiens
53 MRPS6  
Proximity Label-MS Homo sapiens
54 ACADM 34
Proximity Label-MS Homo sapiens
55 THG1L 54974
Proximity Label-MS Homo sapiens
56 USMG5 84833
Proximity Label-MS Homo sapiens
57 PIGS 94005
Proximity Label-MS Homo sapiens
58 DBT 1629
Proximity Label-MS Homo sapiens
59 MTRF1L  
Proximity Label-MS Homo sapiens
60 SEC61B 10952
Proximity Label-MS Homo sapiens
61 ACN9  
Proximity Label-MS Homo sapiens
62 MRPL41 64975
Proximity Label-MS Homo sapiens
63 ATP9A 10079
Proximity Label-MS Homo sapiens
64 CDS2 8760
Proximity Label-MS Homo sapiens
65 RAB6A 5870
Proximity Label-MS Homo sapiens
66 RARS2  
Proximity Label-MS Homo sapiens
67 EARS2  
Proximity Label-MS Homo sapiens
68 WBSCR16  
Affinity Capture-MS Homo sapiens
69 HADHA 3030
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
70 MRPS12  
Proximity Label-MS Homo sapiens
71 MTIF2 4528
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
72 NDUFA13 51079
Proximity Label-MS Homo sapiens
73 NOA1  
Proximity Label-MS Homo sapiens
74 SDHA 6389
Proximity Label-MS Homo sapiens
75 TMEM223  
Proximity Label-MS Homo sapiens
76 ASS1 445
Proximity Label-MS Homo sapiens
77 SYT6  
Affinity Capture-MS Homo sapiens
78 AAAS 8086
Proximity Label-MS Homo sapiens
79 VARS2  
Proximity Label-MS Homo sapiens
80 DHX37  
Proximity Label-MS Homo sapiens
81 ANP32E 81611
Proximity Label-MS Homo sapiens
82 POLDIP2 26073
Proximity Label-MS Homo sapiens
83 TBP  
Proximity Label-MS Homo sapiens
84 TMEM173  
Affinity Capture-MS Homo sapiens
85 GNAS 2778
Proximity Label-MS Homo sapiens
86 RPA3 6119
Proximity Label-MS Homo sapiens
87 WRB 7485
Proximity Label-MS Homo sapiens
88 COX6C 1345
Proximity Label-MS Homo sapiens
89 DHRS7B 25979
Proximity Label-MS Homo sapiens
90 DLST 1743
Proximity Label-MS Homo sapiens
91 TSFM 10102
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
92 GSTK1 373156
Proximity Label-MS Homo sapiens
93 DAP3 7818
Proximity Label-MS Homo sapiens
94 LMF2 91289
Proximity Label-MS Homo sapiens
95 NCLN 56926
Proximity Label-MS Homo sapiens
96 HSPA4 3308
Co-fractionation Homo sapiens
97 NDUFA10 4705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
98 PARL  
Proximity Label-MS Homo sapiens
99 P4HA3 283208
Two-hybrid Homo sapiens
100 MARS2 92935
Proximity Label-MS Homo sapiens
101 SLC37A4 2542
Proximity Label-MS Homo sapiens
102 NADK2 133686
Proximity Label-MS Homo sapiens
103 GBAS 2631
Proximity Label-MS Homo sapiens
104 HSPE1 3336
Proximity Label-MS Homo sapiens
105 GLS 2744
Proximity Label-MS Homo sapiens
106 PDK3 5165
Proximity Label-MS Homo sapiens
107 AUH 549
Proximity Label-MS Homo sapiens
108 IDH3B 3420
Proximity Label-MS Homo sapiens
109 SUCLG2 8801
Proximity Label-MS Homo sapiens
110 LARS2 23395
Proximity Label-MS Homo sapiens
111 C7orf55  
Proximity Label-MS Homo sapiens
112 UQCC1 55245
Affinity Capture-MS Homo sapiens
113 COX5A 9377
Proximity Label-MS Homo sapiens
114 NGEF  
Affinity Capture-MS Homo sapiens
115 YARS 8565
Proximity Label-MS Homo sapiens
116 SLC25A15  
Proximity Label-MS Homo sapiens
117 TRUB1 142940
Proximity Label-MS Homo sapiens
118 PTDSS1 9791
Proximity Label-MS Homo sapiens
119 NUDT19 390916
Proximity Label-MS Homo sapiens
120 SSBP1 6742
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
121 OAT 4942
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
122 ALG6  
Proximity Label-MS Homo sapiens
123 NDUFAF3 25915
Proximity Label-MS Homo sapiens
124 NME4 4833
Proximity Label-MS Homo sapiens
125 NDC1 55706
Proximity Label-MS Homo sapiens
126 HNRNPLL 92906
Proximity Label-MS Homo sapiens
127 ACOT1 641371
Proximity Label-MS Homo sapiens
128 ITPA 3704
Proximity Label-MS Homo sapiens
129 FECH 2235
Proximity Label-MS Homo sapiens
130 ACO2 50
Proximity Label-MS Homo sapiens
131 HSDL1 83693
Proximity Label-MS Homo sapiens
132 ACSF3 197322
Proximity Label-MS Homo sapiens
133 MRPL55  
Proximity Label-MS Homo sapiens
134 DNAJC10 54431
Proximity Label-MS Homo sapiens
135 POLG  
Proximity Label-MS Homo sapiens
136 MRPL28 10573
Proximity Label-MS Homo sapiens
137 SCAMP3 10067
Proximity Label-MS Homo sapiens
138 NDUFS6  
Proximity Label-MS Homo sapiens
139 CLPTM1 1209
Proximity Label-MS Homo sapiens
140 GNAI3 2773
Proximity Label-MS Homo sapiens
141 SEC61A1 29927
Proximity Label-MS Homo sapiens
142 GLRX5 51218
Proximity Label-MS Homo sapiens
143 CDIPT 10423
Proximity Label-MS Homo sapiens
144 AFG3L2 10939
Proximity Label-MS Homo sapiens
145 PMPCA 23203
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
146 MRPL48  
Proximity Label-MS Homo sapiens
147 FBXO7 25793
Proximity Label-MS Homo sapiens
148 CTBP2 1488
Proximity Label-MS Homo sapiens
149 ARL6IP5 10550
Proximity Label-MS Homo sapiens
150 GTPBP10  
Proximity Label-MS Homo sapiens
151 RPA2 6118
Proximity Label-MS Homo sapiens
152 MTPAP 55149
Proximity Label-MS Homo sapiens
153 ALDH2 217
Proximity Label-MS Homo sapiens
154 SURF4 6836
Proximity Label-MS Homo sapiens
155 NTNG1  
Affinity Capture-MS Homo sapiens
156 GPT2  
Proximity Label-MS Homo sapiens
157 FDXR 2232
Proximity Label-MS Homo sapiens
158 CLUH 23277
Proximity Label-MS Homo sapiens
159 MRPL44  
Proximity Label-MS Homo sapiens
160 NDUFS2 4720
Proximity Label-MS Homo sapiens
161 ATP5L 10632
Proximity Label-MS Homo sapiens
162 OGDH 4967
Proximity Label-MS Homo sapiens
163 GAP43  
Co-fractionation Homo sapiens
164 AK3 50808
Proximity Label-MS Homo sapiens
165 TRMT2B  
Proximity Label-MS Homo sapiens
166 HARS2 23438
Proximity Label-MS Homo sapiens
167 ELOVL1 64834
Proximity Label-MS Homo sapiens
168 FBXO17 115290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 MRPS23 51649
Proximity Label-MS Homo sapiens
170 NDUFA5 4698
Proximity Label-MS Homo sapiens
171 HIBCH 26275
Proximity Label-MS Homo sapiens
172 TMEM97 27346
Proximity Label-MS Homo sapiens
173 ERAL1  
Proximity Label-MS Homo sapiens
174 NDUFV3 4731
Proximity Label-MS Homo sapiens
175 LYRM5  
Proximity Label-MS Homo sapiens
176 PMPCB 9512
Proximity Label-MS Homo sapiens
177 TACO1  
Proximity Label-MS Homo sapiens
178 FASTKD2  
Proximity Label-MS Homo sapiens
179 ARNT2  
Affinity Capture-MS Homo sapiens
180 RHOG 391
Proximity Label-MS Homo sapiens
181 NNT 23530
Proximity Label-MS Homo sapiens
182 SLC25A10 1468
Proximity Label-MS Homo sapiens
183 C6orf203  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
184 ZNF133  
Affinity Capture-MS Homo sapiens
185 MRPL45 84311
Proximity Label-MS Homo sapiens
186 RAB21 23011
Proximity Label-MS Homo sapiens
187 LYN 4067
Proximity Label-MS Homo sapiens
188 ATPAF1  
Proximity Label-MS Homo sapiens
189 TMEM43 79188
Proximity Label-MS Homo sapiens
190 RTN4IP1  
Proximity Label-MS Homo sapiens
191 PDHX 8050
Proximity Label-MS Homo sapiens
192 RAP1A 5906
Proximity Label-MS Homo sapiens
193 RFK 55312
Proximity Label-MS Homo sapiens
194 PPP2CA 5515
Two-hybrid Homo sapiens
195 NDUFA2 4695
Proximity Label-MS Homo sapiens
196 THNSL1 79896
Proximity Label-MS Homo sapiens
197 AARS2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
198 NDUFAF7  
Proximity Label-MS Homo sapiens
199 HSD17B8  
Proximity Label-MS Homo sapiens
200 ABCB7 22
Proximity Label-MS Homo sapiens
201 GTPBP3  
Proximity Label-MS Homo sapiens
202 ALDH7A1 501
Proximity Label-MS Homo sapiens
203 IBA57  
Proximity Label-MS Homo sapiens
204 AIFM1 9131
Proximity Label-MS Homo sapiens
205 MRPS35 60488
Proximity Label-MS Homo sapiens
206 HIGD1A 25994
Proximity Label-MS Homo sapiens
207 MRPS11  
Proximity Label-MS Homo sapiens
208 MTX2 10651
Proximity Label-MS Homo sapiens
209 SLC27A4 10999
Proximity Label-MS Homo sapiens
210 ATP5F1 515
Proximity Label-MS Homo sapiens
211 EGFR 1956
Affinity Capture-MS Homo sapiens
212 HSD17B10 3028
Proximity Label-MS Homo sapiens
213 DHTKD1 55526
Proximity Label-MS Homo sapiens
214 UBLCP1  
Proximity Label-MS Homo sapiens
215 SLC3A2 6520
Proximity Label-MS Homo sapiens
216 C19orf70  
Proximity Label-MS Homo sapiens
217 ACAD9 28976
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
218 DSTN 11034
Proximity Label-MS Homo sapiens
219 RCN2 5955
Co-fractionation Homo sapiens
220 LPCAT3 10162
Proximity Label-MS Homo sapiens
221 NCAPG2 54892
Proximity Label-MS Homo sapiens
222 MRPS17 51373
Proximity Label-MS Homo sapiens
223 NDUFV2 4729
Proximity Label-MS Homo sapiens
224 MCUR1 63933
Proximity Label-MS Homo sapiens
225 PPIF 10105
Proximity Label-MS Homo sapiens
226 AP3S1 1176
Proximity Label-MS Homo sapiens
227 SLC16A1 6566
Proximity Label-MS Homo sapiens
228 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
229 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
230 C17orf80 55028
Proximity Label-MS Homo sapiens
231 NUTF2 10204
Two-hybrid Homo sapiens
232 ALDH4A1 8659
Proximity Label-MS Homo sapiens
233 WARS2  
Proximity Label-MS Homo sapiens
234 ARF5 381
Proximity Label-MS Homo sapiens
235 BCKDHA 593
Proximity Label-MS Homo sapiens
236 ECI2 10455
Proximity Label-MS Homo sapiens
237 GOLPH3 64083
Affinity Capture-MS Homo sapiens
238 PIGU 128869
Proximity Label-MS Homo sapiens
239 TRIM43  
Affinity Capture-MS Homo sapiens
240 SHMT2 6472
Co-fractionation Homo sapiens