Gene description for MRPL28
Gene name mitochondrial ribosomal protein L28
Gene symbol MRPL28
Other names/aliases MAAT1
p15
Species Homo sapiens
 Database cross references - MRPL28
ExoCarta ExoCarta_10573
Entrez Gene 10573
HGNC 14484
MIM 604853
UniProt Q13084  
 MRPL28 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MRPL28
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    structural constituent of ribosome GO:0003735 NAS
Biological Process
    organelle organization GO:0006996 TAS
    mitochondrial translational initiation GO:0070124 TAS
    translation GO:0006412 NAS
    mitochondrial translational elongation GO:0070125 TAS
    mitochondrial translation GO:0032543 TAS
    mitochondrial translational termination GO:0070126 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    cytoplasm GO:0005737 IDA
    mitochondrial ribosome GO:0005761 NAS
    mitochondrion GO:0005739 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified MRPL28 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MRPL28
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBB3 10381
Two-hybrid Homo sapiens
View the network image/svg+xml



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