Gene description for YBX2
Gene name Y box binding protein 2
Gene symbol YBX2
Other names/aliases CONTRIN
CSDA3
DBPC
MSY2
Species Homo sapiens
 Database cross references - YBX2
ExoCarta ExoCarta_51087
Entrez Gene 51087
HGNC 17948
MIM 611447
UniProt Q9Y2T7  
 YBX2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for YBX2
Molecular Function
    chromatin binding GO:0003682 IEA
    translation regulator activity GO:0045182 IEA
    lipid binding GO:0008289 IEA
    mRNA 3'-UTR binding GO:0003730 IEA
    ribonucleoprotein complex binding GO:0043021 IEA
    DNA binding GO:0003677 IEA
Biological Process
    negative regulation of translation GO:0017148 IEA
    negative regulation of binding GO:0051100 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    spermatogenesis GO:0007283 TAS
    oocyte development GO:0048599 IEA
    mRNA stabilization GO:0048255 IEA
    spermatid development GO:0007286 IEA
    translational attenuation GO:0009386 TAS
Subcellular Localization
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 TAS
    polysome GO:0005844 IEA
 Experiment description of studies that identified YBX2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for YBX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which YBX2 is involved
No pathways found





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