Gene description for LARP1
Gene name La ribonucleoprotein domain family, member 1
Gene symbol LARP1
Other names/aliases LARP
Species Homo sapiens
 Database cross references - LARP1
ExoCarta ExoCarta_23367
Entrez Gene 23367
HGNC 29531
MIM 612059
UniProt Q6PKG0  
 LARP1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for LARP1
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    eukaryotic initiation factor 4E binding GO:0008190 IPI
    mRNA 3'-UTR binding GO:0003730 IDA
    translation activator activity GO:0008494 IMP
    protein binding GO:0005515 IPI
    RNA cap binding GO:0000339 IDA
    mRNA 5'-UTR binding GO:0048027 IDA
    translation initiation factor binding GO:0031369 IDA
Biological Process
    TOR signaling GO:0031929 IMP
    positive regulation of macroautophagy GO:0016239 IMP
    cell proliferation GO:0008283 IMP
    positive regulation of translation GO:0045727 IMP
    translational initiation GO:0006413 IMP
Subcellular Localization
    membrane GO:0016020 IDA
    TORC1 complex GO:0031931 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified LARP1 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for LARP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAQ 10971
Affinity Capture-MS Homo sapiens
2 YWHAG 7532
Affinity Capture-MS Homo sapiens
3 YWHAB 7529
Affinity Capture-MS Homo sapiens
4 YWHAZ 7534
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LARP1 is involved
No pathways found





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