Gene description for RB1CC1
Gene name RB1-inducible coiled-coil 1
Gene symbol RB1CC1
Other names/aliases ATG17
Species Homo sapiens
 Database cross references - RB1CC1
ExoCarta ExoCarta_9821
Entrez Gene 9821
HGNC 15574
MIM 606837
UniProt Q8TDY2  
 RB1CC1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for RB1CC1
Molecular Function
    protein kinase binding GO:0019901 IBA
    protein binding GO:0005515 IPI
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    autophagosome assembly GO:0000045 IBA
    cell cycle GO:0007049 IEA
    positive regulation of protein phosphorylation GO:0001934 IBA
    JNK cascade GO:0007254 IEA
    positive regulation of cell size GO:0045793 IEA
    regulation of autophagy GO:0010506 ISS
    heart development GO:0007507 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA
    liver development GO:0001889 IEA
Subcellular Localization
    nuclear membrane GO:0031965 IDA
    ULK1-ATG13-FIP200 complex GO:0070969 IPI
    cytoplasm GO:0005737 IDA
    pre-autophagosomal structure membrane GO:0034045 ISS
    cytosol GO:0005829 IEA
    ATG1/UKL1 signaling complex GO:0034273 IBA
 Experiment description of studies that identified RB1CC1 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for RB1CC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTK2B 2185
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 MAP3K5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 DBNL 28988
Affinity Capture-MS Homo sapiens
4 PREI3  
Affinity Capture-MS Homo sapiens
5 TRAF2  
Affinity Capture-Western Homo sapiens
6 CDK19  
Affinity Capture-MS Homo sapiens
7 PTK2 5747
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
8 FLJ20105  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RB1CC1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here