Gene description for TACC1
Gene name transforming, acidic coiled-coil containing protein 1
Gene symbol TACC1
Other names/aliases Ga55
Species Homo sapiens
 Database cross references - TACC1
ExoCarta ExoCarta_6867
Entrez Gene 6867
HGNC 11522
MIM 605301
UniProt O75410  
 TACC1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for TACC1
Molecular Function
    protein domain specific binding GO:0019904 IEA
    protein binding GO:0005515 IPI
Biological Process
    cell proliferation GO:0008283 IBA
    regulation of microtubule-based process GO:0032886 IEA
    cerebral cortex development GO:0021987 IBA
    cell cycle GO:0007049 IEA
    cell division GO:0051301 IEA
    microtubule cytoskeleton organization GO:0000226 IBA
    neurogenesis GO:0022008 IEA
    interkinetic nuclear migration GO:0022027 IEA
Subcellular Localization
    microtubule organizing center GO:0005815 IEA
    microtubule cytoskeleton GO:0015630 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified TACC1 in exosomes
1
Experiment ID 234
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TACC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AURKB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 YEATS4  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 TDRD7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 LSM7  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 SNRPG 6637
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 STK6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 CKAP5 9793
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TACC1 is involved
No pathways found





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