Gene description for ATP2A1
Gene name ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Gene symbol ATP2A1
Other names/aliases ATP2A
SERCA1
Species Homo sapiens
 Database cross references - ATP2A1
ExoCarta ExoCarta_487
Vesiclepedia VP_487
Entrez Gene 487
HGNC 811
MIM 108730
UniProt O14983  
 ATP2A1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ATP2A1
Molecular Function
    P-type calcium transporter activity GO:0005388 IBA
    P-type calcium transporter activity GO:0005388 IDA
    P-type calcium transporter activity GO:0005388 ISS
    P-type calcium transporter activity GO:0005388 TAS
    calcium ion binding GO:0005509 IMP
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISS
    ATP hydrolysis activity GO:0016887 IEA
    calcium-dependent ATPase activity GO:0030899 ISS
    protein homodimerization activity GO:0042803 IPI
Biological Process
    calcium ion transport GO:0006816 IDA
    calcium ion transport GO:0006816 IMP
    intracellular calcium ion homeostasis GO:0006874 IBA
    regulation of striated muscle contraction GO:0006942 IMP
    apoptotic mitochondrial changes GO:0008637 IMP
    positive regulation of fast-twitch skeletal muscle fiber contraction GO:0031448 IDA
    positive regulation of endoplasmic reticulum calcium ion concentration GO:0032470 IMP
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IMP
    monoatomic ion transmembrane transport GO:0034220 TAS
    response to endoplasmic reticulum stress GO:0034976 IMP
    negative regulation of striated muscle contraction GO:0045988 IMP
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IMP
    maintenance of mitochondrion location GO:0051659 IMP
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IMP
    calcium ion import GO:0070509 IMP
    calcium ion transmembrane transport GO:0070588 IBA
    calcium ion transmembrane transport GO:0070588 IEA
    relaxation of skeletal muscle GO:0090076 IDA
    positive regulation of cardiac muscle cell contraction GO:0106134 ISS
    positive regulation of ATPase-coupled calcium transmembrane transporter activity GO:1901896 ISS
    positive regulation of calcium ion import into sarcoplasmic reticulum GO:1902082 ISS
    regulation of cardiac conduction GO:1903779 TAS
    calcium ion import into sarcoplasmic reticulum GO:1990036 ISS
Subcellular Localization
    mitochondrion GO:0005739 IEA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISS
    membrane GO:0016020 IBA
    membrane GO:0016020 ISS
    membrane GO:0016020 NAS
    sarcoplasmic reticulum GO:0016529 ISS
    sarcoplasmic reticulum GO:0016529 NAS
    platelet dense tubular network membrane GO:0031095 TAS
    H zone GO:0031673 IDA
    I band GO:0031674 IDA
    sarcoplasmic reticulum membrane GO:0033017 IC
    sarcoplasmic reticulum membrane GO:0033017 ISS
    sarcoplasmic reticulum membrane GO:0033017 TAS
    calcium channel complex GO:0034704 IC
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified ATP2A1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATP2A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 ARHGAP1 392
Proximity Label-MS Homo sapiens
4 SRPRB 58477
Proximity Label-MS Homo sapiens
5 JPH1 56704
Proximity Label-MS Homo sapiens
6 VMP1 81671
Proximity Label-MS Homo sapiens
7 KIF20A 10112
Affinity Capture-MS Homo sapiens
8 LPCAT1 79888
Proximity Label-MS Homo sapiens
9 TBL2 26608
Proximity Label-MS Homo sapiens
10 RINT1 60561
Proximity Label-MS Homo sapiens
11 TMEM41B 440026
Proximity Label-MS Homo sapiens
12 AP2A1 160
Proximity Label-MS Homo sapiens
13 SMPD4 55627
Proximity Label-MS Homo sapiens
14 ABCD3 5825
Affinity Capture-MS Homo sapiens
15 ARMCX3 51566
Affinity Capture-MS Homo sapiens
16 TMEM201 199953
Proximity Label-MS Homo sapiens
17 SCARB1 949
Proximity Label-MS Homo sapiens
18 USP33  
Proximity Label-MS Homo sapiens
19 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
20 BET1 10282
Proximity Label-MS Homo sapiens
21 SLC6A15 55117
Proximity Label-MS Homo sapiens
22 TFRC 7037
Proximity Label-MS Homo sapiens
23 CLDND1 56650
Affinity Capture-MS Homo sapiens
24 KIF14 9928
Affinity Capture-MS Homo sapiens
25 NOTCH2 4853
Proximity Label-MS Homo sapiens
26 CAMLG 819
Proximity Label-MS Homo sapiens
27 GOLIM4 27333
Affinity Capture-MS Homo sapiens
28 NOMO1 23420
Affinity Capture-MS Homo sapiens
29 SENP2 59343
Proximity Label-MS Homo sapiens
30 KRT39  
Affinity Capture-MS Homo sapiens
31 USP11 8237
Affinity Capture-MS Homo sapiens
32 TMX1 81542
Proximity Label-MS Homo sapiens
33 GGT7 2686
Proximity Label-MS Homo sapiens
34 SUPT5H 6829
Proximity Label-MS Homo sapiens
35 UGT8  
Proximity Label-MS Homo sapiens
36 TLCD1  
Affinity Capture-MS Homo sapiens
37 CERS2 29956
Proximity Label-MS Homo sapiens
38 FAM162A 26355
Affinity Capture-MS Homo sapiens
39 UBAC2 337867
Proximity Label-MS Homo sapiens
40 UBXN8  
Proximity Label-MS Homo sapiens
41 CLCC1 23155
Proximity Label-MS Homo sapiens
42 ST6GAL1 6480
Affinity Capture-MS Homo sapiens
43 SAR1B 51128
Proximity Label-MS Homo sapiens
44 GORASP2 26003
Proximity Label-MS Homo sapiens
45 FRAS1 80144
Proximity Label-MS Homo sapiens
46 CYC1 1537
Affinity Capture-MS Homo sapiens
47 GRAMD4 23151
Proximity Label-MS Homo sapiens
48 MICU1 10367
Affinity Capture-MS Homo sapiens
49 SEC61B 10952
Proximity Label-MS Homo sapiens
50 REEP5 7905
Proximity Label-MS Homo sapiens
51 ROGDI 79641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TMPO 7112
Proximity Label-MS Homo sapiens
53 ANO6 196527
Proximity Label-MS Homo sapiens
54 HADHB 3032
Affinity Capture-MS Homo sapiens
55 AGPAT1 10554
Proximity Label-MS Homo sapiens
56 LRRC59 55379
Proximity Label-MS Homo sapiens
57 TAPT1 202018
Proximity Label-MS Homo sapiens
58 BCAP31 10134
Proximity Label-MS Homo sapiens
59 TMEM199  
Proximity Label-MS Homo sapiens
60 CUL3 8452
Affinity Capture-MS Homo sapiens
61 GPD2 2820
Affinity Capture-MS Homo sapiens
62 FKBP8 23770
Proximity Label-MS Homo sapiens
63 GLB1L2  
Affinity Capture-MS Homo sapiens
64 MIA3 375056
Proximity Label-MS Homo sapiens
65 WLS 79971
Proximity Label-MS Homo sapiens
66 SNX19  
Proximity Label-MS Homo sapiens
67 ZW10 9183
Proximity Label-MS Homo sapiens
68 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
69 TMCO1 54499
Proximity Label-MS Homo sapiens
70 DLST 1743
Affinity Capture-MS Homo sapiens
71 ABCC1 4363
Proximity Label-MS Homo sapiens
72 FAR2  
Affinity Capture-MS Homo sapiens
73 APBB1  
Proximity Label-MS Homo sapiens
74 SLC30A7 148867
Proximity Label-MS Homo sapiens
75 ENTPD2 954
Affinity Capture-MS Homo sapiens
76 NDUFA3  
Affinity Capture-MS Homo sapiens
77 TMX2 51075
Proximity Label-MS Homo sapiens
78 SLC4A2 6522
Proximity Label-MS Homo sapiens
79 FLVCR1 28982
Proximity Label-MS Homo sapiens
80 HMGCR  
Proximity Label-MS Homo sapiens
81 TMEM57  
Proximity Label-MS Homo sapiens
82 AGPAT9  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 PIEZO1 9780
Affinity Capture-MS Homo sapiens
84 ZFYVE27 118813
Proximity Label-MS Homo sapiens
85 WWOX 51741
Affinity Capture-MS Homo sapiens
86 LRRCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 EMC7 56851
Proximity Label-MS Homo sapiens
88 CLPTM1 1209
Proximity Label-MS Homo sapiens
89 PTPN2 5771
Proximity Label-MS Homo sapiens
90 ITPR3 3710
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
91 LATS1  
Affinity Capture-MS Homo sapiens
92 RABL3 285282
Proximity Label-MS Homo sapiens
93 HACD2 201562
Affinity Capture-MS Homo sapiens
94 ALG10  
Affinity Capture-MS Homo sapiens
95 HM13 81502
Proximity Label-MS Homo sapiens
96 NDC1 55706
Proximity Label-MS Homo sapiens
97 ITPR1 3708
Proximity Label-MS Homo sapiens
98 EI24  
Proximity Label-MS Homo sapiens
99 CISD2 493856
Proximity Label-MS Homo sapiens
100 WFS1 7466
Proximity Label-MS Homo sapiens
101 PRAF2 11230
Proximity Label-MS Homo sapiens
102 VANGL1 81839
Proximity Label-MS Homo sapiens
103 BRI3BP 140707
Proximity Label-MS Homo sapiens
104 C2CD2L 9854
Proximity Label-MS Homo sapiens
105 DDHD2 23259
Proximity Label-MS Homo sapiens
106 SPRTN  
Affinity Capture-MS Homo sapiens
107 ATL1 51062
Proximity Label-MS Homo sapiens
108 TMEM143  
Affinity Capture-MS Homo sapiens
109 DHRS7 51635
Proximity Label-MS Homo sapiens
110 GJA1 2697
Proximity Label-MS Homo sapiens
111 ARL6IP5 10550
Proximity Label-MS Homo sapiens
112 ARFGAP2 84364
Proximity Label-MS Homo sapiens
113 SPTLC1 10558
Proximity Label-MS Homo sapiens
114 GOSR2 9570
Proximity Label-MS Homo sapiens
115 COPA 1314
Proximity Label-MS Homo sapiens
116 SETDB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 ANO8  
Proximity Label-MS Homo sapiens
118 SPG7  
Affinity Capture-MS Homo sapiens
119 ABCD1 215
Affinity Capture-MS Homo sapiens
120 VANGL2  
Proximity Label-MS Homo sapiens
121 WDR41  
Proximity Label-MS Homo sapiens
122 CYB5B 80777
Proximity Label-MS Homo sapiens
123 DDX24 57062
Proximity Label-MS Homo sapiens
124 ELOVL2  
Proximity Label-MS Homo sapiens
125 ATP2A3 489
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
126 TMX3 54495
Proximity Label-MS Homo sapiens
127 TMEM97 27346
Affinity Capture-MS Homo sapiens
128 VCAM1 7412
Affinity Capture-MS Homo sapiens
129 SCD5  
Proximity Label-MS Homo sapiens
130 LMAN1 3998
Proximity Label-MS Homo sapiens
131 KIAA1715 80856
Proximity Label-MS Homo sapiens
132 CHMP7 91782
Proximity Label-MS Homo sapiens
133 HS2ST1 9653
Affinity Capture-MS Homo sapiens
134 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
135 STOM 2040
Proximity Label-MS Homo sapiens
136 C3orf33  
Affinity Capture-MS Homo sapiens
137 SNAP47 116841
Proximity Label-MS Homo sapiens
138 CDKAL1  
Proximity Label-MS Homo sapiens
139 YIF1A 10897
Proximity Label-MS Homo sapiens
140 NPTN 27020
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
141 SLC9A1 6548
Proximity Label-MS Homo sapiens
142 TRPM7 54822
Proximity Label-MS Homo sapiens
143 LHX3  
Affinity Capture-MS Homo sapiens
144 SLC25A17 10478
Affinity Capture-MS Homo sapiens
145 PREB 10113
Proximity Label-MS Homo sapiens
146 STX5 6811
Proximity Label-MS Homo sapiens
147 MRAP2  
Affinity Capture-MS Homo sapiens
148 ANO10 55129
Proximity Label-MS Homo sapiens
149 PLN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
150 SGPL1 8879
Proximity Label-MS Homo sapiens
151 CANX 821
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
152 ESYT1 23344
Proximity Label-MS Homo sapiens
153 EMC8 10328
Proximity Label-MS Homo sapiens
154 XPO1 7514
Proximity Label-MS Homo sapiens
155 ADCY9 115
Proximity Label-MS Homo sapiens
156 SLC27A4 10999
Proximity Label-MS Homo sapiens
157 ABHD12 26090
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 GCNT2 2651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 SEC24A 10802
Proximity Label-MS Homo sapiens
160 RFT1 91869
Proximity Label-MS Homo sapiens
161 FAM134B 54463
Proximity Label-MS Homo sapiens
162 VRK2 7444
Proximity Label-MS Homo sapiens
163 DDRGK1 65992
Proximity Label-MS Homo sapiens
164 MECOM 2122
Affinity Capture-MS Homo sapiens
165 TMEM209 84928
Proximity Label-MS Homo sapiens
166 VIMP 55829
Proximity Label-MS Homo sapiens
167 LEMD3  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 OSBPL8 114882
Proximity Label-MS Homo sapiens
169 CCR8  
Two-hybrid Homo sapiens
170 SUN1 23353
Proximity Label-MS Homo sapiens
171 PLXNB2 23654
Proximity Label-MS Homo sapiens
172 PEX16 9409
Affinity Capture-MS Homo sapiens
173 SLC38A2 54407
Proximity Label-MS Homo sapiens
174 TRIM13  
Proximity Label-MS Homo sapiens
175 ABCB8 11194
Affinity Capture-MS Homo sapiens
176 HMGB1 3146
Affinity Capture-MS Homo sapiens
177 PGRMC1 10857
Proximity Label-MS Homo sapiens
178 C5orf24 134553
Affinity Capture-MS Homo sapiens
179 TMEM214 54867
Proximity Label-MS Homo sapiens
180 NSDHL 50814
Proximity Label-MS Homo sapiens
181 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
182 MMGT1 93380
Proximity Label-MS Homo sapiens
183 AUP1 550
Proximity Label-MS Homo sapiens
184 PLD3 23646
Proximity Label-MS Homo sapiens
185 TMEM109 79073
Proximity Label-MS Homo sapiens
186 YKT6 10652
Proximity Label-MS Homo sapiens
187 IGF2R 3482
Proximity Label-MS Homo sapiens
188 GOLM1 51280
Affinity Capture-MS Homo sapiens
189 CKAP4 10970
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 ATOH1  
Affinity Capture-MS Homo sapiens
191 ATP13A1 57130
Proximity Label-MS Homo sapiens
192 RAB23 51715
Proximity Label-MS Homo sapiens
193 HACD3 51495
Proximity Label-MS Homo sapiens
194 CLCN7 1186
Proximity Label-MS Homo sapiens
195 PRKCD 5580
Proximity Label-MS Homo sapiens
196 DHCR24 1718
Proximity Label-MS Homo sapiens
197 TM9SF2 9375
Proximity Label-MS Homo sapiens
198 SYNE2 23224
Proximity Label-MS Homo sapiens
199 PTPN1 5770
Proximity Label-MS Homo sapiens
200 SLN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
201 RTN4 57142
Proximity Label-MS Homo sapiens
202 TEX264 51368
Proximity Label-MS Homo sapiens
203 PTPMT1 114971
Affinity Capture-MS Homo sapiens
204 RAB3B 5865
Proximity Label-MS Homo sapiens
205 DSC2 1824
Proximity Label-MS Homo sapiens
206 NUP210 23225
Proximity Label-MS Homo sapiens
207 LSG1  
Proximity Label-MS Homo sapiens
208 SSR1 6745
Proximity Label-MS Homo sapiens
209 CCDC47 57003
Proximity Label-MS Homo sapiens
210 UTP20 27340
Proximity Label-MS Homo sapiens
211 MXRA7 439921
Proximity Label-MS Homo sapiens
212 MTDH 92140
Proximity Label-MS Homo sapiens
213 ESYT2 57488
Proximity Label-MS Homo sapiens
214 CLGN 1047
Proximity Label-MS Homo sapiens
215 DGAT1 8694
Affinity Capture-MS Homo sapiens
216 GBA2  
Proximity Label-MS Homo sapiens
217 NUP155 9631
Proximity Label-MS Homo sapiens
218 PXMP2  
Affinity Capture-MS Homo sapiens
219 BSG 682
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
220 UBR4 23352
Proximity Label-MS Homo sapiens
221 EIF2AK3  
Proximity Label-MS Homo sapiens
222 SCFD1 23256
Proximity Label-MS Homo sapiens
223 CANT1 124583
Affinity Capture-MS Homo sapiens
224 TSPAN33 340348
Affinity Capture-MS Homo sapiens
225 BNIP1 662
Proximity Label-MS Homo sapiens
226 ITGA6 3655
Proximity Label-MS Homo sapiens
227 EXOG 9941
Affinity Capture-MS Homo sapiens
228 RSPH6A  
Affinity Capture-MS Homo sapiens