Gene description for ATP2A1
Gene name ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Gene symbol ATP2A1
Other names/aliases ATP2A
SERCA1
Species Homo sapiens
 Database cross references - ATP2A1
ExoCarta ExoCarta_487
Vesiclepedia VP_487
Entrez Gene 487
HGNC 811
MIM 108730
UniProt O14983  
 ATP2A1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ATP2A1
Molecular Function
    protein homodimerization activity GO:0042803 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 ISS
    calcium-transporting ATPase activity GO:0005388 IDA
    calcium ion binding GO:0005509 ISS
Biological Process
    maintenance of mitochondrion location GO:0051659 IMP
    relaxation of skeletal muscle GO:0090076 IDA
    blood coagulation GO:0007596 TAS
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IMP
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IMP
    calcium ion transport GO:0006816 IMP
    positive regulation of endoplasmic reticulum calcium ion concentration GO:0032470 IMP
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IMP
    positive regulation of fast-twitch skeletal muscle fiber contraction GO:0031448 IDA
    calcium ion import GO:0070509 IMP
    response to endoplasmic reticulum stress GO:0034976 IMP
    ion transmembrane transport GO:0034220 TAS
    negative regulation of striated muscle contraction GO:0045988 IMP
    calcium ion transmembrane transport GO:0070588 IEA
    apoptotic mitochondrial changes GO:0008637 IMP
    metabolic process GO:0008152 IEA
    transmembrane transport GO:0055085 TAS
    regulation of striated muscle contraction GO:0006942 IMP
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    H zone GO:0031673 IDA
    calcium channel complex GO:0034704 IC
    membrane GO:0016020 ISS
    I band GO:0031674 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISS
    platelet dense tubular network membrane GO:0031095 TAS
    perinuclear region of cytoplasm GO:0048471 ISS
    integral component of membrane GO:0016021 NAS
    mitochondrion GO:0005739 IMP
    sarcoplasmic reticulum GO:0016529 NAS
    sarcoplasmic reticulum membrane GO:0033017 TAS
 Experiment description of studies that identified ATP2A1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATP2A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 SLN  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ATP2A1 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome
Pre-NOTCH Processing in Golgi TAS Reactome
Reduction of cytosolic Ca++ levels TAS Reactome





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