Gene description for DSC2
Gene name desmocollin 2
Gene symbol DSC2
Other names/aliases ARVD11
CDHF2
DG2
DGII/III
DSC3
Species Homo sapiens
 Database cross references - DSC2
ExoCarta ExoCarta_1824
Entrez Gene 1824
HGNC 3036
MIM 125645
UniProt Q02487  
 DSC2 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for DSC2
Molecular Function
    cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 IC
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IEA
Biological Process
    regulation of heart rate by cardiac conduction GO:0086091 IMP
    cardiac muscle cell-cardiac muscle cell adhesion GO:0086042 IMP
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 IMP
    regulation of ventricular cardiac muscle cell action potential GO:0098911 IMP
    cellular response to starvation GO:0009267 IEA
    cell adhesion GO:0007155 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
Subcellular Localization
    cell-cell adherens junction GO:0005913 IEA
    desmosome GO:0030057 IDA
    integral component of membrane GO:0016021 IEA
    cytoplasmic vesicle GO:0031410 IDA
    intercalated disc GO:0014704 IDA
    plasma membrane GO:0005886 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified DSC2 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DSC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 JUP 3728
Affinity Capture-Western Homo sapiens
2 DSG2 1829
Invitro Homo sapiens
3 PKP3 11187
Two-hybrid Homo sapiens
4 PKP2 5318
Two-hybrid Homo sapiens
5 DSG1 1828
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DSC2 is involved
No pathways found





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