Gene description for MLLT4
Gene name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Gene symbol MLLT4
Other names/aliases AF6
Species Homo sapiens
 Database cross references - MLLT4
ExoCarta ExoCarta_4301
Vesiclepedia VP_4301
Entrez Gene 4301
HGNC 7137
MIM 159559
UniProt P55196  
 MLLT4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 19056867    
 Gene ontology annotations for MLLT4
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IPI
    cadherin binding GO:0045296 HDA
    cell adhesion molecule binding GO:0050839 IBA
    actin filament binding GO:0051015 IDA
Biological Process
    cell adhesion GO:0007155 TAS
    signal transduction GO:0007165 IEA
    cell-cell signaling GO:0007267 TAS
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of cell-cell adhesion GO:0022409 IMP
    negative regulation of cell migration GO:0030336 IMP
    regulation of protein localization GO:0032880 IBA
    cell-cell adhesion mediated by cadherin GO:0044331 ISS
    pore complex assembly GO:0046931 IMP
    establishment of protein localization to plasma membrane GO:0061951 ISS
    bicellular tight junction assembly GO:0070830 IMP
    establishment of endothelial intestinal barrier GO:0090557 IMP
    positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IDA
    adherens junction GO:0005912 IBA
    nuclear speck GO:0016607 IDA
    cell junction GO:0030054 IDA
    cell-cell contact zone GO:0044291 IDA
    pore complex GO:0046930 IMP
    tight junction GO:0070160 IDA
 Experiment description of studies that identified MLLT4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
12
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
13
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
14
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
16
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MLLT4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 ILDR2  
Proximity Label-MS Homo sapiens
3 RIT1 6016
Two-hybrid Homo sapiens
4 F11R 50848
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 FLOT2 2319
Proximity Label-MS Homo sapiens
6 RAP1GAP 5909
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 DLG5 9231
Proximity Label-MS Homo sapiens
8 SENP3 26168
Affinity Capture-MS Homo sapiens
9 FAM171A2 284069
Proximity Label-MS Homo sapiens
10 UTRN 7402
Proximity Label-MS Homo sapiens
11 RASSF8 11228
Proximity Label-MS Homo sapiens
12 SLC1A5 6510
Proximity Label-MS Homo sapiens
13 LGR4 55366
Affinity Capture-MS Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
15 KSR1  
Affinity Capture-MS Homo sapiens
16 ARHGAP39  
Proximity Label-MS Homo sapiens
17 MARCKS 4082
Proximity Label-MS Homo sapiens
18 LLGL1 3996
Proximity Label-MS Homo sapiens
19 PKP2 5318
Proximity Label-MS Homo sapiens
20 EFR3A 23167
Proximity Label-MS Homo sapiens
21 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ARHGAP21 57584
Proximity Label-MS Homo sapiens
23 TMEM184A  
Affinity Capture-MS Homo sapiens
24 FUOM  
Affinity Capture-MS Homo sapiens
25 PTPN13 5783
Proximity Label-MS Homo sapiens
26 ADGRL2 23266
Proximity Label-MS Homo sapiens
27 DTNA  
Proximity Label-MS Homo sapiens
28 HRAS 3265
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
29 C9orf78 51759
Affinity Capture-MS Homo sapiens
30 CDC25B 994
Affinity Capture-MS Homo sapiens
31 SHB 6461
Proximity Label-MS Homo sapiens
32 SRGAP2 23380
Affinity Capture-MS Homo sapiens
33 BASP1 10409
Proximity Label-MS Homo sapiens
34 WDR6 11180
Proximity Label-MS Homo sapiens
35 CBY1  
Affinity Capture-MS Homo sapiens
36 USP6NL 9712
Proximity Label-MS Homo sapiens
37 PLCH1  
Proximity Label-MS Homo sapiens
38 EIF4E2  
Affinity Capture-MS Homo sapiens
39 LZTS1  
Proximity Label-MS Homo sapiens
40 AMOTL1 154810
Proximity Label-MS Homo sapiens
41 LMO2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 VANGL2  
Proximity Label-MS Homo sapiens
43 SDK1 221935
Proximity Label-MS Homo sapiens
44 PPFIBP1 8496
Proximity Label-MS Homo sapiens
45 MARK2 2011
Proximity Label-MS Homo sapiens
46 KIAA1522 57648
Affinity Capture-MS Homo sapiens
47 KIAA1462 57608
Proximity Label-MS Homo sapiens
48 JAG1 182
Two-hybrid Homo sapiens
49 HSPA2 3306
Affinity Capture-MS Homo sapiens
50 ZBTB21  
Affinity Capture-MS Homo sapiens
51 RASAL2 9462
Proximity Label-MS Homo sapiens
52 ZNF638 27332
Affinity Capture-MS Homo sapiens
53 RAB3IP  
Affinity Capture-MS Homo sapiens
54 NR2C2  
Co-fractionation Homo sapiens
55 TTN 7273
Cross-Linking-MS (XL-MS) Homo sapiens
56 YES1 7525
Proximity Label-MS Homo sapiens
57 SDCCAG3  
Proximity Label-MS Homo sapiens
58 DSC2 1824
Proximity Label-MS Homo sapiens
59 TXNL1 9352
Proximity Label-MS Homo sapiens
60 KIAA1671  
Proximity Label-MS Homo sapiens
61 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 OBSL1 23363
Affinity Capture-MS Homo sapiens
63 MTUS2 23281
Affinity Capture-MS Homo sapiens
64 TRIP11 9321
Proximity Label-MS Homo sapiens
65 GCC2 9648
Proximity Label-MS Homo sapiens
66 PEAK1 79834
Proximity Label-MS Homo sapiens
67 ITGA4 3676
Affinity Capture-MS Homo sapiens
68 ATP2B1 490
Proximity Label-MS Homo sapiens
69 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 VCAM1 7412
Affinity Capture-MS Homo sapiens
71 LRFN1  
Affinity Capture-MS Homo sapiens
72 CEP89 84902
Proximity Label-MS Homo sapiens
73 LYN 4067
Proximity Label-MS Homo sapiens
74 SNX27 81609
Affinity Capture-MS Homo sapiens
75 PTPN14 5784
Proximity Label-MS Homo sapiens
76 ROR2 4920
Proximity Label-MS Homo sapiens
77 SCRIB 23513
Proximity Label-MS Homo sapiens
78 CEP131 22994
Proximity Label-MS Homo sapiens
79 SLC12A2 6558
Proximity Label-MS Homo sapiens
80 KIF14 9928
Proximity Label-MS Homo sapiens
81 SORBS1 10580
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
82 NOTCH2 4853
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
83 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 PLEKHA1 59338
Proximity Label-MS Homo sapiens
85 AGAP1  
Affinity Capture-MS Homo sapiens
86 PFN1 5216
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
87 KIAA1217 56243
Proximity Label-MS Homo sapiens
88 SDK2 54549
Proximity Label-MS Homo sapiens
89 PHLDB2 90102
Proximity Label-MS Homo sapiens
90 CPNE2 221184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 OFD1 8481
Proximity Label-MS Homo sapiens
92 CPNE8 144402
Proximity Label-MS Homo sapiens
93 ANKRD34A  
Affinity Capture-MS Homo sapiens
94 USP21  
Affinity Capture-MS Homo sapiens
95 SORBS2  
Reconstituted Complex Homo sapiens
96 PARK2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
97 CCDC88C 440193
Proximity Label-MS Homo sapiens
98 FAM110A  
Affinity Capture-MS Homo sapiens
99 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
100 TESK2  
Affinity Capture-MS Homo sapiens
101 SIRT7  
Affinity Capture-MS Homo sapiens
102 EFR3B  
Proximity Label-MS Homo sapiens
103 RNF146  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
104 RRAS2 22800
Two-hybrid Homo sapiens
105 NRXN1  
Two-hybrid Homo sapiens
106 Mras  
Affinity Capture-Western Mus musculus
107 HIF1AN 55662
Affinity Capture-MS Homo sapiens
108 CEP152  
Proximity Label-MS Homo sapiens
109 PVRL1 5818
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
110 PARD3 56288
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
111 CCDC85C  
Proximity Label-MS Homo sapiens
112 SIPA1L2  
Proximity Label-MS Homo sapiens
113 NTRK1 4914
Affinity Capture-MS Homo sapiens
114 RIN1 9610
Two-hybrid Homo sapiens
115 TCHP  
Proximity Label-MS Homo sapiens
116 RAP1A 5906
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
117 KCNB2  
Proximity Label-MS Homo sapiens
118 CDH1 999
Proximity Label-MS Homo sapiens
119 SSUH2  
Affinity Capture-MS Homo sapiens
120 BICD2 23299
Proximity Label-MS Homo sapiens
121 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 RPA4  
Proximity Label-MS Homo sapiens
123 MLLT6  
Proximity Label-MS Homo sapiens
124 CEP192 55125
Proximity Label-MS Homo sapiens
125 TPGS1  
Proximity Label-MS Homo sapiens
126 FAM110B  
Affinity Capture-MS Homo sapiens
127 PKP4 8502
Proximity Label-MS Homo sapiens
128 APC  
Proximity Label-MS Homo sapiens
129 SLC19A1 6573
Proximity Label-MS Homo sapiens
130 KCTD3  
Affinity Capture-MS Homo sapiens
131 ANKRD26 22852
Proximity Label-MS Homo sapiens
132 CXADR 1525
Proximity Label-MS Homo sapiens
133 MPHOSPH9  
Proximity Label-MS Homo sapiens
134 ID2  
Affinity Capture-MS Homo sapiens
135 RAP2A 5911
Affinity Capture-MS Homo sapiens
136 SLC4A7 9497
Proximity Label-MS Homo sapiens
137 TMF1 7110
Proximity Label-MS Homo sapiens
138 DST 667
Proximity Label-MS Homo sapiens
139 LIMA1 51474
Affinity Capture-MS Homo sapiens
140 MINK1 50488
Proximity Label-MS Homo sapiens
141 HSPA5 3309
Cross-Linking-MS (XL-MS) Homo sapiens
142 ARHGAP32  
Proximity Label-MS Homo sapiens
143 FAM83B  
Proximity Label-MS Homo sapiens
144 FAM129B 64855
Proximity Label-MS Homo sapiens
145 ITGB1 3688
Proximity Label-MS Homo sapiens
146 ADCY9 115
Proximity Label-MS Homo sapiens
147 DCLK1 9201
Affinity Capture-MS Homo sapiens
148 KMT2A  
Affinity Capture-Western Homo sapiens
149 NAA38  
Co-fractionation Homo sapiens
150 INADL 10207
Proximity Label-MS Homo sapiens
151 SHROOM3 57619
Proximity Label-MS Homo sapiens
152 CDCA3 83461
Proximity Label-MS Homo sapiens
153 MRPS11  
Affinity Capture-MS Homo sapiens
154 USP9X 8239
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
155 ERBB2IP 55914
Proximity Label-MS Homo sapiens
156 CTNNB1 1499
Proximity Label-MS Homo sapiens
157 NUMB 8650
Proximity Label-MS Homo sapiens
158 NRXN2  
Two-hybrid Homo sapiens
159 FAM171A1 221061
Proximity Label-MS Homo sapiens
160 ABLIM2  
Affinity Capture-MS Homo sapiens
161 TJP1 7082
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
162 MAP4K4 9448
Proximity Label-MS Homo sapiens
163 YWHAZ 7534
Affinity Capture-MS Homo sapiens
164 USP54 159195
Proximity Label-MS Homo sapiens
165 CYP1A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 SLC7A5 8140
Proximity Label-MS Homo sapiens
167 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
168 TNRC6B  
Proximity Label-MS Homo sapiens
169 FN1 2335
Affinity Capture-MS Homo sapiens
170 SYDE1 85360
Affinity Capture-MS Homo sapiens
171 PLEKHA5 54477
Proximity Label-MS Homo sapiens
172 TNRC6A 27327
Proximity Label-MS Homo sapiens
173 EPHA7 2045
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
174 LZTS2 84445
Proximity Label-MS Homo sapiens
175 TP53BP2  
Proximity Label-MS Homo sapiens
176 ABLIM3 22885
Affinity Capture-MS Homo sapiens
177 KIRREL 55243
Proximity Label-MS Homo sapiens
178 ARHGAP29 9411
Proximity Label-MS Homo sapiens
179 PCDH7 5099
Proximity Label-MS Homo sapiens
180 SMAD2 4087
Two-hybrid Homo sapiens
181 NIN 51199
Proximity Label-MS Homo sapiens
182 SLC3A2 6520
Proximity Label-MS Homo sapiens
183 C1QTNF1 114897
Affinity Capture-MS Homo sapiens
184 GIGYF1  
Affinity Capture-MS Homo sapiens
185 EGFR 1956
Proximity Label-MS Homo sapiens
186 RPL35A 6165
Affinity Capture-MS Homo sapiens
187 SLC6A15 55117
Proximity Label-MS Homo sapiens
188 SORBS3 10174
Affinity Capture-MS Homo sapiens
189 CGN  
Proximity Label-MS Homo sapiens
190 PVRL4  
Two-hybrid Homo sapiens
191 RHOB 388
Proximity Label-MS Homo sapiens
192 FRMD4B 23150
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
193 CTNNA1 1495
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
194 CCDC88A 55704
Proximity Label-MS Homo sapiens
195 KIDINS220 57498
Proximity Label-MS Homo sapiens
196 SPECC1 92521
Proximity Label-MS Homo sapiens
197 EFNB2 1948
Proximity Label-MS Homo sapiens
198 EPHB3 2049
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
199 CEPT1 10390
Affinity Capture-MS Homo sapiens
200 FRMD6 122786
Proximity Label-MS Homo sapiens
201 CCDC8  
Affinity Capture-MS Homo sapiens
202 TBC1D25  
Affinity Capture-MS Homo sapiens
203 GOLGB1 2804
Proximity Label-MS Homo sapiens
204 DLG1 1739
Proximity Label-MS Homo sapiens
205 EPHB6  
Two-hybrid Homo sapiens
206 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 PRICKLE3  
Affinity Capture-MS Homo sapiens
208 MARK3 4140
Proximity Label-MS Homo sapiens
209 DEPDC1B 55789
Proximity Label-MS Homo sapiens
210 CS 1431
Proximity Label-MS Homo sapiens
211 ARRB2 409
Affinity Capture-MS Homo sapiens
212 PVRL2 5819
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
213 GAB1  
Proximity Label-MS Homo sapiens
214 SLC38A2 54407
Proximity Label-MS Homo sapiens
215 ZDHHC5 25921
Proximity Label-MS Homo sapiens
216 FAM53C 51307
Affinity Capture-MS Homo sapiens
217 ROCK1 6093
Proximity Label-MS Homo sapiens
218 GRB2 2885
Affinity Capture-MS Homo sapiens
219 JUP 3728
Proximity Label-MS Homo sapiens
220 HORMAD2  
Affinity Capture-MS Homo sapiens
221 NRXN3 9369
Two-hybrid Homo sapiens
222 SHROOM1 134549
Proximity Label-MS Homo sapiens
223 PRNP 5621
Affinity Capture-MS Homo sapiens
224 DENND1A 57706
Affinity Capture-MS Homo sapiens
225 FAM171B  
Proximity Label-MS Homo sapiens
226 LSR 51599
Proximity Label-MS Homo sapiens
227 HDAC6 10013
Affinity Capture-Western Homo sapiens
228 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
229 EPHB2 2048
Two-hybrid Homo sapiens
230 MEN1 4221
Affinity Capture-Western Homo sapiens
231 SRSF12  
Affinity Capture-MS Homo sapiens
232 SIPA1L3  
Proximity Label-MS Homo sapiens
233 CAPZA2 830
Affinity Capture-MS Homo sapiens
234 EFNB1 1947
Proximity Label-MS Homo sapiens
235 KIF13B 23303
Affinity Capture-MS Homo sapiens
236 LATS2 26524
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
237 DNMBP 23268
Proximity Label-MS Homo sapiens
238 EPB41L5 57669
Proximity Label-MS Homo sapiens
239 CGNL1  
Proximity Label-MS Homo sapiens
240 CDC42BPA 8476
Proximity Label-MS Homo sapiens
241 ATF1  
Cross-Linking-MS (XL-MS) Homo sapiens
242 NCK2 8440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
243 PPP1R9A  
Proximity Label-MS Homo sapiens
244 FGF9  
Affinity Capture-MS Homo sapiens
245 PPP1R13B  
Proximity Label-MS Homo sapiens
246 NRAS 4893
Affinity Capture-Western Homo sapiens
247 PHACTR4 65979
Proximity Label-MS Homo sapiens
248 KIAA0754  
Proximity Label-MS Homo sapiens
249 FRS2 10818
Proximity Label-MS Homo sapiens
250 SLC38A1 81539
Proximity Label-MS Homo sapiens
251 MAGI1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
252 SLC6A8 6535
Proximity Label-MS Homo sapiens
253 YKT6 10652
Proximity Label-MS Homo sapiens
254 PLEKHA7 144100
Proximity Label-MS Homo sapiens
255 TJP2 9414
Proximity Label-MS Homo sapiens
256 EPHA2 1969
Proximity Label-MS Homo sapiens
257 PAK6 56924
Proximity Label-MS Homo sapiens
258 XPR1 9213
Proximity Label-MS Homo sapiens
259 CUL7 9820
Affinity Capture-MS Homo sapiens
260 KRAS 3845
Proximity Label-MS Homo sapiens
261 DSG2 1829
Proximity Label-MS Homo sapiens
262 PSMD1 5707
Proximity Label-MS Homo sapiens
263 VANGL1 81839
Proximity Label-MS Homo sapiens
264 SNAP23 8773
Proximity Label-MS Homo sapiens
265 ZNF382  
Affinity Capture-MS Homo sapiens
266 RPA3 6119
Proximity Label-MS Homo sapiens
267 CAV1 857
Proximity Label-MS Homo sapiens
268 PVRL3 25945
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
269 CDK16 5127
Affinity Capture-MS Homo sapiens
270 CUL4A 8451
Affinity Capture-MS Homo sapiens
271 SSX2IP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
272 CTNND1 1500
Proximity Label-MS Homo sapiens
273 BCR 613
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
274 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
275 PAK4 10298
Proximity Label-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here