Gene description for FAM171A2
Gene name family with sequence similarity 171, member A2
Gene symbol FAM171A2
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM171A2
ExoCarta ExoCarta_284069
Vesiclepedia VP_284069
Entrez Gene 284069
HGNC 30480
UniProt A8MVW0  
 FAM171A2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FAM171A2
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified FAM171A2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FAM171A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Proximity Label-MS Homo sapiens
2 SGCA  
Affinity Capture-MS Homo sapiens
3 GNAZ 2781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 LYN 4067
Proximity Label-MS Homo sapiens
5 RAB35 11021
Proximity Label-MS Homo sapiens
6 GNG2 54331
Affinity Capture-MS Homo sapiens
7 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 IL7R  
Affinity Capture-MS Homo sapiens
9 PSMA3 5684
Two-hybrid Homo sapiens
10 DYNLL2 140735
Affinity Capture-MS Homo sapiens
11 EBAG9 9166
Proximity Label-MS Homo sapiens
12 TGFBR2 7048
Affinity Capture-MS Homo sapiens
13 LAMTOR1 55004
Proximity Label-MS Homo sapiens
14 MARCKS 4082
Proximity Label-MS Homo sapiens
15 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GJA1 2697
Proximity Label-MS Homo sapiens
17 FAM171B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CD53 963
Affinity Capture-MS Homo sapiens
19 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 EPB41L4A 64097
Proximity Label-MS Homo sapiens
21 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ZNF174  
Affinity Capture-MS Homo sapiens
23 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
24 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LCK 3932
Proximity Label-MS Homo sapiens
26 CX3CL1  
Affinity Capture-MS Homo sapiens
27 NRSN1  
Affinity Capture-MS Homo sapiens
28 EFNB1 1947
Affinity Capture-MS Homo sapiens
29 MPL 4352
Affinity Capture-MS Homo sapiens
30 CLEC4A  
Affinity Capture-MS Homo sapiens
31 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CXADR 1525
Proximity Label-MS Homo sapiens
33 DDX58 23586
Affinity Capture-RNA Homo sapiens
34 OCLN 100506658
Proximity Label-MS Homo sapiens
35 OPALIN  
Affinity Capture-MS Homo sapiens
36 SPACA1 81833
Affinity Capture-MS Homo sapiens
37 LILRB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ALG1L  
Affinity Capture-MS Homo sapiens
39 GJB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TIGIT  
Affinity Capture-MS Homo sapiens
41 DNAJC5 80331
Proximity Label-MS Homo sapiens
42 NTRK3 4916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 BTN2A1 11120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 BACE2 25825
Affinity Capture-MS Homo sapiens
46 C3orf52  
Affinity Capture-MS Homo sapiens
47 SLC39A5 283375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 EPHA2 1969
Proximity Label-MS Homo sapiens
49 TMEM74  
Affinity Capture-MS Homo sapiens
50 KRAS 3845
Proximity Label-MS Homo sapiens
51 RHOB 388
Proximity Label-MS Homo sapiens
52 P4HA3 283208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MLLT4 4301
Proximity Label-MS Homo sapiens
54 BTNL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 C11orf52 91894
Proximity Label-MS Homo sapiens
56 PRDX2 7001
Affinity Capture-MS Homo sapiens
57 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CAV1 857
Proximity Label-MS Homo sapiens
59 TNFSF18 8995
Affinity Capture-MS Homo sapiens
60 GNG8  
Affinity Capture-MS Homo sapiens
61 CAMK2B 816
Two-hybrid Homo sapiens
62 FLOT1 10211
Proximity Label-MS Homo sapiens
63 IDO2  
Affinity Capture-MS Homo sapiens
64 STX6 10228
Proximity Label-MS Homo sapiens
65 NSUN5P1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM171A2 is involved
No pathways found





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