Gene description for BACE2
Gene name beta-site APP-cleaving enzyme 2
Gene symbol BACE2
Other names/aliases AEPLC
Species Homo sapiens
 Database cross references - BACE2
ExoCarta ExoCarta_25825
Entrez Gene 25825
HGNC 934
MIM 605668
UniProt Q9Y5Z0  
 BACE2 identified in exosomes derived from the following tissue/cell type
Melanoma cells 22635005    
 Gene ontology annotations for BACE2
Molecular Function
    aspartic-type endopeptidase activity GO:0004190 IDA
    beta-amyloid binding GO:0001540 IBA
Biological Process
    negative regulation of amyloid precursor protein biosynthetic process GO:0042985 IMP
    beta-amyloid metabolic process GO:0050435 IBA
    membrane protein ectodomain proteolysis GO:0006509 IDA
    peptide hormone processing GO:0016486 NAS
    proteolysis GO:0006508 NAS
    protein catabolic process GO:0030163 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    endosome GO:0005768 IEA
    integral component of membrane GO:0016021 NAS
    cell surface GO:0009986 IEA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified BACE2 in exosomes
Experiment ID 200
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22635005    
Organism Homo sapiens
Experiment description Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Authors Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D.
Journal name Nat Med
Publication year 2012
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BACE2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which BACE2 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here