Gene description for CTAGE5
Gene name CTAGE family, member 5
Gene symbol CTAGE5
Other names/aliases MEA6
MGEA
MGEA11
MGEA6
Species Homo sapiens
 Database cross references - CTAGE5
ExoCarta ExoCarta_4253
Vesiclepedia VP_4253
Entrez Gene 4253
HGNC 7057
MIM 602132
UniProt O15320  
 CTAGE5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CTAGE5
Molecular Function
    protein binding GO:0005515 IPI
    enzyme activator activity GO:0008047 TAS
    cargo receptor activity GO:0038024 IMP
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IMP
    protein secretion GO:0009306 IBA
    protein exit from endoplasmic reticulum GO:0032527 IMP
    vesicle cargo loading GO:0035459 IBA
    vesicle cargo loading GO:0035459 IMP
    lipoprotein transport GO:0042953 IMP
    protein localization to endoplasmic reticulum exit site GO:0070973 IMP
    regulation of guanyl-nucleotide exchange factor activity GO:1905097 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    endoplasmic reticulum exit site GO:0070971 IBA
    endoplasmic reticulum exit site GO:0070971 IDA
 Experiment description of studies that identified CTAGE5 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CTAGE5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK2 7379
Affinity Capture-MS Homo sapiens
2 GPRC5B 51704
Affinity Capture-MS Homo sapiens
3 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
4 CTAGE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MAGEB18  
Two-hybrid Homo sapiens
6 SPCS3 60559
Affinity Capture-MS Homo sapiens
7 ANO6 196527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CEP57  
Two-hybrid Homo sapiens
9 GPRC5C 55890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PSMA3 5684
Two-hybrid Homo sapiens
11 CTAGE8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SERPINA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 OCLN 100506658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 COMMD2 51122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GP9 2815
Affinity Capture-MS Homo sapiens
16 SIDT2 51092
Affinity Capture-MS Homo sapiens
17 TRAF4 9618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PCDHB1  
Affinity Capture-MS Homo sapiens
19 SYCE1  
Affinity Capture-MS Homo sapiens
20 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PDIA4 9601
Proximity Label-MS Homo sapiens
23 AES 166
Two-hybrid Homo sapiens
24 COMMD8 54951
Affinity Capture-MS Homo sapiens
25 SEC11A 23478
Affinity Capture-MS Homo sapiens
26 GGH 8836
Affinity Capture-MS Homo sapiens
27 APOB 338
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
28 ALB 213
Affinity Capture-MS Homo sapiens
29 FAM19A4  
Affinity Capture-MS Homo sapiens
30 CTAGE7P  
Affinity Capture-MS Homo sapiens
31 PRG2  
Affinity Capture-MS Homo sapiens
32 EML4 27436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ECEL1  
Affinity Capture-MS Homo sapiens
34 DGCR6  
Two-hybrid Homo sapiens
35 CEP55 55165
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RGPD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 TTC23L  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 SLC39A7 7922
Affinity Capture-MS Homo sapiens
39 QPRT 23475
Affinity Capture-MS Homo sapiens
40 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 LRRC52  
Affinity Capture-MS Homo sapiens
42 MTFR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RGPD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NCR3  
Affinity Capture-MS Homo sapiens
45 GPRC5D  
Affinity Capture-MS Homo sapiens
46 ATF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 EEF1A2 1917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ANO4 121601
Affinity Capture-MS Homo sapiens
50 COL20A1  
Affinity Capture-MS Homo sapiens
51 IDE 3416
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CIAO1 9391
Affinity Capture-MS Homo sapiens
53 CREM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SIRPD  
Affinity Capture-MS Homo sapiens
55 EMILIN1 11117
Two-hybrid Homo sapiens
56 ARSG 22901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SEC62 7095
Proximity Label-MS Homo sapiens
58 HAO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 BACE2 25825
Affinity Capture-MS Homo sapiens
60 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SLC39A5 283375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 BCHE 590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 DNAJB9 4189
Affinity Capture-MS Homo sapiens
65 MIA3 375056
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
66 CCHCR1  
Two-hybrid Homo sapiens
67 PREB 10113
Affinity Capture-MS Homo sapiens
68 SERPINA10 51156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 ABCB10 23456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CREB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 GRB2 2885
Two-hybrid Homo sapiens
72 SERPINA5 5104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 MPRIP 23164
Affinity Capture-MS Homo sapiens
74 RASAL2 9462
Two-hybrid Homo sapiens
75 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SS18L1  
Two-hybrid Homo sapiens
77 SDF2L1 23753
Affinity Capture-MS Homo sapiens
78 COMMD3 23412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 RGPD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 TTYH1  
Affinity Capture-MS Homo sapiens
81 CTAGE6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PAWR 5074
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here