Gene description for SIDT2
Gene name SID1 transmembrane family, member 2
Gene symbol SIDT2
Other names/aliases CGI-40
Species Homo sapiens
 Database cross references - SIDT2
ExoCarta ExoCarta_51092
Vesiclepedia VP_51092
Entrez Gene 51092
HGNC 24272
UniProt Q8NBJ9  
 SIDT2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SIDT2
Molecular Function
    DNA binding GO:0003677 IEA
    double-stranded RNA binding GO:0003725 IBA
    AP-2 adaptor complex binding GO:0035612 ISS
    AP-1 adaptor complex binding GO:0035650 ISS
    nucleic acid transmembrane transporter activity GO:0051032 ISS
    RNA transmembrane transporter activity GO:0051033 IBA
Biological Process
    cell morphogenesis GO:0000902 IEA
    type B pancreatic cell development GO:0003323 IEA
    RNA catabolic process GO:0006401 ISS
    response to glucose GO:0009749 IEA
    glucose homeostasis GO:0042593 IEA
    type B pancreatic cell proliferation GO:0044342 IEA
    RNA transport GO:0050658 IBA
    RNA transport GO:0050658 IDA
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IEA
Subcellular Localization
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified SIDT2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SIDT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCN4A  
Affinity Capture-MS Homo sapiens
2 POMT2  
Affinity Capture-MS Homo sapiens
3 SLC29A1 2030
Affinity Capture-MS Homo sapiens
4 DDHD2 23259
Affinity Capture-MS Homo sapiens
5 KLRC3  
Affinity Capture-MS Homo sapiens
6 ANKLE2 23141
Affinity Capture-MS Homo sapiens
7 ZDHHC5 25921
Affinity Capture-MS Homo sapiens
8 NPLOC4 55666
Affinity Capture-MS Homo sapiens
9 CHRNA4  
Affinity Capture-MS Homo sapiens
10 SLC15A4 121260
Affinity Capture-MS Homo sapiens
11 DHRS7 51635
Affinity Capture-MS Homo sapiens
12 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GJA1 2697
Affinity Capture-MS Homo sapiens
14 ALG12  
Affinity Capture-MS Homo sapiens
15 TUSC3 7991
Affinity Capture-MS Homo sapiens
16 TMEM9B 56674
Affinity Capture-MS Homo sapiens
17 GHDC  
Affinity Capture-MS Homo sapiens
18 KCNJ11  
Affinity Capture-MS Homo sapiens
19 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SMPDL3B 27293
Affinity Capture-MS Homo sapiens
21 SYVN1 84447
Affinity Capture-MS Homo sapiens
22 ATP11C 286410
Affinity Capture-MS Homo sapiens
23 ST7  
Affinity Capture-MS Homo sapiens
24 MARC1  
Affinity Capture-MS Homo sapiens
25 SLC12A2 6558
Affinity Capture-MS Homo sapiens
26 LRP10 26020
Affinity Capture-MS Homo sapiens
27 TMEM179B 374395
Affinity Capture-MS Homo sapiens
28 VANGL2  
Affinity Capture-MS Homo sapiens
29 UXS1 80146
Affinity Capture-MS Homo sapiens
30 GP1BB 2812
Affinity Capture-MS Homo sapiens
31 AP3S2 10239
Affinity Capture-MS Homo sapiens
32 NDUFB8 4714
Affinity Capture-MS Homo sapiens
33 LPPR3  
Affinity Capture-MS Homo sapiens
34 STS 412
Affinity Capture-MS Homo sapiens
35 CUX1 1523
Affinity Capture-MS Homo sapiens
36 LRRC8C 84230
Affinity Capture-MS Homo sapiens
37 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ARMCX3 51566
Affinity Capture-MS Homo sapiens
39 DNAJC16  
Affinity Capture-MS Homo sapiens
40 ABHD14A  
Affinity Capture-MS Homo sapiens
41 NDUFAF1  
Affinity Capture-MS Homo sapiens
42 CCDC115 84317
Affinity Capture-MS Homo sapiens
43 KLRC2  
Affinity Capture-MS Homo sapiens
44 LCLAT1 253558
Affinity Capture-MS Homo sapiens
45 SLC12A7 10723
Affinity Capture-MS Homo sapiens
46 PTH1R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CTAGE5 4253
Affinity Capture-MS Homo sapiens
48 CLDND1 56650
Affinity Capture-MS Homo sapiens
49 ZDHHC9  
Affinity Capture-MS Homo sapiens
50 TMEM63B 55362
Affinity Capture-MS Homo sapiens
51 CAMLG 819
Affinity Capture-MS Homo sapiens
52 PLEKHB1 58473
Affinity Capture-MS Homo sapiens
53 GOLIM4 27333
Affinity Capture-MS Homo sapiens
54 ACTA2 59
Affinity Capture-MS Homo sapiens
55 HTR3C  
Affinity Capture-MS Homo sapiens
56 CNNM1  
Affinity Capture-MS Homo sapiens
57 KLRC4  
Affinity Capture-MS Homo sapiens
58 GABRD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 FUT8 2530
Affinity Capture-MS Homo sapiens
60 FZD8 8325
Affinity Capture-MS Homo sapiens
61 IL1RAP 3556
Affinity Capture-MS Homo sapiens
62 CHRNB2  
Affinity Capture-MS Homo sapiens
63 UBAC2 337867
Affinity Capture-MS Homo sapiens
64 YIF1A 10897
Affinity Capture-MS Homo sapiens
65 SARAF  
Affinity Capture-MS Homo sapiens
66 ST7L  
Affinity Capture-MS Homo sapiens
67 LRRC8E 80131
Affinity Capture-MS Homo sapiens
68 LYPD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PREB 10113
Affinity Capture-MS Homo sapiens
70 TMEM63A 9725
Affinity Capture-MS Homo sapiens
71 ATP2B4 493
Affinity Capture-MS Homo sapiens
72 UPK1A 11045
Affinity Capture-MS Homo sapiens
73 TMEM131  
Affinity Capture-MS Homo sapiens
74 ERMP1 79956
Affinity Capture-MS Homo sapiens
75 SLC12A9 56996
Affinity Capture-MS Homo sapiens
76 ZACN  
Affinity Capture-MS Homo sapiens
77 CHRND  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PNLDC1  
Affinity Capture-MS Homo sapiens
79 CLRN2  
Affinity Capture-MS Homo sapiens
80 LRRC8A 56262
Affinity Capture-MS Homo sapiens
81 SLC4A2 6522
Affinity Capture-MS Homo sapiens
82 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 FAM189B  
Affinity Capture-MS Homo sapiens
84 ANO6 196527
Affinity Capture-MS Homo sapiens
85 EFNA4  
Affinity Capture-MS Homo sapiens
86 SELT 51714
Affinity Capture-MS Homo sapiens
87 RNF181  
Affinity Capture-MS Homo sapiens
88 GABRA3  
Affinity Capture-MS Homo sapiens
89 SMIM5  
Affinity Capture-MS Homo sapiens
90 ADCY9 115
Affinity Capture-MS Homo sapiens
91 CHRNA10  
Affinity Capture-MS Homo sapiens
92 FITM2  
Affinity Capture-MS Homo sapiens
93 OMA1  
Affinity Capture-MS Homo sapiens
94 DCAKD 79877
Affinity Capture-MS Homo sapiens
95 TBXA2R 6915
Affinity Capture-MS Homo sapiens
96 MIA3 375056
Affinity Capture-MS Homo sapiens
97 WLS 79971
Affinity Capture-MS Homo sapiens
98 DNAJC18  
Affinity Capture-MS Homo sapiens
99 CHRNB4  
Affinity Capture-MS Homo sapiens
100 NDUFB3 4709
Affinity Capture-MS Homo sapiens
101 KLRG2 346689
Affinity Capture-MS Homo sapiens
102 KITLG  
Affinity Capture-MS Homo sapiens
103 GPR89A  
Affinity Capture-MS Homo sapiens
104 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
106 TM2D2 83877
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 DSE 29940
Affinity Capture-MS Homo sapiens
108 DHRS3 9249
Affinity Capture-MS Homo sapiens
109 NAT14 57106
Affinity Capture-MS Homo sapiens
110 KIAA0195 9772
Affinity Capture-MS Homo sapiens
111 ALG9 79796
Affinity Capture-MS Homo sapiens
112 SVOPL  
Affinity Capture-MS Homo sapiens
113 AP3S1 1176
Affinity Capture-MS Homo sapiens
114 MANEA 79694
Affinity Capture-MS Homo sapiens
115 VNN2  
Affinity Capture-MS Homo sapiens
116 C1orf43 25912
Affinity Capture-MS Homo sapiens
117 FZD2 2535
Affinity Capture-MS Homo sapiens
118 PIGO  
Affinity Capture-MS Homo sapiens
119 PIGA  
Affinity Capture-MS Homo sapiens
120 TMPRSS12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 TMEM30B 161291
Affinity Capture-MS Homo sapiens
122 FKRP 79147
Affinity Capture-MS Homo sapiens
123 EPHX1 2052
Affinity Capture-MS Homo sapiens
124 UNC93B1 81622
Affinity Capture-MS Homo sapiens
125 BTN2A2  
Affinity Capture-MS Homo sapiens
126 NDUFC2 4718
Affinity Capture-MS Homo sapiens
127 LRRC8D 55144
Affinity Capture-MS Homo sapiens
128 EDA  
Affinity Capture-MS Homo sapiens
129 SPPL2B 56928
Affinity Capture-MS Homo sapiens
130 SLC27A3 11000
Affinity Capture-MS Homo sapiens
131 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 GOLM1 51280
Affinity Capture-MS Homo sapiens
133 RABAC1 10567
Affinity Capture-MS Homo sapiens
134 VANGL1 81839
Affinity Capture-MS Homo sapiens
135 AP3D1 8943
Affinity Capture-MS Homo sapiens
136 PLD6  
Affinity Capture-MS Homo sapiens
137 THEM6  
Affinity Capture-MS Homo sapiens
138 ECSIT 51295
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SIDT2 is involved
No pathways found





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