Gene description for PLEKHB1
Gene name pleckstrin homology domain containing, family B (evectins) member 1
Gene symbol PLEKHB1
Other names/aliases KPL1
PHR1
PHRET1
Species Homo sapiens
 Database cross references - PLEKHB1
ExoCarta ExoCarta_58473
Entrez Gene 58473
HGNC 19079
MIM 607651
UniProt Q9UF11  
 PLEKHB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PLEKHB1
Molecular Function
    signal transducer activity GO:0004871 TAS
    protein homodimerization activity GO:0042803 IEA
    protein C-terminus binding GO:0008022 IEA
    protein binding GO:0005515 IPI
Biological Process
    regulation of cell differentiation GO:0045595 IEA
    phototransduction GO:0007602 NAS
    multicellular organismal development GO:0007275 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    integral component of membrane GO:0016021 IDA
 Experiment description of studies that identified PLEKHB1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PLEKHB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNAS 2778
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHB1 is involved
No pathways found





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