Gene description for PLEKHB1
Gene name pleckstrin homology domain containing, family B (evectins) member 1
Gene symbol PLEKHB1
Other names/aliases KPL1
PHR1
PHRET1
Species Homo sapiens
 Database cross references - PLEKHB1
ExoCarta ExoCarta_58473
Vesiclepedia VP_58473
Entrez Gene 58473
HGNC 19079
MIM 607651
UniProt Q9UF11  
 PLEKHB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PLEKHB1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    phototransduction GO:0007602 NAS
    regulation of cell differentiation GO:0045595 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
 Experiment description of studies that identified PLEKHB1 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PLEKHB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTLA4  
Affinity Capture-MS Homo sapiens
2 A4GALT  
Affinity Capture-MS Homo sapiens
3 ZDHHC17 23390
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 ATXN1 6310
Two-hybrid Homo sapiens
5 RBFOX2 23543
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KCNE3  
Affinity Capture-MS Homo sapiens
7 RAP1GDS1 5910
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 GPR45  
Affinity Capture-MS Homo sapiens
9 OR10H2  
Affinity Capture-MS Homo sapiens
10 OR10H1  
Affinity Capture-MS Homo sapiens
11 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCR8  
Two-hybrid Homo sapiens
13 SIDT2 51092
Affinity Capture-MS Homo sapiens
14 TAS1R2  
Affinity Capture-MS Homo sapiens
15 FFAR1  
Affinity Capture-MS Homo sapiens
16 TMEM136  
Affinity Capture-MS Homo sapiens
17 AVPR1B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHB1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here