Gene description for RBFOX2
Gene name RNA binding protein, fox-1 homolog (C. elegans) 2
Gene symbol RBFOX2
Other names/aliases FOX2
Fox-2
HNRBP2
HRNBP2
RBM9
RTA
dJ106I20.3
fxh
Species Homo sapiens
 Database cross references - RBFOX2
ExoCarta ExoCarta_23543
Vesiclepedia VP_23543
Entrez Gene 23543
HGNC 9906
MIM 612149
UniProt O43251  
 RBFOX2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RBFOX2
Molecular Function
    transcription corepressor activity GO:0003714 IDA
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    DNA-binding transcription factor binding GO:0140297 IDA
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IBA
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISS
    mRNA processing GO:0006397 IEA
    nervous system development GO:0007399 IBA
    RNA splicing GO:0008380 IEA
    RNA metabolic process GO:0016070 TAS
    estrogen receptor signaling pathway GO:0030520 IDA
    regulation of cell population proliferation GO:0042127 TAS
    negative regulation of DNA-templated transcription GO:0045892 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified RBFOX2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RBFOX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBM38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 NET1 10276
Affinity Capture-MS Homo sapiens
4 GTF2A1L  
Two-hybrid Homo sapiens
5 EIF4G3 8672
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RIOK1 83732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RPS28 6234
Two-hybrid Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 QARS 5859
Two-hybrid Homo sapiens
10 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
11 FBXO7 25793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RBM22 55696
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 PLEKHG6  
Affinity Capture-MS Homo sapiens
14 PLEKHB1 58473
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 YTHDF1 54915
Two-hybrid Homo sapiens
16 Igf2bp2 319765
Two-hybrid Mus musculus
17 DYNC1I2 1781
Proximity Label-MS Homo sapiens
18 ANKRD40 91369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RPA2 6118
Affinity Capture-MS Homo sapiens
20 COPRS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 QKI 9444
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 APC  
Affinity Capture-MS Homo sapiens
23 GPATCH8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DAB1 1600
Two-hybrid Homo sapiens
25 PUM2 23369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 RBM12 10137
Two-hybrid Homo sapiens
27 RHOXF2  
Two-hybrid Homo sapiens
28 ATN1  
Two-hybrid Homo sapiens
29 ASXL1  
Affinity Capture-MS Homo sapiens
30 SOX2  
Affinity Capture-MS Homo sapiens
31 MSI1  
Affinity Capture-MS Homo sapiens
32 LSM5 23658
Two-hybrid Homo sapiens
33 FNDC3B 64778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 Pum2  
Two-hybrid Mus musculus
35 NOL8  
Two-hybrid Homo sapiens
36 C9orf78 51759
Affinity Capture-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 PLEKHG4  
Affinity Capture-MS Homo sapiens
39 ESRP2 80004
Affinity Capture-MS Homo sapiens
40 PJA1  
Affinity Capture-MS Homo sapiens
41 Ophn1  
Affinity Capture-MS Mus musculus
42 TNRC6A 27327
Two-hybrid Homo sapiens
43 CHAF1A  
Two-hybrid Homo sapiens
44 HOXA5  
Affinity Capture-MS Homo sapiens
45 HELZ 9931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PRPF38B 55119
Two-hybrid Homo sapiens
47 RNF8  
Two-hybrid Homo sapiens
48 SUPV3L1 6832
Two-hybrid Homo sapiens
49 CALD1 800
Two-hybrid Homo sapiens
50 CPSF7 79869
Two-hybrid Homo sapiens
51 SNRPC 6631
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 KHDRBS1 10657
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 HMGA1 3159
Two-hybrid Homo sapiens
54 KRT31 3881
Two-hybrid Homo sapiens
55 ADARB1 104
Two-hybrid Homo sapiens
56 SF3B3 23450
Two-hybrid Homo sapiens
57 FAM136A 84908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 SFXN2  
Affinity Capture-MS Homo sapiens
59 SRP68 6730
Two-hybrid Homo sapiens
60 Cnbp 12785
Two-hybrid Mus musculus
61 BCS1L 617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 MYCN  
Affinity Capture-MS Homo sapiens
63 RBM42  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 JMJD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 FAM120A 23196
Affinity Capture-MS Homo sapiens
66 ZNF137P  
Two-hybrid Homo sapiens
67 LARP4B 23185
Affinity Capture-MS Homo sapiens
68 CLASP2 23122
Two-hybrid Homo sapiens
69 DMRTB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
70 ATXN2 6311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 UNK  
Affinity Capture-RNA Homo sapiens
72 TOLLIP 54472
Two-hybrid Homo sapiens
73 PCNP 57092
Two-hybrid Homo sapiens
74 MED7  
Two-hybrid Homo sapiens
75 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
76 DDX21 9188
Two-hybrid Homo sapiens
77 DAZAP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RBM23  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 GLIS2  
Two-hybrid Homo sapiens
80 PEG10 23089
Two-hybrid Homo sapiens
81 CLNS1A 1207
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PPIL4  
Two-hybrid Homo sapiens
83 TRMT61A 115708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 RBM17 84991
Two-hybrid Homo sapiens
85 TBC1D32 221322
Proximity Label-MS Homo sapiens
86 CAMK2B 816
Two-hybrid Homo sapiens
87 VCP 7415
Affinity Capture-MS Homo sapiens
88 DDX5 1655
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
89 NTRK1 4914
Affinity Capture-MS Homo sapiens
90 Rbm47  
Two-hybrid Mus musculus
91 U2AF2 11338
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
92 BAG4  
Two-hybrid Homo sapiens
93 Hnrnpf 98758
Affinity Capture-MS Mus musculus
94 ANKHD1 54882
Two-hybrid Homo sapiens
95 Ddx42 72047
Two-hybrid Mus musculus
96 BOLL  
Two-hybrid Homo sapiens
97 Fubp3  
Two-hybrid Mus musculus
98 PHF12  
Affinity Capture-MS Homo sapiens
99 DENND1B  
Two-hybrid Homo sapiens
100 UPF1 5976
Affinity Capture-MS Homo sapiens
101 C1orf131  
Two-hybrid Homo sapiens
102 ST13 6767
Two-hybrid Homo sapiens
103 PCBP2 5094
Two-hybrid Homo sapiens
104 DPH2 1802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ELAVL2 1993
Two-hybrid Homo sapiens
106 ATXN1 6310
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 BRD7  
Two-hybrid Homo sapiens
108 SDHC 6391
Two-hybrid Homo sapiens
109 OGT 8473
Reconstituted Complex Homo sapiens
110 PSMA3 5684
Two-hybrid Homo sapiens
111 SPATS2L 26010
Two-hybrid Homo sapiens
112 SF1 7536
Two-hybrid Homo sapiens
113 Rbm38  
Two-hybrid Mus musculus
114 C19orf52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 RERE 473
Two-hybrid Homo sapiens
116 KIF20A 10112
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
117 RC3H2  
Affinity Capture-MS Homo sapiens
118 UBAP2 55833
Affinity Capture-MS Homo sapiens
119 HIST1H1E 3008
Two-hybrid Homo sapiens
120 PDIA3 2923
Two-hybrid Homo sapiens
121 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 NR3C1 2908
Proximity Label-MS Homo sapiens
123 RPL3 6122
Two-hybrid Homo sapiens
124 RBMS1 5937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 RBFOX1 54715
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
126 HNRNPA1 3178
Proximity Label-MS Homo sapiens
127 NAF1  
Two-hybrid Homo sapiens
128 Pcbp1 23983
Two-hybrid Mus musculus
129 MYO1C 4641
Two-hybrid Homo sapiens
130 ZC3H10  
Two-hybrid Homo sapiens
131 NXF1 10482
Two-hybrid Homo sapiens
132 SF3A1 10291
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
133 PRMT5 10419
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 FARP2 9855
Affinity Capture-MS Homo sapiens
135 PCBP1 5093
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 MRPL4 51073
Two-hybrid Homo sapiens
137 MTG1  
Two-hybrid Homo sapiens
138 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
139 MYC  
Affinity Capture-MS Homo sapiens
140 RPA3 6119
Affinity Capture-MS Homo sapiens
141 RPS13 6207
Two-hybrid Homo sapiens
142 MSI2 124540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
143 MAPK1IP1L 93487
Two-hybrid Homo sapiens
144 PRRC2A 7916
Affinity Capture-MS Homo sapiens
145 C1orf94  
Two-hybrid Homo sapiens
146 HNRNPAB 3182
Two-hybrid Homo sapiens
147 MATR3 9782
Affinity Capture-MS Homo sapiens
148 RPN1 6184
Two-hybrid Homo sapiens
149 Rps14 20044
Two-hybrid Mus musculus
150 BMI1  
Affinity Capture-MS Homo sapiens
151 PARL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 LMNA 4000
Two-hybrid Homo sapiens
153 C9orf72  
Affinity Capture-MS Homo sapiens
154 RBMS2 5939
Affinity Capture-MS Homo sapiens
155 DOCK3  
Affinity Capture-MS Homo sapiens
156 APOBEC3F 200316
Affinity Capture-MS Homo sapiens
157 PA2G4 5036
Two-hybrid Homo sapiens
158 ALG13 79868
Two-hybrid Homo sapiens
159 SURF6  
Two-hybrid Homo sapiens
160 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
161 ESR2  
Reconstituted Complex Homo sapiens
162 SPOP  
Two-hybrid Homo sapiens
163 HNRNPH2 3188
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
164 SMN1 6606
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
165 FBXL6  
Affinity Capture-MS Homo sapiens
166 RPL4 6124
Two-hybrid Homo sapiens
167 Eif4a1 13681
Two-hybrid Mus musculus
168 VAC14 55697
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
169 ATXN1L  
Two-hybrid Homo sapiens
170 SF3B4 10262
Two-hybrid Homo sapiens
171 RPA1 6117
Affinity Capture-MS Homo sapiens
172 SNRPA 6626
Two-hybrid Homo sapiens
173 PTBP1 5725
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
174 SLC25A15  
Affinity Capture-MS Homo sapiens
175 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
176 EIF4ENIF1 56478
Two-hybrid Homo sapiens
177 KHDRBS2  
Two-hybrid Homo sapiens
178 DDX58 23586
Affinity Capture-RNA Homo sapiens
179 PRRC2B  
Two-hybrid Homo sapiens
180 HNRNPK 3190
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
181 YTHDF3  
Two-hybrid Homo sapiens
182 NR2E3  
Two-hybrid Homo sapiens
183 ESR1  
Reconstituted Complex Homo sapiens
184 RBFOX2 23543
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
185 MBNL1 4154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
186 OTUD4  
Affinity Capture-MS Homo sapiens
187 MAGED1 9500
Two-hybrid Homo sapiens
188 ARHGAP36  
Affinity Capture-MS Homo sapiens
189 POLR3D  
Two-hybrid Homo sapiens
190 Dusp14  
Two-hybrid Mus musculus
191 RBPMS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 PUM1 9698
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 HNRNPF 3185
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
194 SNW1 22938
Two-hybrid Homo sapiens
195 PRPF19 27339
Two-hybrid Homo sapiens
196 APH1A 51107
Two-hybrid Homo sapiens
197 GATAD1  
Affinity Capture-MS Homo sapiens
198 GIMAP4 55303
Two-hybrid Homo sapiens
199 DEDD2  
Two-hybrid Homo sapiens
200 PURB 5814
Two-hybrid Homo sapiens
201 VAV3 10451
Affinity Capture-MS Homo sapiens
202 PRMT1 3276
Affinity Capture-MS Homo sapiens
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