Gene description for Cnbp
Gene name cellular nucleic acid binding protein
Gene symbol Cnbp
Other names/aliases AA408710
Cnbp1
Znf9
Species Mus musculus
 Database cross references - Cnbp
ExoCarta ExoCarta_12785
Vesiclepedia VP_12785
Entrez Gene 12785
UniProt P53996  
 Cnbp identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cnbp
Molecular Function
    single-stranded DNA binding GO:0003697 ISO
    single-stranded RNA binding GO:0003727 IBA
    single-stranded RNA binding GO:0003727 ISO
    mRNA binding GO:0003729 IBA
    zinc ion binding GO:0008270 IEA
    translation regulator activity GO:0045182 IBA
    G-quadruplex DNA binding GO:0051880 IEA
    G-quadruplex DNA binding GO:0051880 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    G-quadruplex DNA formation GO:0071919 IEA
    G-quadruplex DNA formation GO:0071919 ISO
    positive regulation of cytoplasmic translation GO:2000767 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Cnbp in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cnbp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNBP 7555
Affinity Capture-MS Homo sapiens
2 Tmem173  
Proximity Label-MS Mus musculus
3 RBFOX2 23543
Two-hybrid Homo sapiens
4 SF1 7536
Two-hybrid Homo sapiens
5 PRMT1 3276
Affinity Capture-MS Homo sapiens
6 Cpsf6  
Two-hybrid Mus musculus
7 RBM6 10180
Two-hybrid Homo sapiens
8 Rps17 20068
Co-fractionation Mus musculus
9 VASP 7408
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Cnbp is involved
No pathways found





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