Gene description for Ddx42
Gene name DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
Gene symbol Ddx42
Other names/aliases 1810047H21Rik
AW319508
AW556242
B430002H05Rik
RHELP
RNAHP
SF3b125
Species Mus musculus
 Database cross references - Ddx42
ExoCarta ExoCarta_72047
Entrez Gene 72047
UniProt Q810A7  
 Ddx42 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ddx42
Molecular Function
    hydrolase activity GO:0016787 IEA
    ATP binding GO:0005524 IEA
    helicase activity GO:0004386 IEA
    RNA binding GO:0003723 IEA
    poly(A) RNA binding GO:0044822 ISO
    ATP-dependent RNA helicase activity GO:0004004 IBA
    nucleotide binding GO:0000166 IEA
    nucleic acid binding GO:0003676 IEA
Biological Process
    RNA secondary structure unwinding GO:0010501 IBA
    protein localization GO:0008104 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Ddx42 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ddx42
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ddx42 is involved
No pathways found





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