Gene description for Sf3b3
Gene name splicing factor 3b, subunit 3
Gene symbol Sf3b3
Other names/aliases 1810061H24Rik
Species Mus musculus
 Database cross references - Sf3b3
ExoCarta ExoCarta_101943
Entrez Gene 101943
UniProt Q921M3  
 Sf3b3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Sf3b3
Molecular Function
    molecular_function GO:0003674 ND
    nucleic acid binding GO:0003676 IEA
    RNA binding GO:0003723 IBA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
    negative regulation of protein catabolic process GO:0042177 ISO
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 ISO
    U12-type spliceosomal complex GO:0005689 ISO
    spliceosomal complex GO:0005681 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Sf3b3 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sf3b3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sf3b3 is involved
mRNA Splicing - Major Pathway IEA Reactome
mRNA Splicing - Minor Pathway IEA Reactome

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