Gene description for Sf3b3
Gene name splicing factor 3b, subunit 3
Gene symbol Sf3b3
Other names/aliases 1810061H24Rik
5730409A01Rik
AA409318
D8Ertd633e
RSE1
SAP130
mKIAA0017
Species Mus musculus
 Database cross references - Sf3b3
ExoCarta ExoCarta_101943
Entrez Gene 101943
UniProt Q921M3  
 Sf3b3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Sf3b3
Molecular Function
    molecular_function GO:0003674 ND
    nucleic acid binding GO:0003676 IEA
    RNA binding GO:0003723 IBA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
    negative regulation of protein catabolic process GO:0042177 ISO
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 ISO
    U12-type spliceosomal complex GO:0005689 ISO
    spliceosomal complex GO:0005681 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Sf3b3 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sf3b3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sf3b3 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway IEA Reactome
mRNA Splicing - Minor Pathway IEA Reactome





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