Gene description for Srrm1
Gene name serine/arginine repetitive matrix 1
Gene symbol Srrm1
Other names/aliases AA407769
POP101
Srm160
Species Mus musculus
 Database cross references - Srrm1
ExoCarta ExoCarta_51796
Vesiclepedia VP_51796
Entrez Gene 51796
UniProt Q52KI8  
 Srrm1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Srrm1
Molecular Function
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 ISO
Biological Process
    RNA splicing, via transesterification reactions GO:0000375 ISO
    mRNA splicing, via spliceosome GO:0000398 ISO
    regulation of mRNA splicing, via spliceosome GO:0048024 IBA
Subcellular Localization
    spliceosomal complex GO:0005681 IBA
    spliceosomal complex GO:0005681 IDA
    nuclear matrix GO:0016363 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    catalytic step 2 spliceosome GO:0071013 ISO
 Experiment description of studies that identified Srrm1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Srrm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Srsf2 20382
Co-fractionation Mus musculus
2 Sf3b1 81898
Co-fractionation Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Foxp3  
Affinity Capture-MS Mus musculus
5 Dnajc8  
Co-fractionation Mus musculus
6 Prpf19 28000
Co-fractionation Mus musculus
7 Snrpd3 67332
Co-fractionation Mus musculus
8 Rps7 20115
Co-fractionation Mus musculus
9 Ddx39b 53817
Co-fractionation Mus musculus
10 Sf3b3 101943
Co-fractionation Mus musculus
11 Srsf1 110809
Co-fractionation Mus musculus
12 Srpk2 20817
Co-fractionation Mus musculus
13 Srrm2  
Co-fractionation Mus musculus
14 Ppie  
Co-fractionation Mus musculus
15 Syncrip 56403
Co-fractionation Mus musculus
16 Sfpq 71514
Co-fractionation Mus musculus
17 Hnrnpk 15387
Co-fractionation Mus musculus
18 Cwc27  
Co-fractionation Mus musculus
19 Srsf3 20383
Co-fractionation Mus musculus
20 Csnk2a2 13000
Co-fractionation Mus musculus
21 Eftud2 20624
Co-fractionation Mus musculus
22 Kcna3  
Affinity Capture-MS Mus musculus
23 Puf60 67959
Co-fractionation Mus musculus
View the network image/svg+xml



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