Gene description for Srpk2
Gene name serine/arginine-rich protein specific kinase 2
Gene symbol Srpk2
Other names/aliases AW226533
AW492537
AW547358
Wbp6
mSRPK2
Species Mus musculus
 Database cross references - Srpk2
ExoCarta ExoCarta_20817
Vesiclepedia VP_20817
Entrez Gene 20817
UniProt O54781  
 Srpk2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Srpk2
Molecular Function
    magnesium ion binding GO:0000287 IDA
    magnesium ion binding GO:0000287 ISO
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 ISO
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP binding GO:0005524 ISO
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    14-3-3 protein binding GO:0071889 IDA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    spliceosomal complex assembly GO:0000245 IBA
    spliceosomal complex assembly GO:0000245 IDA
    spliceosomal complex assembly GO:0000245 ISO
    angiogenesis GO:0001525 IDA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 ISO
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of cell population proliferation GO:0008284 ISO
    RNA splicing GO:0008380 IDA
    RNA splicing GO:0008380 ISO
    positive regulation of gene expression GO:0010628 IDA
    peptidyl-serine phosphorylation GO:0018105 ISO
    cell differentiation GO:0030154 IEA
    nuclear speck organization GO:0035063 IDA
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IDA
    intracellular signal transduction GO:0035556 ISO
    positive regulation of neuron apoptotic process GO:0043525 IDA
    positive regulation of viral genome replication GO:0045070 ISO
    positive regulation of viral genome replication GO:0045070 ISS
    negative regulation of viral genome replication GO:0045071 ISO
    negative regulation of viral genome replication GO:0045071 ISS
    positive regulation of cell cycle GO:0045787 IDA
    regulation of mRNA processing GO:0050684 IBA
    R-loop processing GO:0062176 ISO
    R-loop processing GO:0062176 ISS
Subcellular Localization
    chromatin GO:0000785 ISO
    chromatin GO:0000785 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    nuclear speck GO:0016607 ISO
    nuclear speck GO:0016607 ISS
 Experiment description of studies that identified Srpk2 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Srpk2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zranb2  
Co-fractionation Mus musculus
2 Tpd52  
Co-fractionation Mus musculus
3 Fxr1 14359
Affinity Capture-MS Mus musculus
4 Fmr1  
Affinity Capture-MS Mus musculus
5 Rbm39 170791
Co-fractionation Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Pde4dip  
Affinity Capture-MS Mus musculus
8 Snrpd1 20641
Co-fractionation Mus musculus
9 Tcof1  
Co-fractionation Mus musculus
10 Mapt  
Affinity Capture-Western Mus musculus
11 Atg5  
Affinity Capture-MS Mus musculus
12 Atg16l1  
Affinity Capture-MS Mus musculus
13 Srsf2 20382
Co-fractionation Mus musculus
14 Rtf1  
Co-fractionation Mus musculus
15 Srrm1 51796
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Srpk2 is involved
No pathways found





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