Gene description for Fxr1
Gene name fragile X mental retardation gene 1, autosomal homolog
Gene symbol Fxr1
Other names/aliases 1110050J02Rik
9530073J07Rik
AI851072
Fxr1h
Fxr1p
Species Mus musculus
 Database cross references - Fxr1
ExoCarta ExoCarta_14359
Vesiclepedia VP_14359
Entrez Gene 14359
UniProt Q61584  
 Fxr1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fxr1
Molecular Function
    RNA binding GO:0003723 ISO
    mRNA binding GO:0003729 IDA
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 ISO
    protein binding GO:0005515 IPI
    RNA strand annealing activity GO:0033592 ISO
    RNA strand annealing activity GO:0033592 ISS
    mRNA 3'-UTR AU-rich region binding GO:0035925 IDA
    mRNA 3'-UTR AU-rich region binding GO:0035925 ISO
    mRNA 3'-UTR AU-rich region binding GO:0035925 ISS
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    ribonucleoprotein complex binding GO:0043021 IDA
    translation regulator activity GO:0045182 IBA
    protein heterodimerization activity GO:0046982 ISO
    protein heterodimerization activity GO:0046982 ISS
    molecular condensate scaffold activity GO:0140693 IDA
Biological Process
    spermatid development GO:0007286 IDA
    muscle organ development GO:0007517 IDA
    muscle organ development GO:0007517 IMP
    muscle organ development GO:0007517 IMP
    muscle organ development GO:0007517 ISO
    muscle organ development GO:0007517 ISS
    post-transcriptional regulation of gene expression GO:0010608 IDA
    post-transcriptional regulation of gene expression GO:0010608 IMP
    negative regulation of translation GO:0017148 IDA
    dentate gyrus development GO:0021542 IMP
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    regulation of mRNA stability GO:0043488 IBA
    regulation of circadian sleep/wake cycle, sleep GO:0045187 IMP
    positive regulation of translation GO:0045727 IBA
    positive regulation of translation GO:0045727 IDA
    positive regulation of translation GO:0045727 ISO
    positive regulation of long-term neuronal synaptic plasticity GO:0048170 IBA
    animal organ development GO:0048513 IBA
    negative regulation of inflammatory response GO:0050728 ISO
    negative regulation of inflammatory response GO:0050728 ISS
    regulation of neurogenesis GO:0050767 IDA
    mRNA transport GO:0051028 IBA
    nuclear pore complex assembly GO:0051292 ISO
    nuclear pore complex assembly GO:0051292 ISS
    nuclear pore localization GO:0051664 ISO
    nuclear pore localization GO:0051664 ISS
    regulation of synaptic transmission, glutamatergic GO:0051966 IMP
    skeletal muscle organ development GO:0060538 IDA
    skeletal muscle organ development GO:0060538 ISO
    mRNA destabilization GO:0061157 ISO
    mRNA destabilization GO:0061157 ISS
    regulation of translation at presynapse, modulating synaptic transmission GO:0099577 IBA
    membraneless organelle assembly GO:0140694 IDA
    negative regulation of long-term synaptic potentiation GO:1900272 IMP
    negative regulation of mRNA catabolic process GO:1902373 IEA
    negative regulation of mRNA catabolic process GO:1902373 ISO
    positive regulation of miRNA-mediated gene silencing GO:2000637 ISO
    positive regulation of miRNA-mediated gene silencing GO:2000637 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nuclear envelope GO:0005635 ISO
    nuclear envelope GO:0005635 ISS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    ribosome GO:0005840 IDA
    cytoplasmic stress granule GO:0010494 IBA
    cytoplasmic stress granule GO:0010494 IEA
    cytoplasmic stress granule GO:0010494 ISO
    axon GO:0030424 IDA
    dendrite GO:0030425 IDA
    ribonucleoprotein granule GO:0035770 IDA
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
    cytoplasmic ribonucleoprotein granule GO:0036464 ISS
    neuron projection GO:0043005 IBA
    costamere GO:0043034 IDA
    dendritic spine GO:0043197 IDA
    intracellular membraneless organelle GO:0043232 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    postsynapse GO:0098794 IDA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Fxr1 in exosomes
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fxr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tdrd3  
Affinity Capture-MS Mus musculus
Co-fractionation Mus musculus
2 Sec16a  
Affinity Capture-MS Mus musculus
3 Edc4  
Affinity Capture-MS Mus musculus
4 Usp9x 22284
Affinity Capture-MS Mus musculus
5 Rcor2  
Affinity Capture-MS Mus musculus
6 Ttc3  
Affinity Capture-MS Mus musculus
7 Ebf3  
Affinity Capture-MS Mus musculus
8 Ap2b1 71770
Affinity Capture-MS Mus musculus
9 Smarca4  
Affinity Capture-MS Mus musculus
10 Dnajc9  
Affinity Capture-MS Mus musculus
11 Fmr1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
12 Farsb 23874
Affinity Capture-MS Mus musculus
13 Hnrnpu 51810
Affinity Capture-MS Mus musculus
14 Soga1  
Affinity Capture-MS Mus musculus
15 Pura 19290
Affinity Capture-MS Mus musculus
16 Thrap3 230753
Affinity Capture-MS Mus musculus
17 Rps6 20104
Co-fractionation Mus musculus
18 Eps15l1  
Affinity Capture-MS Mus musculus
19 Elavl2  
Affinity Capture-MS Mus musculus
20 Ctnna1 12385
Affinity Capture-MS Mus musculus
21 Top3b  
Affinity Capture-MS Mus musculus
22 Caprin1 53872
Affinity Capture-MS Mus musculus
23 Spats2  
Affinity Capture-MS Mus musculus
24 Exog  
Affinity Capture-MS Mus musculus
25 Cenpf  
Affinity Capture-MS Mus musculus
26 Cnot1  
Affinity Capture-MS Mus musculus
27 Akap9  
Affinity Capture-MS Mus musculus
28 Ncor2  
Affinity Capture-MS Mus musculus
29 Ubap2  
Affinity Capture-MS Mus musculus
30 Elavl1 15568
Affinity Capture-MS Mus musculus
31 Ina  
Affinity Capture-MS Mus musculus
32 Snw1  
Affinity Capture-MS Mus musculus
33 Trp53bp1  
Affinity Capture-MS Mus musculus
34 Cep170  
Affinity Capture-MS Mus musculus
35 Ccar1  
Affinity Capture-MS Mus musculus
36 Hnrnpk 15387
Affinity Capture-MS Mus musculus
37 Lmtk3  
Affinity Capture-MS Mus musculus
38 Nacc1  
Affinity Capture-MS Mus musculus
39 Myef2 17876
Affinity Capture-MS Mus musculus
40 Atg16l1  
Affinity Capture-MS Mus musculus
41 Gprasp1  
Affinity Capture-MS Mus musculus
42 Gsk3b  
Affinity Capture-MS Mus musculus
43 Git2  
Affinity Capture-MS Mus musculus
44 Kif2a 16563
Affinity Capture-MS Mus musculus
45 Nup153  
Affinity Capture-MS Mus musculus
46 Farsa  
Affinity Capture-MS Mus musculus
47 Tnik  
Affinity Capture-MS Mus musculus
48 Pde4dip  
Affinity Capture-MS Mus musculus
49 Ankfy1 11736
Affinity Capture-MS Mus musculus
50 Tcof1  
Affinity Capture-MS Mus musculus
51 Ncor1  
Affinity Capture-MS Mus musculus
52 Ctnnb1 12387
Affinity Capture-MS Mus musculus
53 Ilf2 67781
Affinity Capture-MS Mus musculus
54 Vim 22352
Affinity Capture-MS Mus musculus
55 Nefm 18040
Affinity Capture-MS Mus musculus
56 Mdk  
Affinity Capture-MS Mus musculus
57 Zfp219  
Affinity Capture-MS Mus musculus
58 Sec24c  
Affinity Capture-MS Mus musculus
59 Rangap1  
Affinity Capture-MS Mus musculus
60 Ctcf 13018
Affinity Capture-MS Mus musculus
61 Pabpc1 18458
Affinity Capture-MS Mus musculus
62 Itsn1 16443
Affinity Capture-MS Mus musculus
63 Epb4.1l3 13823
Affinity Capture-MS Mus musculus
64 Ccar2  
Affinity Capture-MS Mus musculus
65 Gtpbp4  
Affinity Capture-MS Mus musculus
66 Rdx 19684
Affinity Capture-MS Mus musculus
67 Nanog  
Affinity Capture-MS Mus musculus
68 Golga3  
Affinity Capture-MS Mus musculus
69 Hnrnpm 76936
Affinity Capture-MS Mus musculus
70 Arhgef2  
Affinity Capture-MS Mus musculus
71 Cdh2 12558
Affinity Capture-MS Mus musculus
72 Traf3  
Proximity Label-MS Mus musculus
73 Sphkap  
Affinity Capture-MS Mus musculus
74 Pak2 224105
Affinity Capture-MS Mus musculus
75 Nufip2  
Two-hybrid Mus musculus
76 Fyco1  
Affinity Capture-MS Mus musculus
77 Fxr2  
Affinity Capture-MS Mus musculus
78 Mycbp2 105689
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
79 Trim28 21849
Affinity Capture-MS Mus musculus
80 Hnrnpul2 68693
Affinity Capture-MS Mus musculus
81 Atf6b  
Affinity Capture-MS Mus musculus
82 Ubap2l 74383
Affinity Capture-MS Mus musculus
83 Smarcc2  
Affinity Capture-MS Mus musculus
84 Nop2  
Affinity Capture-MS Mus musculus
85 Kpnb1 16211
Affinity Capture-MS Mus musculus
86 Alyref  
Affinity Capture-MS Mus musculus
87 Srsf1 110809
Affinity Capture-MS Mus musculus
88 Pak3  
Affinity Capture-MS Mus musculus
89 Mllt4  
Affinity Capture-MS Mus musculus
90 Ago1 236511
Affinity Capture-MS Mus musculus
91 Kif21a  
Affinity Capture-MS Mus musculus
92 Git1  
Affinity Capture-MS Mus musculus
93 Map4k4 26921
Affinity Capture-MS Mus musculus
94 MKRN1 23608
Affinity Capture-MS Homo sapiens
95 Ston2  
Affinity Capture-MS Mus musculus
96 Clip1  
Affinity Capture-MS Mus musculus
97 Bclaf1  
Affinity Capture-MS Mus musculus
98 Srpk2 20817
Affinity Capture-MS Mus musculus
99 Bub3 12237
Affinity Capture-MS Mus musculus
100 Dmrt2  
Affinity Capture-MS Mus musculus
101 Nefl  
Affinity Capture-MS Mus musculus
102 Ppfia3  
Affinity Capture-MS Mus musculus
103 Eps15 13858
Affinity Capture-MS Mus musculus
104 Prrc2b 227723
Affinity Capture-MS Mus musculus
105 Arhgef7  
Affinity Capture-MS Mus musculus
106 Dynll1 56455
Affinity Capture-MS Mus musculus
107 Bcor  
Affinity Capture-MS Mus musculus
108 Nedd4 17999
Affinity Capture-MS Mus musculus
109 Eed  
Affinity Capture-MS Mus musculus
110 Hspa9 15526
Affinity Capture-MS Mus musculus
111 Gm8730  
Affinity Capture-MS Mus musculus
112 Camk2b 12323
Affinity Capture-MS Mus musculus
113 Golgb1  
Affinity Capture-MS Mus musculus
114 Dock7  
Affinity Capture-MS Mus musculus
115 Ranbp2  
Affinity Capture-MS Mus musculus
116 Fancd2  
Affinity Capture-MS Mus musculus
117 Camk2a  
Affinity Capture-MS Mus musculus
118 Strap 20901
Affinity Capture-MS Mus musculus
119 N4bp2  
Affinity Capture-MS Mus musculus
120 Wdr47  
Affinity Capture-MS Mus musculus
121 Upf1 19704
Affinity Capture-MS Mus musculus
122 Elavl4  
Affinity Capture-MS Mus musculus
123 Akap8  
Affinity Capture-MS Mus musculus
124 Cdc5l 71702
Affinity Capture-MS Mus musculus
125 Strn 268980
Affinity Capture-MS Mus musculus
126 Dlgap1  
Affinity Capture-MS Mus musculus
127 Spata13  
Affinity Capture-MS Mus musculus
128 Tsc1  
Affinity Capture-MS Mus musculus
129 Prrc2a  
Affinity Capture-MS Mus musculus
130 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
131 Kctd13  
Affinity Capture-MS Mus musculus
132 Tnr  
Affinity Capture-MS Mus musculus
133 Shank3  
Affinity Capture-MS Mus musculus
134 Npm1 18148
Affinity Capture-MS Mus musculus
135 Mia3  
Affinity Capture-MS Mus musculus
136 Grik3  
Affinity Capture-MS Mus musculus
137 Baiap2 108100
Affinity Capture-MS Mus musculus
138 Cep170b  
Affinity Capture-MS Mus musculus
139 Fam120a  
Affinity Capture-MS Mus musculus
140 Herc2  
Affinity Capture-MS Mus musculus
141 Aak1 269774
Affinity Capture-MS Mus musculus
142 Fzr1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
143 Nat10  
Affinity Capture-MS Mus musculus
144 Sbf1  
Affinity Capture-MS Mus musculus
145 Rpl12 269261
Affinity Capture-MS Mus musculus
146 Senp1  
Affinity Capture-MS Mus musculus
147 Ap2a2 11772
Affinity Capture-MS Mus musculus
148 Nop56 67134
Affinity Capture-MS Mus musculus
149 Ap2a1 11771
Affinity Capture-MS Mus musculus
150 Ago2 239528
Affinity Capture-MS Mus musculus
151 Zbtb7b  
Affinity Capture-MS Mus musculus
152 Ccdc88a  
Affinity Capture-MS Mus musculus
153 Scrib 105782
Affinity Capture-MS Mus musculus
154 Ilf3 16201
Affinity Capture-MS Mus musculus
155 Cad 69719
Affinity Capture-MS Mus musculus
156 Prrc2c 226562
Affinity Capture-MS Mus musculus
157 Ppm1h  
Affinity Capture-MS Mus musculus
158 Pcm1  
Affinity Capture-MS Mus musculus
159 Keap1  
Affinity Capture-MS Mus musculus
160 Dnaja1 15502
Affinity Capture-MS Mus musculus
161 Dido1  
Affinity Capture-MS Mus musculus
162 Tbk1  
Affinity Capture-MS Mus musculus
163 Pak1  
Affinity Capture-MS Mus musculus
164 FXR2 9513
Two-hybrid Homo sapiens
165 Zbtb21  
Affinity Capture-MS Mus musculus
166 Kif7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Fxr1 is involved
No pathways found





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