Gene description for Fxr1
Gene name fragile X mental retardation gene 1, autosomal homolog
Gene symbol Fxr1
Other names/aliases 1110050J02Rik
9530073J07Rik
AI851072
Fxr1h
Fxr1p
Species Mus musculus
 Database cross references - Fxr1
ExoCarta ExoCarta_14359
Vesiclepedia VP_14359
Entrez Gene 14359
UniProt Q61584  
 Fxr1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fxr1
Molecular Function
    mRNA 3'-UTR binding GO:0003730 IDA
    nucleic acid binding GO:0003676 IEA
    protein binding GO:0005515 IPI
    RNA binding GO:0003723 IEA
    poly(A) RNA binding GO:0044822 ISO
    G-quadruplex RNA binding GO:0002151 IDA
Biological Process
    multicellular organismal development GO:0007275 IEA
    cell differentiation GO:0030154 IEA
    muscle organ development GO:0007517 IMP
    negative regulation of translation GO:0017148 IDA
Subcellular Localization
    polysome GO:0005844 IDA
    ribonucleoprotein granule GO:0035770 IDA
    costamere GO:0043034 IDA
    membrane GO:0016020 ISO
    axon GO:0030424 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    cytoplasm GO:0005737 ISO
    dendritic spine GO:0043197 IDA
    nucleus GO:0005634 IDA
    dendrite GO:0030425 IDA
 Experiment description of studies that identified Fxr1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fxr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fxr1 is involved
No pathways found





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