Gene description for Npm1
Gene name	nucleophosmin 1
Gene symbol	Npm1
Other names/aliases	B23 NO38 Npm
Species	Mus musculus
Database cross references - Npm1
ExoCarta	ExoCarta_18148
Entrez Gene	18148
UniProt	Q61937
Npm1 identified in exosomes derived from the following tissue/cell type
Fibroblasts	23260141
Mast cells	17486113
Pancreatic cells	19351151

Gene ontology annotations for Npm1

Molecular Function     protein N-terminus binding GO:0047485 IPI     ribosomal small subunit binding GO:0043024 ISO     protein kinase binding GO:0019901 ISO     protein homodimerization activity GO:0042803 ISO     RNA binding GO:0003723 ISO     protein heterodimerization activity GO:0046982 ISO     protein binding GO:0005515 IPI     NF-kappaB binding GO:0051059 ISO     histone binding GO:0042393 ISO     Tat protein binding GO:0030957 ISO     enzyme binding GO:0019899 ISO     nucleic acid binding GO:0003676 IEA     poly(A) RNA binding GO:0044822 ISO     unfolded protein binding GO:0051082 ISO     ribosomal large subunit binding GO:0043023 ISO     transcription coactivator activity GO:0003713 ISO     rRNA binding GO:0019843 IDA     DNA binding GO:0003677 ISO     phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISO     protein kinase inhibitor activity GO:0004860 ISO Biological Process     negative regulation of cell proliferation GO:0008285 ISO     regulation of endoribonuclease activity GO:0060699 ISO     positive regulation of DNA metabolic process GO:0051054 ISO     regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 IGI     response to stress GO:0006950 ISO     cell growth GO:0016049 IDA     DNA repair GO:0006281 ISO     nucleocytoplasmic transport GO:0006913 ISO     negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 ISO     positive regulation of cellular biosynthetic process GO:0031328 IMP     positive regulation of DNA replication GO:0045740 ISO     ribosomal large subunit export from nucleus GO:0000055 IMP     regulation of endodeoxyribonuclease activity GO:0032071 ISO     cell volume homeostasis GO:0006884 IMP     regulation of centriole replication GO:0046599 ISO     ribosomal small subunit biogenesis GO:0042274 IMP     negative regulation of centrosome duplication GO:0010826 ISO     positive regulation of catalytic activity GO:0043085 ISO     cell aging GO:0007569 ISO     protein oligomerization GO:0051259 ISO     centrosome cycle GO:0007098 ISO     rRNA export from nucleus GO:0006407 IMP     negative regulation of mRNA splicing, via spliceosome GO:0048025 IDA     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of protein kinase activity GO:0045860 IDA     protein localization GO:0008104 ISO     ribosomal large subunit biogenesis GO:0042273 IMP     regulation of centrosome duplication GO:0010824 IMP     positive regulation of centrosome duplication GO:0010825 IGI     protein destabilization GO:0031648 IMP     ribosomal small subunit export from nucleus GO:0000056 IDA     positive regulation of cell proliferation GO:0008284 IMP     protein homooligomerization GO:0051260 ISO     regulation of eIF2 alpha phosphorylation by dsRNA GO:0060735 ISO     nucleosome assembly GO:0006334 ISO     positive regulation of translation GO:0045727 ISO     regulation of cell cycle GO:0051726 IMP     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     regulation of neuron apoptotic process GO:0043523 ISO Subcellular Localization     centrosome GO:0005813 ISO     nucleoplasm GO:0005654 ISO     granular component GO:0001652 IDA     nucleus GO:0005634 ISO     focal adhesion GO:0005925 ISO     cell GO:0005623 IMP     cytosol GO:0005829 IDA     intracellular GO:0005622 IMP     nucleolus GO:0005730 ISO     large ribosomal subunit GO:0015934 IDA     membrane GO:0016020 ISO     cytoskeleton GO:0005856 IEA     small ribosomal subunit GO:0015935 IDA     ribonucleoprotein complex GO:0030529 ISO     cytoplasm GO:0005737 ISO     nuclear speck GO:0016607 IDA     spindle pole centrosome GO:0031616 ISO