Gene description for Hnrnpa1
Gene name heterogeneous nuclear ribonucleoprotein A1
Gene symbol Hnrnpa1
Other names/aliases HDP-1
Hdp
Hnrpa1
hnRNP A1
hnrnp-A1
Species Mus musculus
 Database cross references - Hnrnpa1
ExoCarta ExoCarta_15382
Entrez Gene 15382
UniProt P49312  
 Hnrnpa1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Pancreatic cells 19351151    
 Gene ontology annotations for Hnrnpa1
Molecular Function
    nucleotide binding GO:0000166 IEA
    RNA binding GO:0003723 IEA
    nucleic acid binding GO:0003676 IEA
Biological Process
    mRNA processing GO:0006397 IEA
    transport GO:0006810 IEA
    alternative mRNA splicing, via spliceosome GO:0000380 IDA
    mRNA transport GO:0051028 IEA
    RNA splicing GO:0008380 IDA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    ribonucleoprotein complex GO:0030529 ISO
    cytoplasm GO:0005737 IEA
    spliceosomal complex GO:0005681 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Hnrnpa1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hnrnpa1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hnrnpa1 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA IEA Reactome





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