Gene description for Cbx3
Gene name chromobox 3
Gene symbol Cbx3
Other names/aliases HP1g
M32
Species Mus musculus
 Database cross references - Cbx3
ExoCarta ExoCarta_12417
Entrez Gene 12417
 Cbx3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cbx3
Molecular Function
    protein domain specific binding GO:0019904 ISO
    histone methyltransferase binding GO:1990226 ISO
    enzyme binding GO:0019899 ISO
    transcription regulatory region sequence-specific DNA binding GO:0000976 IDA
    identical protein binding GO:0042802 ISO
    protein binding GO:0005515 IPI
Biological Process
    chromatin modification GO:0016568 IEA
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    rhythmic process GO:0048511 IEA
    negative regulation of transcription, DNA-templated GO:0045892 ISO
Subcellular Localization
    chromosome, centromeric region GO:0000775 ISO
    chromatin GO:0000785 ISO
    nuclear euchromatin GO:0005719 ISO
    nuclear envelope GO:0005635 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nuclear heterochromatin GO:0005720 ISO
    condensed chromosome, centromeric region GO:0000779 IDA
    spindle GO:0005819 ISO
    senescence-associated heterochromatin focus GO:0035985 ISO
    nuclear pericentric heterochromatin GO:0031618 IDA
    chromocenter GO:0010369 IDA
 Experiment description of studies that identified Cbx3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cbx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cbx3 is involved
No pathways found





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