Gene description for Lmna
Gene name lamin A
Gene symbol Lmna
Other names/aliases Dhe
Species Mus musculus
 Database cross references - Lmna
ExoCarta ExoCarta_16905
Entrez Gene 16905
UniProt P48678  
 Lmna identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lmna
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Biological Process
    ventricular cardiac muscle cell development GO:0055015 IMP
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 IMP
    nucleus organization GO:0006997 IMP
    sterol regulatory element binding protein import into nucleus GO:0035105 IMP
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    muscle organ development GO:0007517 ISO
    positive regulation of cell aging GO:0090343 ISO
    regulation of protein localization to nucleus GO:1900180 IMP
    establishment of cell polarity GO:0030010 NAS
    regulation of cell migration GO:0030334 IMP
    nuclear envelope organization GO:0006998 IGI
    protein localization to nucleus GO:0034504 IMP
Subcellular Localization
    nuclear membrane GO:0031965 ISO
    intermediate filament GO:0005882 IEA
    nuclear envelope GO:0005635 ISO
    nuclear matrix GO:0016363 ISO
    intracellular GO:0005622 IMP
    nucleus GO:0005634 ISO
    cell GO:0005623 IMP
    nucleoplasm GO:0005654 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    lamin filament GO:0005638 IDA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Lmna in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lmna
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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