Gene description for Lmnb1
Gene name lamin B1
Gene symbol Lmnb1
Other names/aliases -
Species Mus musculus
 Database cross references - Lmnb1
ExoCarta ExoCarta_16906
Vesiclepedia VP_16906
Entrez Gene 16906
UniProt P14733  
 Lmnb1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lmnb1
Molecular Function
    structural molecule activity GO:0005198 IEA
    JUN kinase binding GO:0008432 NAS
    phospholipase binding GO:0043274 IPI
Biological Process
    positive regulation of JNK cascade GO:0046330 NAS
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle GO:0031662 NAS
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    nuclear matrix GO:0016363 ISO
    nuclear membrane GO:0031965 ISO
    nucleus GO:0005634 IDA
    membrane GO:0016020 ISO
    nucleoplasm GO:0005654 IDA
    nuclear inner membrane GO:0005637 IEA
    lamin filament GO:0005638 IDA
    intermediate filament GO:0005882 IEA
 Experiment description of studies that identified Lmnb1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lmnb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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