Gene description for Mycbp2
Gene name MYC binding protein 2
Gene symbol Mycbp2
Other names/aliases AU023734
Species Mus musculus
 Database cross references - Mycbp2
ExoCarta ExoCarta_105689
Entrez Gene 105689
UniProt Q7TPH6  
 Mycbp2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mycbp2
Molecular Function
    protein-glycine ligase activity, elongating GO:0070737 IEA
    metal ion binding GO:0046872 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    ubiquitin-protein transferase activity GO:0004842 IEA
    protein-glycine ligase activity GO:0070735 IEA
    ligase activity GO:0016874 IEA
    zinc ion binding GO:0008270 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
    protein-glutamic acid ligase activity GO:0070739 IEA
    protein-glycine ligase activity, initiating GO:0070736 IEA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
Biological Process
    regulation of cytoskeleton organization GO:0051493 IMP
    branchiomotor neuron axon guidance GO:0021785 IMP
    regulation of protein localization GO:0032880 IMP
    cell morphogenesis involved in neuron differentiation GO:0048667 IMP
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    central nervous system projection neuron axonogenesis GO:0021952 IMP
    negative regulation of protein catabolic process GO:0042177 IDA
    motor neuron axon guidance GO:0008045 IMP
Subcellular Localization
    axon GO:0030424 IDA
    membrane GO:0016020 ISO
    nucleus GO:0005634 IEA
    microtubule cytoskeleton GO:0015630 IDA
 Experiment description of studies that identified Mycbp2 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Mycbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CPNE2 221184
Two-hybrid Homo sapiens
2 CPNE1 8904
Two-hybrid Homo sapiens
3 CPNE4 131034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Mycbp2 is involved
No pathways found

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