Gene description for Mybbp1a
Gene name MYB binding protein (P160) 1a
Gene symbol Mybbp1a
Other names/aliases AL024407
AU019902
P160
p160MBP
p67MBP
Species Mus musculus
 Database cross references - Mybbp1a
ExoCarta ExoCarta_18432
Vesiclepedia VP_18432
Entrez Gene 18432
UniProt Q7TPV4  
 Mybbp1a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mybbp1a
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 TAS
    sequence-specific DNA binding GO:0043565 IBA
    sequence-specific DNA binding GO:0043565 ISO
    E-box binding GO:0070888 IPI
Biological Process
    chromatin remodeling GO:0006338 NAS
    respiratory electron transport chain GO:0022904 IDA
    circadian regulation of gene expression GO:0032922 IDA
    cellular response to glucose starvation GO:0042149 IEA
    cellular response to glucose starvation GO:0042149 ISO
    ribosome biogenesis GO:0042254 IEA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of transcription by RNA polymerase I GO:0045943 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    positive regulation of transcription by RNA polymerase III GO:0045945 ISO
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 ISO
    regulation of G1 to G0 transition GO:1903450 IEA
    regulation of G1 to G0 transition GO:1903450 ISO
    positive regulation of anoikis GO:2000210 IEA
    positive regulation of anoikis GO:2000210 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISO
    nucleolus GO:0005730 NAS
    cytoplasm GO:0005737 IDA
    NLS-dependent protein nuclear import complex GO:0042564 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    B-WICH complex GO:0110016 ISO
 Experiment description of studies that identified Mybbp1a in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mybbp1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mrto4  
Co-fractionation Mus musculus
2 Ctps 51797
Co-fractionation Mus musculus
3 Mycbp2 105689
Affinity Capture-MS Mus musculus
4 Pknox1  
Affinity Capture-MS Mus musculus
5 Utp11l  
Co-fractionation Mus musculus
6 Diexf  
Co-fractionation Mus musculus
7 Hdac2  
Affinity Capture-Western Mus musculus
8 Abt1  
Co-fractionation Mus musculus
9 Rpp30  
Co-fractionation Mus musculus
10 Polr3b  
Co-fractionation Mus musculus
11 Utp18  
Co-fractionation Mus musculus
12 Ftsj3  
Co-fractionation Mus musculus
13 Nop58 55989
Co-fractionation Mus musculus
14 Kctd13  
Affinity Capture-MS Mus musculus
15 Wdr6  
Co-fractionation Mus musculus
16 Smarca2  
Affinity Capture-MS Mus musculus
17 Tfe3  
Affinity Capture-MS Mus musculus
18 Smarca4  
Affinity Capture-MS Mus musculus
19 Sfxn5  
Co-fractionation Mus musculus
20 Mettl21e  
Affinity Capture-MS Mus musculus
21 Myod1  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
Two-hybrid Mus musculus
22 Fzr1  
Affinity Capture-MS Mus musculus
23 Hdac1 433759
Affinity Capture-Western Mus musculus
24 Zfp746  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
25 Xrn2  
Co-fractionation Mus musculus
26 Ppargc1a  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
27 Dmrt2  
Affinity Capture-MS Mus musculus
28 Nanog  
Affinity Capture-MS Mus musculus
29 Rnf2  
Affinity Capture-MS Mus musculus
30 Aatf  
Co-fractionation Mus musculus
31 Polr1e  
Co-fractionation Mus musculus
32 Eed  
Affinity Capture-MS Mus musculus
33 Nacc1  
Affinity Capture-MS Mus musculus
34 Atg16l1  
Affinity Capture-MS Mus musculus
35 Polr2e  
Co-fractionation Mus musculus
36 Nfe2  
Two-hybrid Mus musculus
37 Fancd2  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
38 Elp3 74195
Co-fractionation Mus musculus
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