Gene description for Elp3
Gene name elongator acetyltransferase complex subunit 3
Gene symbol Elp3
Other names/aliases 2610507P14Rik
KAT9
Species Mus musculus
 Database cross references - Elp3
ExoCarta ExoCarta_74195
Vesiclepedia VP_74195
Entrez Gene 74195
UniProt Q9CZX0  
 Elp3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Elp3
Molecular Function
    tRNA binding GO:0000049 IEA
    phosphorylase kinase regulator activity GO:0008607 ISO
    phosphorylase kinase regulator activity GO:0008607 ISS
    acetyltransferase activity GO:0016407 ISO
    metal ion binding GO:0046872 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
    tRNA uridine(34) acetyltransferase activity GO:0106261 ISS
Biological Process
    neuron migration GO:0001764 IMP
    tRNA wobble uridine modification GO:0002098 ISO
    tRNA wobble uridine modification GO:0002098 ISS
    tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation GO:0002926 IBA
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    regulation of transcription by RNA polymerase II GO:0006357 ISS
    central nervous system development GO:0007417 IMP
    positive regulation of cell migration GO:0030335 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    elongator holoenzyme complex GO:0033588 IBA
    elongator holoenzyme complex GO:0033588 ISO
    elongator holoenzyme complex GO:0033588 ISS
 Experiment description of studies that identified Elp3 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Elp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ctps 51797
Co-fractionation Mus musculus
2 Eif2b4  
Co-fractionation Mus musculus
3 Utp11l  
Co-fractionation Mus musculus
4 Diexf  
Co-fractionation Mus musculus
5 Abt1  
Co-fractionation Mus musculus
6 Rpp30  
Co-fractionation Mus musculus
7 Polr3b  
Co-fractionation Mus musculus
8 Utp18  
Co-fractionation Mus musculus
9 Nvl  
Co-fractionation Mus musculus
10 Ftsj3  
Co-fractionation Mus musculus
11 Kctd13  
Affinity Capture-MS Mus musculus
12 Nufip1  
Co-fractionation Mus musculus
13 SMURF1 57154
Affinity Capture-Luminescence Homo sapiens
14 Uckl1  
Co-fractionation Mus musculus
15 Mybbp1a 18432
Co-fractionation Mus musculus
16 Isg20l2  
Co-fractionation Mus musculus
17 Nop14  
Co-fractionation Mus musculus
18 Rrp1  
Co-fractionation Mus musculus
19 Wdr43  
Co-fractionation Mus musculus
20 Zbtb7b  
Affinity Capture-MS Mus musculus
21 Zcchc7  
Co-fractionation Mus musculus
22 Polr1e  
Co-fractionation Mus musculus
23 Polr2e  
Co-fractionation Mus musculus
24 Aatf  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Elp3 is involved
No pathways found





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