Gene description for Ctps
Gene name cytidine 5'-triphosphate synthase
Gene symbol Ctps
Other names/aliases Ctps1
Species Mus musculus
 Database cross references - Ctps
ExoCarta ExoCarta_51797
Vesiclepedia VP_51797
Entrez Gene 51797
UniProt P70698  
 Ctps identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctps
Molecular Function
    CTP synthase activity GO:0003883 IBA
    CTP synthase activity GO:0003883 ISO
    CTP synthase activity GO:0003883 ISS
    ATP binding GO:0005524 IEA
    identical protein binding GO:0042802 IBA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    CTP biosynthetic process GO:0006241 IBA
    CTP biosynthetic process GO:0006241 ISO
    CTP biosynthetic process GO:0006241 ISS
    pyrimidine nucleobase biosynthetic process GO:0019856 IBA
    T cell proliferation GO:0042098 ISO
    T cell proliferation GO:0042098 ISS
    B cell proliferation GO:0042100 ISO
    B cell proliferation GO:0042100 ISS
    'de novo' CTP biosynthetic process GO:0044210 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IEA
    cytoophidium GO:0097268 IBA
    cytoophidium GO:0097268 IEA
    cytoophidium GO:0097268 ISO
 Experiment description of studies that identified Ctps in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctps
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Polr1a  
Co-fractionation Mus musculus
2 D2Wsu81e  
Co-fractionation Mus musculus
3 Ftsj3  
Co-fractionation Mus musculus
4 Cebpz  
Co-fractionation Mus musculus
5 Nsun2 28114
Co-fractionation Mus musculus
6 Trmt1  
Co-fractionation Mus musculus
7 Noc3l  
Co-fractionation Mus musculus
8 Utp11l  
Co-fractionation Mus musculus
9 Dis3  
Co-fractionation Mus musculus
10 Diexf  
Co-fractionation Mus musculus
11 Pdcd11  
Co-fractionation Mus musculus
12 Rcl1  
Co-fractionation Mus musculus
13 Abt1  
Co-fractionation Mus musculus
14 Rpp30  
Co-fractionation Mus musculus
15 Isg20l2  
Co-fractionation Mus musculus
16 Polr3b  
Co-fractionation Mus musculus
17 Rrp1  
Co-fractionation Mus musculus
18 Pwp2  
Co-fractionation Mus musculus
19 Nvl  
Co-fractionation Mus musculus
20 Dhodh  
Co-fractionation Mus musculus
21 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
22 Foxp3  
Affinity Capture-MS Mus musculus
23 Ddx27  
Co-fractionation Mus musculus
24 Wdr6  
Co-fractionation Mus musculus
25 Gar1  
Co-fractionation Mus musculus
26 Uckl1  
Co-fractionation Mus musculus
27 Rrp12  
Co-fractionation Mus musculus
28 Esf1  
Co-fractionation Mus musculus
29 Chaf1a  
Affinity Capture-MS Mus musculus
30 Riok1  
Co-fractionation Mus musculus
31 Ddx17 67040
Co-fractionation Mus musculus
32 Sfxn5  
Co-fractionation Mus musculus
33 Rbm28  
Co-fractionation Mus musculus
34 Imp3  
Co-fractionation Mus musculus
35 Mybbp1a 18432
Co-fractionation Mus musculus
36 Polr3f  
Co-fractionation Mus musculus
37 Gnl2  
Co-fractionation Mus musculus
38 Dcaf13 223499
Co-fractionation Mus musculus
39 Nop14  
Co-fractionation Mus musculus
40 Pinx1  
Co-fractionation Mus musculus
41 Gnl3  
Co-fractionation Mus musculus
42 Utp14b  
Co-fractionation Mus musculus
43 Ranbp6  
Co-fractionation Mus musculus
44 Utp18  
Co-fractionation Mus musculus
45 Abcf2 27407
Co-fractionation Mus musculus
46 Ndor1  
Co-fractionation Mus musculus
47 Gtpbp4  
Co-fractionation Mus musculus
48 Ttc4  
Co-fractionation Mus musculus
49 Sdad1  
Co-fractionation Mus musculus
50 Wdr43  
Co-fractionation Mus musculus
51 Nop58 55989
Co-fractionation Mus musculus
52 Fancd2  
Affinity Capture-MS Mus musculus
53 Zcchc7  
Co-fractionation Mus musculus
54 Polr1e  
Co-fractionation Mus musculus
55 Eed  
Affinity Capture-MS Mus musculus
56 Mrto4  
Co-fractionation Mus musculus
57 Surf6  
Co-fractionation Mus musculus
58 Hgh1 59053
Co-fractionation Mus musculus
59 Lsg1  
Co-fractionation Mus musculus
60 Abce1 24015
Co-fractionation Mus musculus
61 Nfx1  
Co-fractionation Mus musculus
62 Polr2e  
Co-fractionation Mus musculus
63 Aatf  
Co-fractionation Mus musculus
64 Elp3 74195
Co-fractionation Mus musculus
65 Eif5b 226982
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Ctps is involved
PathwayEvidenceSource
Interconversion of nucleotide di- and triphosphates IEA Reactome
Metabolism IEA Reactome
Metabolism of nucleotides IEA Reactome





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